Validation and domain development in mental health and sleep-wake function

心理健康和睡眠觉醒功能的验证和领域开发

• 批准号: 7780843
• 负责人: Paul A Pilkonis
• 金额: $ 132.74万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-28 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7780843
• 关键词: Address; African American; Age; American; Anger; Anxiety; Area; Attention Concentration; Beck depression inventory; Calibration; Chronic Disease; Chronic Insomnia; Collaborations; Country; Decision Making; Development; Diagnosis; Elderly; Evaluation; Goals; Health Sciences; Health Services Research; Health Status; Impaired cognition; Individual; Information Systems; Internet; Intervention; Life; Louisiana; Measurement; Measures; Medicine; Memory; Mental Health; Minority; Mood Disorders; Obstructive Sleep Apnea; Outcome Measure; Participant; Patient Outcomes Assessments; Patient Self-Report; Patients; Population; Principal Investigator; Psychiatry; Public Health; Race; Recruitment Activity; Reporting; Research; Respondent; Sampling; Self Perception; Simulate; Site; Sleep; Sleep Disorders; Sleep disturbances; Suicide; Surveys; System; Universities; Validation; Work; Wrist; actigraphy; age related; depression; diaries; emotional distress; high risk; instrument; member; novel; programs; prospective; psychologic; public health relevance; simulation; systems research; young adult

DESCRIPTION (provided by applicant): The goal of the Patient-Reported Outcomes Measurement Information System (PROMIS) is to develop an adaptive system for measuring outcomes in chronic diseases. The University of Pittsburgh has served as a PROMIS research site since 2004, focusing on the domains of emotional distress and sleep-wake function. We developed 5 PROMIS item banks (depression, anxiety, anger, sleep disturbance, and wake disturbance) of the 11 currently available. This renewal application will continue and extend our earlier work (a) by validating further the item banks we have developed using new samples, underrepresented groups (African Americans and older adults), and longitudinal analyses and (b) by developing new item banks in a complementary area of mental health-positive psychological functioning. Our specific aims are (1) to validate further the PROMIS item banks for emotional distress by demonstrating the feasibility and value of CAT administration; by examining in a more definitive way differential item functioning (DIF) for race and age; and by establishing the greater sensitivity to change of the PROMIS measures compared to conventional legacy instruments in a high-risk population-geriatric patients with depression; (2) to validate further the PROMIS sleep disturbance and wake disturbance item banks with work on construct validity (comparing known groups with clinically diagnosed sleep disorders versus no sleep disorder); convergent and discriminant validity using other common retrospective, qualitative sleep-wake measures and prospective, quantitative assessments (sleep diaries, wrist actigraphy); and treatment responsiveness and minimal important differences by following patients with sleep disorders from initial evaluation through 6-8 weeks of treatment; (3) to examine longitudinal and reciprocal relationships between emotional distress and sleep-wake function by administering these banks prospectively in 4 waves over the course of 12 months to a sample of participants from the RAND American Life Panel; and (4) to develop new item banks to evaluate positive psychological functioning, an area of mental health in the PROMIS domain framework complementary to our work on emotional distress. In all studies, we propose to investigate the value of the comprehensive PROMIS health status profile (i.e., assessments across all 11 current PROMIS item banks) for identifying novel associations between domains and novel profiles of patients with chronic diseases. Our work will involve collaboration with various research groups within the University of Pittsburgh and across the country (RAND, Duke University, and LSU Health Sciences Center-Shreveport). PUBLIC HEALTH RELEVANCE: Our proposed new studies will enhance the value and public health impact of PROMIS by including new samples of older adults and minority populations; examining the utility of PROMIS measures in applied treatment contexts; evaluating longitudinal relationships between the domains of mental health and sleep- wake function; utilizing CAT to maximize efficiency in real-world settings; and demonstrating the value of the overall health status profile that can be derived from all available PROMIS item banks.

描述（由申请人提供）：患者报告结果测量信息系统（PROMIS）的目标是开发一种用于测量慢性病结果的适应性系统。匹兹堡大学自 2004 年以来一直是 PROMIS 研究中心，重点研究情绪困扰和睡眠觉醒功能领域。在目前可用的 11 个 PROMIS 项目库中，我们开发了 5 个项目库（抑郁、焦虑、愤怒、睡眠障碍和觉醒障碍）。此更新应用程序将继续并扩展我们之前的工作（a）通过进一步验证我们使用新样本、代表性不足的群体（非裔美国人和老年人）和纵向分析开发的项目库，以及（b）通过在心理健康的补充领域——积极的心理功能。我们的具体目标是 (1) 通过展示 CAT 管理的可行性和价值，进一步验证 PROMIS 项目库的情绪困扰；通过以更明确的方式检查种族和年龄的差异项目功能（DIF）；与高危人群——老年抑郁症患者中的传统遗留工具相比，PROMIS 措施对变化具有更高的敏感性； (2) 通过构建有效性工作进一步验证 PROMIS 睡眠障碍和觉醒障碍项目库（比较已知的临床诊断睡眠障碍组与无睡眠障碍组）；使用其他常见的回顾性定性睡眠觉醒测量和前瞻性定量评估（睡眠日记、腕部体动记录仪）的收敛和判别效度；跟踪睡眠障碍患者从初始评估到 6-8 周治疗的治疗反应和最小重要差异； (3) 通过在 12 个月内分 4 波前瞻性地对兰德美国生命小组的参与者样本进行这些银行管理，检查情绪困扰与睡眠觉醒功能之间的纵向和相互关系； (4) 开发新的项目库来评估积极的心理功能，这是 PROMIS 领域框架中心理健康的一个领域，与我们在情绪困扰方面的工作相补充。在所有研究中，我们建议调查全面的 PROMIS 健康状况概况（即对当前所有 11 个 PROMIS 项目库的评估）的价值，以识别慢性病患者领域和新概况之间的新关联。我们的工作将涉及与匹兹堡大学和全国各地的各个研究小组（兰德公司、杜克大学和路易斯安那州立大学什里夫波特健康科学中心）的合作。公共卫生相关性：我们提出的新研究将通过纳入老年人和少数族裔的新样本来增强 PROMIS 的价值和公共卫生影响；检查 PROMIS 措施在应用治疗环境中的效用；评估心理健康和睡眠-觉醒功能领域之间的纵向关系；利用 CAT 最大限度地提高现实环境中的效率；并展示可从所有可用的 PROMIS 项目库得出的整体健康状况概况的价值。