Human Disease and the Interplay Between Genes and the Environment

人类疾病以及基因与环境之间的相互作用

• 批准号: 8307533
• 负责人: TERRENCE J. MONKS
• 金额: $ 17.8万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8307533
• 关键词: Environment; Genes; human disease

The University of Arizona (U of A) proposes the establishment of a Human Genes and the Environment Research (HuGER) Training Program. Development of the HuGER training program has been guided by several important realities. Most relevant to the HuGER TG is recognition of the fact that in the coming decades, a more precise determination of the influence of environmental exposures within a given genetic background on disease processes will be required to significantly improve pur ability to predict, detect, treat and monitor disease progression and disease response. In addition it is increasingly clear that epigenetic status will emerge as a critical process that is modulated by environmental exposures, leading to the adverse or beneficial manifestation of that exposure. The HuGER will build upon three inter-disciplinary pre-, and post-doctoral training programs integral to the creation of a successful multi-disciplinary training program that rains scientists in environmental genomics/genetics. An (i) NIEHS supported inter-disciplinary training Drogram in Toxicogenomics and Toxicology, an (ii) NSF Interdisciplinary Graduate Education and Research Training (IGERT) Program in Evolutionary, Functional, and Computational Genomics, and (iii) a Graduate nterdisciplinary Program (GIDP) in Statistics provide the foundation for the evolution of this multi-disciplinary nitiative. The HuGER curriculum has been created specifically to address the unique requirements of a multi-disciplinary training program, the cornerstone of which includes two new courses, redesigning additional courses, "industrial" research rotations, and an emphasis on the development of competent and effective communicators. This is especially important for the new generation of scientists who will need to communicate effectively across multi-disciplinary boundaries. The training environment at the U of A also Drovides trainees with access to appropriate contemporary computing and state-of-the-art technologies. The Training Program Faculty consist of a core of 17 scientists, from 10 departments, with active research programs in the areas of (i) the environmental and public health sciences and engineering, (ii) population and functional genomics/genetics, and (iii) computational biology and statistics/bioinformatics. Six principal units are participating in the HuGER Training Program: [1] the College of Agriculture and Life Sciences; [2 the College of Engineering; [3] the College of Medicine [4] the College of Pharmacy; [5] the College of Public Health; and [6] the College of Sciences. Five of these Colleges participate in the BIOS Institute which brings together scientists from disparate disciplines to solve complex biological problems. The Associate Director a this HuGER application, Dr. Vicki Chandler, is the Director of BIOS. To ensure the program is known for it multidisciplinary emphasis, it will be administratively housed within BIOS.

亚利桑那大学（a）提议建立人类基因和环境 研究（Huger）培训计划。 Huger培训计划的制定是由 几种重要的现实。与Huger TG最相关的是认识到以下事实 几十年来，更精确地确定了给定遗传中环境暴露的影响 疾病过程的背景将需要显着提高PUR预测，检测，治疗的能力 并监测疾病进展和疾病反应。另外，越来越清楚表观遗传 状态将成为一个关键过程，受环境暴露调节，导致不利 或这种暴露的有益表现。拥抱将建立在三个跨学科的前 博士后培训计划是创建成功的多学科培训计划不可或缺的 环境基因组学/遗传学中的科学家。 （i）NIEHS支持跨学科培训 毒理学和毒理学中的DROGRM，（II）NSF跨学科研究生教育和研究 进化，功能和计算基因组学方面的培训（IGERT）计划，以及（iii）研究生 统计数据中的NTERDOGERIALY计划（GIDP）为该多学科的演变奠定了基础 确定性。 Huger课程是专门为解决一个独特要求而创建的 多学科培训计划，其基石包括两个新课程，重新设计 其他课程，“工业”研究轮换以及强调能力和 有效的沟通者。对于新一代的科学家来说，这尤其重要 在多学科边界之间有效沟通。 A的训练环境也 驾驶学员可以访问适当的当代计算和最先进的技术。这 培训课程教师由来自10个部门的17位科学家组成，并进行了积极研究 （i）环境和公共卫生科学与工程领域的计划，（ii）人口 以及功能基因组学/遗传学，以及（iii）计算生物学和统计/生物信息学。六名校长 单位正在参加Huger培训计划：[1]农业与生命科学学院； [2 工程学院； [3]医学院[4]药学院； [5]公立学院 健康;和[6]科学学院。这些大学中有五所参加了BIOS研究所 从不同学科的科学家共同解决复杂的生物学问题。副主任 这个Huger应用程序Vicki Chandler博士是BIOS的主任。为了确保该程序以此为名 多学科重点，它将在BIOS内行政上容纳。