Human Disease and the Interplay Between Genes and the Environment

人类疾病以及基因与环境之间的相互作用

• 批准号: 7464028
• 负责人: TERRENCE J. MONKS
• 金额: $ 23.67万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7464028
• 关键词: Environment; Genes; human disease

DESCRIPTION (provided by applicant) The University of Arizona (U of A) proposes to establishment of a Human Genes and the Environment Research (HuGER) Training Program. Development of the HuGER training program has been guided by several important realities. Most relevant to the HuGER TG is recognition of the fact that in the coming decades, a more precise determination of the influence of environmental exposures within a given genetic background on disease processes will be required to significantly improve our ability to predict, detect, treat and monitor disease progression and disease response. In addition it is increasingly clear that epigenetic status will emerge as a critical process that is modulated by environmental exposures, leading to the adverse or beneficial manifestation of that exposure. The HuGER will build upon three inter-disciplinary pre-, and post-doctoral training programs integral to the creation of a successful multi-disciplinary training program that trains scientists in environmental genomics/genetics. An (i) NIEHS supported inter-disciplinary training program in Toxicogenomics and Toxicology, an (ii) NSF Interdisciplinary Graduate Education and Research Training (IGERT) Program in Evolutionary, Functional, and Computational Genomics, and (iii) a Graduate Interdisciplinary Program (GIDP) in Statistics provide the foundation for the evolution of this multi-disciplinary initiative. The HuGER curriculum has been created specifically to address the unique requirements of a multi-disciplinary training program, the cornerstone of which includes two new courses, redesigning additional courses, "industrial" research rotations, and an emphasis on the development of competent and effective communicators. This is especially important for the new generation of scientists who will need to communicate effectively across multi-disciplinary boundaries. The training environment at the U of A also provides trainees with access to appropriate contemporary computing and state-of-the-art technologies. The Training Program Faculty consist of a core of 17 scientists, from 10 departments, with active research programs in the areas of (i) the environmental and public health sciences and engineering, (ii) population and functional genomics/genetics, and (iii) computational biology and statistics/bioinformatics. Six principal units are participating in the HuGER Training Program: [1] the College of Agriculture and Life Sciences; [2] the College of Engineering; [3] the College of Medicine [4] the College of Pharmacy; [5] the College of Public Health; and [6] the College of Sciences. Five of these Colleges participate in the BIO5 Institute which brings together scientists from disparate disciplines to solve complex biological problems. The Associate Director of this HuGER application, Dr. Vicki Chandler, is the Director of BIO5. To ensure the program is known for its multidisciplinary emphasis, it will be administratively housed within BIO5.

描述（由申请人提供） 亚利桑那大学（A）的大学提议建立人类基因和环境研究（HUGER）培训计划。 Huger培训计划的制定受到了几种重要现实的指导。与Huger TG相关的最相关的是认识到，在未来几十年中，将需要更精确地确定在给定的遗传过程中环境暴露的影响，以显着提高我们预测，检测，检测，治疗和监测疾病进展和疾病反应的能力。此外，越来越明显的是，表观遗传状况将作为一个关键过程，该过程受环境暴露调节，从而导致该暴露的不利或有益表现。拥抱者将建立在三个跨学科前和博士后培训计划的基础上，这是创建成功的多学科培训计划不可或缺的，该计划培训了科学家在环境基因组/遗传学方面的培训。 （i）NIEHS支持毒理学和毒理学领域的跨学科培训计划，一个（II）NSF NSF跨学科研究生教育和研究培训（IGERT）在进化，功能和计算基因组学方面的研究（IGERT）计划，以及（iii）研究生跨学科计划（GIDP）在统计中为这项多I-Diclifial的基础提供了基础。为了满足多学科培训计划的独特要求，该课程是专门创建的，其基石包括两个新课程，重新设计了其他课程，“工业”研究轮换以及强调合格和有效的沟通者的发展。对于新一代的科学家来说，这尤其重要，他们需要在多学科界限上有效沟通。 A的U的培训环境还为受训人员提供了适当的当代计算和最先进的技术。培训计划的教师由来自10个部门的17位科学家组成，并在（i）环境和公共卫生科学与工程领域的积极研究计划中，（ii）人口以及功能性基因组学/遗传学以及（iii）计算生物学和统计学/统计学/生物信息学。六个主要单位正在参加Huger培训计划：[1]农业与生命科学学院； [2]工程学院； [3]医学院[4]药学院； [5]公共卫生学院；和[6]科学学院。这些大学中有五所参加了Bio5研究所，该研究所将科学家从不同学科汇集在一起​​，以解决复杂的生物学问题。此Huger应用程序的副主任Vicki Chandler博士是Bio5的主任。为了确保该计划以其多学科的重点而闻名，它将在Bio5中行政上容纳。