Data Management and Biostatistics

数据管理和生物统计学

• 批准号: 8380035
• 负责人: Oscar Ramirez
• 金额: $ 22.37万
• 依托单位: CAUCASECO SCIENTIFIC RESEARCH CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8380035
• 关键词: Accounting; Address; American; Archives; Area; Biological; Biometry; Biostatistics Core; Brazil; Charge; Code; Collaborations; Colombia; Communication; Complement; Computer Security; Conduct Clinical Trials; Confidentiality; Country; Data; Data Analyses; Data Quality; Data Security; Data Set; Data Sources; Databases; Demographer; Development; Ecuador; Education Projects; Emerging Technologies; Engineering; Ensure; Environment; Epidemiologist; Epidemiology; Ethics; Europe; Field Workers; Goals; Guatemala; Housing; Human; Human Resources; Institution; Internet; Link; Malaria; Methods; Modeling; Monitor; Panama; Participant; Pattern; Persons; Peru; Policies; Protocols documentation; Quality Control; Reporting; Research; Research Activity; Research Design; Research Personnel; Sample Size; Sampling; Services; Site; Standardization; Supervision; Surveys; System; Systems Analysis; Testing; Training; Training Support; Training and Education; United States National Institutes of Health; Work; base; cost effective; data management; data sharing; database structure; experience; innovative technologies; meetings; member; programs; quality assurance; trend; undergraduate student; web site

Data Management (DM) and Biostatistics Core (Core B) will be developed for this ICEMR to support research activities of all projects, providing a centralized DM and analysis system that will be used by all the Consortium members. The primary goal of Core B activities will be to ensure data security, confidentiality and quality as well as provide stafistical support and facilitate communication among the specific project teams. These services represent a valuable integrative feature ofthis ICEMR program intended to meet the diverse needs of each project. We anticipate that this core will be beneficial and essential to the functioning and Integrafion of the various components of this program. Core B involves interdisciplinary scientific teams with key invesfigators from Guatemala, Panama, Colombia, Peru, the initial participating countries, and collaborators from Ecuador, Brazil, US and Europe. Close collaboration is expected to occur among all participants for the development of this DM system that will include data entry, checking and audit trials, tracking systems, security features, and personnel training. Data quality control will be provided by comparing report formats with data sources, assessing data for invalid or missing values, assuring that the data are in their intended operafionalized format, and assessing for deviance in general data patterns. In addifion this Core will give basis forthe implementation of data sharing policies. A Website will be developed for Core B that will have data upload and download capabilifies. This technological capability will facilitate high-level networking with our partner institutions. Statisfical support will be an integral component of this Core that will have biostatisficians as key members. As the studies planned for this ICEMR are observational, epidemiological support will be a key issue for valid and efficient design of study protocols Those activifies will include advice in study design and planning data analyses trying to minimize selection and information biases, for control of confounding factors, and to estimate sample sizes required for the testing of each hypothesis. Also as hierarchical levels of observation are proposed, database structure will be constructed accordingly. The Core will be directed by Dr Oscar Ramirez (MD/MPhll Epidemiology) with the support of a group of epidemiologists participafing in the specific projects (1-3), statisticians and support staff. Drs, G. Carrasquilla, J. Mateus, R. Montoya, F.De la Hoz (Colombia), Llanos (Peru) and C. Guerra (Ecuador) are all epidemiologists with great experience in study design and DM. In addition Dr. O Gomez (US) will provide biostatistics advice. The close relationship of these DM-Core staff members provides a very academic and collaborative environment.

将为此ICEMR开发数据管理（DM）和生物统计学核心（核心B）以支持 所有项目的研究活动，提供所有财团成员将使用的集中式DM和分析系统。核心B活动的主要目标是确保数据安全，机密性和质量，并提供出色的支持并促进特定项目团队之间的沟通。这些服务代表了该ICEMR计划的宝贵综合功能，旨在满足每个项目的各种需求。我们预计该核心将对该程序的各个组成部分的功能和集成至关重要。核心B涉及跨学科的科学团队，来自危地马拉，巴拿马，哥伦比亚，秘鲁，最初参与国家的主要入侵者以及来自厄瓜多尔，巴西，美国和欧洲的合作者。预计将在所有参与者之间进行密切协作，以开发此DM系统，其中包括数据输入，检查和审核试验，跟踪系统，安全功能和人员培训。数据质量控制将通过将报告格式与数据源进行比较，评估无效或缺失值的数据，确保数据采用其预期的操作失败格式，并评估一般数据模式的偏差。简而言之，此核心将为实施数据共享策略提供基础。将为核心B开发一个网站，该网站将上传数据并下载Capabilifies。这种技术能力将促进与我们的合作伙伴机构的高级网络。该核心将是该核心的组成部分，该核心将成为主要成员。正如该ICEMR计划的研究是观察性的，流行病学支持将是研究协议的有效，有效设计这些激活的关键问题，这些激活将包括研究设计和计划数据分析，试图最大程度地减少选择和信息偏见，控制混杂因素，并估算每个假设所需的样本规模。同样，由于提出了层次结构的观察水平，将相应地构建数据库结构。核心将由奥斯卡·拉米雷斯（Oscar Ramirez）博士（MD/MPHLL流行病学）指导，并在一组流行病学家的支持下，参加了特定项目（1-3），统计学家和支持人员。 Drs，G。Carrasquilla，J。Mateus，R。Montoya，F.De La Hoz（哥伦比亚），Llanos（Peru）（秘鲁）和C. Guerra（厄瓜多尔）都是研究设计和DM方面经验丰富的流行病学家。另外，O Gomez博士（美国）将提供生物统计学建议。这些DM核心工作人员的密切关系提供了一个非常学术和协作的环境。