Personalized Medicine for Colorectal and Breast Cancer

结直肠癌和乳腺癌的个性化医疗

• 批准号: 7687989
• 负责人: KATHRYN A PHILLIPS
• 金额: $ 178.93万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-16 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7687989
• 关键词: Personalized; Medicine; Colorectal; Breast; Cancer

DESCRIPTION (provided by applicant): This Program Project Grant proposal addresses personalized medicine - health care targeting medical interventions to patients based on their individual characteristics, particularly their genetics. Our objective is to use an integrated, interdisciplinary approach to obtain evidence about key aspects of the translation of genomic information for breast and colorectal cancer into clinical practice and health policy. Our Program includes four Projects and two Cores with the Specific Aims to: Aim 1: Determine utilization of genomic risk stratification and targeted treatment by using the examples of gene expression profiling (GEP) and HER2/neu testing for trastuzumab (Herceptin(r)) for breast cancer. Aim 2: Develop an understanding of preferences for genomic testing and interventions using the example of Lynch-syndrome screening. Aim 3: Develop a generalized, flexible model for evaluating the cost-effectiveness of personalized medicine and estimate the cost-effectiveness of GEP, HER2/neu testing for trastuzumab, and Lynch syndrome screening using unique data from our Program Projects. Aim 4: Develop an evidence base for translating research findings into practice and policy by collecting and synthesizing data on the clinical applications and the regulatory, policy, and economic impacts of genetically based colorectal and breast cancer interventions. Aim 5: Provide Projects with resources for: conceptualizing, measuring, and investigating population differences; conducting qualitative and quantitative research; identifying and obtaining data sources; coordinating activities; and disseminating findings. The significance of this proposal lies in our goal to establish evidence-based information that will be useful to patients, clinicians, providers, researchers, and policymakers in assessing how personalized medicine can be most beneficial and efficient. Our results will have implications beyond the specific cancers studied, as the issues related to utilization, access, preferences, economics, value, and policy implications are relevant across cancer sites and interventions.

描述（由申请人提供）：该计划项目拨款提案涉及个性化医疗 - 根据患者的个人特征，特别是遗传特征，针对患者进行医疗干预的医疗保健。我们的目标是使用综合的、跨学科的方法来获取有关将乳腺癌和结直肠癌基因组信息转化为临床实践和卫生政策的关键方面的证据。我们的计划包括四个项目和两个核心，具体目标是： 目标 1：通过使用 曲妥珠单抗 (Herceptin(r)) 的基因表达谱 (GEP) 和 HER2/neu 测试示例 乳腺癌。 目标 2：了解基因组测试和干预措施的偏好 林奇综合症筛查的例子。 目标 3：开发一个通用的、灵活的模型来评估个性化的成本效益 医学并使用我们计划项目的独特数据评估 GEP、曲妥珠单抗 HER2/neu 检测和林奇综合征筛查的成本效益。 目标 4：建立证据基础，将研究成果转化为实践和政策 收集和综合有关临床应用以及监管、政策和经济的数据 基于基因的结直肠癌和乳腺癌干预措施的影响。 目标 5：为项目提供以下资源：概念化、测量和调查人口 差异；进行定性和定量研究；识别和获取数据源； 协调活动；并传播调查结果。 该提案的意义在于我们的目标是建立基于证据的信息，这些信息将有助于患者、临床医生、提供者、研究人员和政策制定者评估个性化医疗如何最有益和最有效。我们的结果将产生超出所研究的特定癌症的影响，因为与利用、获取、偏好、经济、价值和政策影响相关的问题与癌症部位和干预措施相关。