Patterns of Substance Use Among HIV Positive and Negative Aging MSM

HIV 阳性和阴性老年 MSM 的物质使用模式

• 批准号: 7686285
• 负责人: Jessica Griffin Burke
• 金额: $ 15.15万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7686285
• 关键词: Acquired Immunodeficiency Syndrome; Address; Age; Age Factors; Aging; Alcohol or Other Drugs use; Applications Grants; Attention; Characteristics; Cohort Studies; Data; Data Analyses; Development; Drug usage; Economics; Elderly; Exhibits; Funding; Future; Goals; HIV; HIV Seropositivity; Habits; Health; Heterosexuals; Intervention; Interview; Knowledge; Life Cycle Stages; Mediator of activation protein; Methods; Modeling; Outcome; Participant; Pattern; Population; Quality of life; Research; Research Project Grants; Secondary to; Social Problems; Substance abuse problem; Testing; Time; Unsafe Sex; Violence; base; cohort; cost effective; depression; design; experience; falls; innovation; men; men who have sex with men; middle age; prevent; research study; response; social

DESCRIPTION (provided by applicant): The goal of this research is to examine the patterns of substance use over time among an existing cohort of HIV positive and negative men who have sex with men (MSM) participating in the Multicenter AIDS Cohort Study (MACS). An important health issue that has received little research attention is how the patterns of substance use among MSM are carried from early age into later life and whether distinct patterns of substance use are associated with decreased functioning, increased health and social problems as MSM age. While research among heterosexual men has found a fall-off or decrease in drug use with increased age, existing research among MSM has not observed a substantial decline in drug use across the life course. This proposal seeks funding to conduct a mixed method study that includes 1) an innovative approach to secondary quantitative data analysis of existing MACS data and 2) qualitative in-depth interviews with select MACS participants. The analysis will compare trajectories of declining substance use with increasing or consistently high levels of use. These pattern comparisons will allow for the identification of resiliency characteristics associated with decreased substance use and related health and social problems. Results will be used as the basis of a future R21 grant application to develop and evaluate a model intervention to prevent substance abuse and related health and social problems among both HIV positive and negative MSM. Quantitative findings regarding the factors that contributed to decreased substance use over time and qualitative data regarding how the participants manage their substance use over time have direct implications for development of a strengths-based intervention. The analysis will also specifically seek to develop hypotheses from the qualitative and quantitative data that can be tested with other aging populations of substance users. Little is known regarding how substance use patterns change or stay stable as MSM age and the factors influencing patterns of change or stability in substance use across the life course. The results of this research will allow for the identification of resiliency characteristics associated with decreased substance use and related health and social problems and will be used as the basis for a future grant application to develop and evaluate a model intervention to prevent substance abuse and related health and social problems among both older HIV positive and negative MSM.

描述（由申请人提供）：这项研究的目的是检查与男性发生性关系的现有艾滋病毒阳性和负面男性（MSM）参与多中心艾滋病队列研究（MAC）的艾滋病毒阳性男性和负面男性的模式。很少受到研究关注的一个重要健康问题是，MSM中使用物质使用的模式是如何从幼龄传达到以后的生活，以及与MSM年龄相关的功能降低，健康和社会问题的降低，健康和社会问题是否与之相关。虽然异性恋男性的研究发现药物使用率下降或减少随着年龄的增长，但MSM中的现有研究并未观察到整个生命过程中药物使用的大幅下降。该提案寻求资金进行一项混合方法研究，其中包括1）一种创新的方法，用于对现有MAC数据的二级定量数据分析以及2）与精选MAC参与者进行的定性深入访谈。该分析将比较衰落的物质使用的轨迹与增加或持续高的使用水平。这些模式比较将允许识别与降低物质使用以及相关的健康和社会问题相关的弹性特征。结果将用作未来R21赠款应用程序的基础，以开发和评估模型干预措施，以防止艾滋病毒阳性和负MSM中的药物滥用以及相关的健康和社会问题。关于随着时间的流逝，有关参与者如何管理其物质使用的定性数据导致物质使用量减少的因素，对基于优势的干预的发展具有直接影响。该分析还将特别寻求从可以与其他老化的药物使用者进行测试的定性和定量数据中开发假设。关于物质使用模式如何随着MSM年龄的变化以及影响整个生命过程中物质使用的变化或稳定性的因素而保持稳定的情况，知之甚少。这项研究的结果将允许识别与降低物质使用以及相关的健康和社会问题相关的弹性特征，并将用作未来赠款应用的基础，以开发和评估模型干预措施，以防止旧的HIV阳性和负面MSM中的药物滥用以及相关的健康和社会问题。