The impact of IL-4 on the CD8 T cell response to pathogens

IL-4对CD8 T细胞对病原体反应的影响

• 批准号: 8293998
• 负责人: STEPHEN C JAMESON
• 金额: $ 22.8万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8293998
• 关键词: Address; Allergic; Antigens; Automobile Driving; Bacteria; Biological Models; CD4 Positive T Lymphocytes; CD8B1 gene; Cells; Cytokine Signaling; Data; Development; Disease; Health; Human; Immune response; Immunity; Infection; Infection Control; Interferons; Interleukin-13; Interleukin-2; Interleukin-4; Lead; Listeria; Listeria monocytogenes; Maintenance; Malaria; Mediating; Memory; Mus; Parasites; Phenotype; Plasmodium; Play; Production; Proteins; Publishing; Resistance; Resolution; Role; Serum Proteins; Signal Transduction; T cell response; T-Cell Proliferation; T-Lymphocyte; Testing; Vaccines; Virus; Work; base; clinically relevant; cytokine; cytokine therapy; improved; innovation; interest; interleukin-13 receptor; novel; pathogen; prevent; receptor; response

DESCRIPTION (provided by applicant): The cytokine IL-4 is well studied for its role in driving allergic/asthmatic CD4 T cell responses: However its impact on CD8 T cells is much less clear. Building on published and preliminary data, we propose that IL-4 plays a critical and unexpected role in supporting the CD8 T cell response to pathogens. These findings will be investigated further to define the exact role of IL-4 responsiveness in the CD8 T cell response, and additional work will test the novel concept that IL-4 cytokine therapy could be used to enhance CD8 T cell protective immunity against malarial parasites. PUBLIC HEALTH RELEVANCE: Many infections are controlled by "killer" T lymphocytes (CTL), and there is a pressing need to improve vaccines that produce these cells. Here we look at an unexpected and interesting role for a serum protein called IL-4 which, based on our preliminary data, is critical to achieve a strong CTL response against infection. We test the role of IL-4 in the CTL responses against two pathogens (Listeria bacteria and malaria parasites) to establish what IL-4 does in controlling CTL responses (Aim 1) and test how this protein can be used to enhance CTL activity in order to prevent malarial disease.

描述（由申请人提供）：细胞因子IL-4在驱动过敏/哮喘CD4 T细胞反应中的作用进行了充分的研究：但是，其对CD8 T细胞的影响还不清楚。在发布和初步数据的基础上，我们建议IL-4在支持CD8 T细胞对病原体的反应中起着至关重要的意外作用。这些发现将进一步研究，以定义IL-4反应性在CD8 T细胞反应中的确切作用，而其他工作将测试IL-4细胞因子疗法可用于增强CD8 T细胞保护性免疫抗疟疾寄生虫。 公共卫生相关性：许多感染受“杀伤” T淋巴细胞（CTL）的控制，并且有迫切需要改善产生这些细胞的疫苗。在这里，我们研究了称为IL-4的血清蛋白的意外和有趣的作用，该蛋白基于我们的初步数据，对于实现针对感染的强大CTL反应至关重要。我们测试IL-4在CTL反应中对两种病原体（李斯特菌细菌和疟疾寄生虫）的作用，以确定IL-4在控制CTL反应中所做的工作（AIM 1），并测试如何使用该蛋白来增强CTL活性以预防疟疾疾病。