Homeostatic Proliferation and Memory CD8 T Cells

稳态增殖和记忆 CD8 T 细胞

基本信息

批准号：
8822792
负责人：
STEPHEN C JAMESON
金额：
$ 38万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-05-01 至 2016-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8822792
关键词：
Address Affect Affinity Animals Antigens Avidity CD8B1 gene Cell Maintenance Cells Characteristics Data Exposure to Generations Goals Growth Health Homeostasis Immune Immune System Part Immune response Immune system Immunity Immunization Inbred BALB C Mice Infection Infectious Agent Influenza Interferons Interleukin-15 Interleukin-4 Interleukin-7 Knowledge Listeria Maintenance Measures Mediating Memory Modeling Mouse Strains Mus Natural Immunity Pathway interactions Phenotype Play Population Production Property Regulation Reporter Research Resistance Role Staging Systems Development T cell response T memory cell T-Lymphocyte Testing TimeLine Transgenic Mice Vaccinated Vaccination Vaccine Design Work adaptive immunity base cell type cytokine data acquisition immune function immunopathology innovation microbial mouse development novel pathogen research study response

项目摘要

DESCRIPTION (provided by applicant): Memory CD8+ T cells provide essential specific immunity against previously encountered antigens, and formation of such cells is a fundamental goal of vaccination. Our data show that the pre-immune population of CD8 T cells contains cells with memory-like properties, which we call "Homeostatic memory" (HM) cells. In this proposal we will test how this population of T cells contributes to primary immune responses. Building on our previous data, we will conduct two aims. 1) how the HM pool responds to pathogens early during an immune response, and how these cells may affect pathogen growth or immunopathology that can arise during immune responses. We will also extend data suggesting HM cells differ qualitatively from "na¿ve" cells in their response to antigen. 2) This aim extends preliminary data suggesting the cytokine IL-4 plays an unexpected role in controlling CD8 T cell responses. We will assess the function of IL- 4 in controlling memory CD8 T cell maintenance, and build on our preliminary data showing that IL-4 supports the CD8 response to pathogens, by determining the stage at which IL-4 mediates its effects.

描述（由申请人提供）：记忆 CD8+ T 细胞提供针对先前遇到的抗原的基本特异性免疫，并且此类细胞的形成是疫苗接种的基本目标。我们的数据表明，CD8 T 细胞的免疫前群体包含具有记忆-的细胞。类似的特性，我们称之为“稳态记忆”（HM）细胞，在本提案中，我们将根据我们之前的数据测试这些 T 细胞如何促进初级免疫反应，我们将实现两个目标：1） HM 细胞如何发挥作用。水池HM 细胞在免疫反应早期对病原体作出反应，以及这些细胞如何影响免疫反应过程中可能出现的病原体生长或免疫病理学。）这一目标扩展了初步数据，表明细胞因子 IL-4 在控制 CD8 T 细胞反应中发挥着意想不到的作用，我们将评估 IL-4 在控制记忆 CD8 T 细胞维持中的功能，并以我们的初步数据为基础，表明 IL-4。 4 支持CD8响应通过确定 IL-4 介导其作用的阶段来识别病原体。