Western Regional Center of Excellence for Biodefense and Emerging Infectious Dise

西部地区生物防御和新发传染病卓越中心

• 批准号: 7908303
• 负责人: DAVID H WALKER
• 金额: $ 93.23万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-12 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7908303
• 关键词: Western; Regional; Center; Excellence; Biodefense

DESCRIPTION (provided by applicant): The mission of the Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (WRCE) is the creation of synergistic,.multifaceted research, strong infrastructure, and activities to develop vaccines, therapeutics, and diagnostics against natural and manmade emerging infectious disease threats by applying the best basic and translational science. Scientists from 22 institutions propose to conduct 15 major research projects and provide six supportive core activities. The WRCE is a unifying force in Texas, New Mexico, Oklahoma, Arkansas, and Louisiana for collaborative research on infectious diseases. The evaluation of the national RCE program revealed that the WRCE was the top performer in the number of new investigators in biodefense, number of projects, number of organisms studied, number of patents filed, and number of new projects supported by other funds that stemmed from RCE projects. Successful basic scientists with substantial expertise in Category A-C agents have truly embraced the unfamiliar goal of translational product-oriented research. The 15 major projects address four themes: development of therapeutic agents for RNA viruses, platforms for multiplexed diagnostics for Category A-C agents and emerging agents, vaccine development for arboviral and emerging viral diseases, and vaccine development for diseases caused by intracellular bacteria. The 15 projects are currently pursuing new specific aims; this is a result of the WRCE's strategy in the previous grant cycle to support developmental type grants to initiate next-stage projects, and an early competition for major projects one year before the completion of the cycle. This planning process allowed selection of the best, most relevant science and development of synergistic interactions within the themes. Attentive guidance by the administrative core's analysis of progress reports, site visits, regional meetings, workshops, and formal external product development consultations support research activities, along with monthly theme meetings to ensure the continued success of projects. Highly productive scientists utilize such regional sources as three national primate research centers, 19 institutions with BSL-3 laboratories, two institutions with BSL-4 laboratories, two vaccine development centers, two DOE national laboratories, 13 participating medical universities, three participating veterinary schools, and four institutions with aerobiology expertise to translate their outstanding scientific knowledge into program that delivers more than the sum of its parts. RELEVANCE: The Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research scientific program supports the national effort toward developing new drugs, diagnostics, and vaccines for infectious disease agents. The emergency response preparedness plan also ensures that facilities and subject matter expertise will be provided during a bioterror event or naturally occurring outbreak. STRATEGIC MANAGEMENT PLAN DESCRIPTION: The Administrative Core is responsible for the overall management and coordination of the Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (WRCE). It provides governance, financial oversight, and operational management functions to facilitate the execution of the strategic research plan, thereby enabling the WRCE to fulfill its mission to develop new diagnostics, therapeutics and vaccines for Category A, B, and C and emerging infectious disease infectious agents. Specific functions include: (1) the development of policies governing WRCE operations; (2) management of financial resources; (3) coordination of activities of standing advisory committees; (4) oversight of research projects and core facilities; (5) implementation of research programs for major Research Projects, Developmental Research projects, Career Development projects; (6) facilitation of communication and information dissemination among scientists, institutional officials, and external groups; (7) coordination of research enrichment activities; (8) management of the annual strategic planning process; (9) maintenance of records and preparation of reports and annual continuation applications; and (10) development of the regional Emergency Response Plan. The Administrative Core also has an Associate Director of Product Development. This individual helps identify translational research funding opportunities and guides project leaders through regulatory issues as projects advance, and also chairs the WRCE Product Development Working Group. Management activities are carried out with the advice of the Steering Committee, a Policy Advisory Board, an External Advisory Board, a Regional Council, individual research project and core leaders, and other key personnel of the WRCE, all in close collaboration with NIAID's biodefense program administrators. Teleconferencing and videoconferencing are maximally utilized to facilitate communication between the University of Texas Medical Branch, the lead institution for the WRCE, and other institutions in the RCE Biodefense Network. RELEVANCE (See instructions): The WRCE Administrative Core provides overall management and coordination of the programs for the Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research. The scientific program and emergency response preparedness plan support the national effort toward developing new drugs, diagnostics, or vaccines for infectious disease agents.

描述（由申请人提供）：西部地区生物防御和新发传染病研究卓越中心 (WRCE) 的使命是创建协同、多方面的研究、强大的基础设施和活动，以开发针对该疾病的疫苗、治疗方法和诊断方法。通过应用最好的基础科学和转化科学来应对自然和人为新出现的传染病威胁。来自22个机构的科学家提议开展15个重大研究项目并提供六项支持性核心活动。 WRCE 是德克萨斯州、新墨西哥州、俄克拉荷马州、阿肯色州和路易斯安那州的一支团结力量，致力于传染病的合作研究。对国家 RCE 计划的评估显示，WRCE 在生物防御新研究者数量、项目数量、研究生物体数量、申请专利数量以及由其他基金支持的新项目数量方面表现最好。 RCE 项目。在 A-C 类药物方面拥有丰富专业知识的成功基础科学家真正接受了以转化产品为导向的研究这一陌生的目标。这15个主要项目涉及四个主题：RNA病毒治疗剂的开发、A-C类药物和新兴药物的多重诊断平台、虫媒病毒和新出现的病毒性疾病的疫苗开发以及细胞内细菌引起的疾病的疫苗开发。这 15 个项目目前正在追求新的具体目标；这是 WRCE 在上一个赠款周期中制定的战略的结果，该战略旨在支持开发型赠款以启动下一阶段的项目，以及在该周期完成前一年对重大项目进行早期竞争。这一规划过程允许选择最好的、最相关的科学，并在主题内发展协同互动。行政核心对进度报告的分析、实地考察、区域会议、研讨会和正式的外部产品开发咨询的细心指导支持研究活动，以及每月的主题会议，以确保项目的持续成功。高产科学家利用区域资源，如三个国家灵长类动物研究中心、19 个拥有 BSL-3 实验室的机构、两个拥有 BSL-4 实验室的机构、两个疫苗开发中心、两个能源部国家实验室、13 所参与的医科大学、三所参与的兽医学校、以及四家拥有空气生物学专业知识的机构，将其杰出的科学知识转化为项目，其成果超过其各个部分的总和。 相关性：西部地区生物防御和新发传染病研究卓越中心科学计划支持国家为传染病病原体开发新药、诊断方法和疫苗的努力。应急响应准备计划还确保在生物恐怖事件或自然发生的爆发期间提供设施和主题专业知识。 战略管理计划描述： 行政核心负责西部地区生物防御和新发传染病研究卓越中心（WRCE）的整体管理和协调。它提供治理、财务监督和运营管理职能，以促进战略研究计划的执行，从而使 WRCE 能够履行其使命，为 A、B、C 类和新出现的传染病传染病开发新的诊断、治疗方法和疫苗。代理。具体职能包括： (1) 制定WRCE运行政策； （二）财务资源管理； （三）协调常设咨询委员会的活动； （四）研究项目和核心设施的监督； （五）重大科研项目、发展研究项目、职业发展项目等研究项目的实施； (6) 促进科学家、机构官员和外部团体之间的沟通和信息传播； (7) 协调研究丰富活动； （八）年度战略规划过程的管理； (9) 保存记录并准备报告和年度延续申请； (10) 制定区域应急预案。行政核心还设有产品开发副总监。此人帮助确定转化研究资助机会，并在项目进展过程中指导项目负责人解决监管问题，同时还担任 WRCE 产品开发工作组的主席。管理活动是在指导委员会、政策咨询委员会、外部咨询委员会、区域委员会、个别研究项目和核心领导者以及 WRCE 的其他关键人员的建议下进行的，所有这些都与 NIAID 的生物防御计划密切合作管理员。最大限度地利用电话会议和视频会议来促进 WRCE 的牵头机构德克萨斯大学医学分部与 RCE 生物防御网络中的其他机构之间的沟通。相关性（参见说明）：WRCE 行政核心为西部地区生物防御和新发传染病研究卓越中心的项目提供总体管理和协调。科学计划和应急准备计划支持国家为传染病病原体开发新药、诊断方法或疫苗的努力。