SWAN NJ-Quantitative and Qualitative cohort Research

SWAN NJ-定量和定性队列研究

• 批准号: 8300839
• 负责人: CAROL A. DERBY
• 金额: $ 37.71万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8300839
• 关键词: Accounting; Address; Adverse reactions; Alternative Medicine; Androstenedione; Area; Atherosclerosis; Blood; Body Weight; Calories; Clinical; Clinical Research; Cognition; Complementary and alternative medicine; Data; Degenerative polyarthritis; Development; Diabetes Mellitus; Diet; Distress; Energy Intake; Equilibrium; Estrone; Ethnic Origin; Ethnic group; Food; Fracture; Frequencies; Gait; Happiness; Health; Hispanics; Hormonal; Hormones; Instruction; Interview; Life; Major Depressive Disorder; Maps; Measurement; Medical; Menopausal Symptom; Menopause; Metabolic; Metabolic syndrome; N-formylmethionylphenylalanine; New Jersey; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Participant; Pattern; Performance; Physical Function; Population; Prevalence; Principal Investigator; Protein Isoforms; Qualitative Methods; Qualitative Research; Quality of life; Questionnaires; Race; Recruitment Activity; Reporting; Research; Resolution; Rest; Risk Factors; SHBG gene; Severities; Sex Functioning; Site; Sleep; Stress; Surveys; Symptoms; Testing; Time; United States; Vagina; Vasomotor; Weight Gain; Woman; Women' s Health; base; bone; cardiovascular risk factor; cohort; coping; coping mechanism; diabetes risk; ethnic minority population; experience; follow-up; hormone therapy; inflammatory marker; low socioeconomic status; member; middle age; programs; satisfaction

Program Director/Principal Investigator (Last, First, Middle): SantOrO, Nanette PROJECT SUMMARY (See instructions): SWAN, the Study of Women's Health Across the Nation, is a multi-ethnic, multi-site study of mid life women in the United States that has been active for over 10 years. The SWAN-New Jersey cohort had the lowest socio-economic status, the poorest health indicators at baseline and has suffered from substantialloss to follow up and impediments to continued research. Despite substantial attrition, SWAN-New Jersey Hispanic women continue to have the highest rate of incident metabolic syndrome and type 2 diabetes, and report more symptoms with more adverse reactions to their symptoms over the menopause transition compared to the rest of the SWAN cohort. We have also recognized the need to better understand key discrepancies between our data on Hispanic women and the rest of the cohort with respect to the use of complementary and alternativemedicineand the reporting of total daily caloric intake. We thus propose 3 specific aims that will focus exclusively on the remaining Hispanic cohort members (n=150) and seek to integrate quantitative and qualitative methods of inquiriy: Aim 1 will continue to collect quantitative data;physical measurements, blood and abbreviated survey data and SCID interviewson our Hispanic cohort members to address as may overall SWAN FVhypotheses as are feasible and to test specificallythe hypothesies that Hispanic women will be more likely to: a. acquire metabolic syndrome and diabetes; b. report more vasomotor symptoms and experience greater distress from them yet seek medical treatment less frequently than other ethnic groups in SWAN . Aim 2 will examine discrepancies between the Hispaniccohort and the rest of SWAN to test the hypotheses that Hispanic women: a. do not view menopause as a medical conditionthat requires treatment; b. utlize more CAM treatment than believed due to lack of ethnically appropriate survey use and c. under-reported calories consumed due to a lack of ethnically appropriate food choices on the surveys used. Aim 3 will explore attitudesand benefits associated with menopause, investigate the conceptual perspective through which women experience menopausal symptoms, and investigate and examine what coping mechanisms and practices are utilized such as CAM and diet through the use of narrative interviews (qualitative research) with Hispanic women. RELEVANCE fSee instructions): The combination of quantitative and qualitative approaches is intended to maximize the information that can be obtained from a difficult-to-recruit and retain population of women for whom retention has been a challenge, and will serve to inform future research dedicated to study of a mixed group of Hispanic women. These findings can be applied to the challenges involved in conducting clinical research in ethnic minorities. PROJECT/

项目总监/首席研究员（最后，第一，中间）：Nanette Santoro 项目摘要（请参阅说明）： 天鹅是全国妇女健康的研究，是一项多种种族的多站点研究 美国活跃了10多年的美国。天鹅 - 新泽西人群的社会经济最低 地位，是基线上最差的健康指标，并遭受了实质性的跟进和障碍 继续研究。尽管大量流失，天鹅 - 新球衣西班牙裔妇女的速度仍然最高 事件代谢综合征和2型糖尿病，并报告更多症状，对其 与天鹅队的其余部分相比，更年期过渡的症状。我们也认识到需要 更好地了解我们关于西班牙裔妇女的数据与其他队列的数据之间的关键差异 使用补充和替代级别的每日热量摄入量的报道。因此，我们提出3 具体目标将专注于剩余的西班牙裔队列成员（n = 150）并寻求整合 探究的定量和定性方法：AIM 1将继续收集定量数据；物理 测量，血液和缩写的调查数据和SCID采访森我们的西班牙裔队列成员将 可能会像可行的天鹅fvhypothess，并特别检验西班牙裔妇女将成为的假设 更可能：获取代谢综合征和糖尿病； b。报告更多的血管舒缩症状并体验更大 与天鹅的其他种族相比，他们的困扰却少于医疗频率。 AIM 2将检查 西班牙酒精与天鹅的其他地区之间存在差异，以检验西班牙裔妇女的假设：不要 将更年期视为需要治疗的医疗状况； b。与由于缺乏的凸轮治疗相比 种族适当的调查使用和c。由于缺乏种族适当的情况而消耗的不足的卡路里 使用的调查中的食物选择。 AIM 3将探索与更年期相关的态度和利益，调查 概念的观点，妇女经历了更年期症状，并研究和检查什么 使用叙事访谈（定性 研究）与西班牙裔妇女。 相关说明）： 定量方法和定性方法的结合旨在最大化可以的信息 可以从难以保留的妇女中获得，保留率一直是 挑战，并将为未来的研究提供致力于研究一群西班牙裔妇女的研究。 这些发现可以应用于在进行少数民族临床研究所涉及的挑战。 项目/