CVD TRENDS 1980 TO 1991--A GENDER SPECIFIC PERSPECTIVE

1980 年至 1991 年 CVD 趋势——特定性别的视角

• 批准号: 2745651
• 负责人: CAROL A. DERBY
• 金额: $ 7.89万
• 依托单位: NEW ENGLAND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2745651
• 关键词: cardiovascular disorder epidemiology; clinical research; coronary disorder; data collection methodology /evaluation; disease /disorder proneness /risk; gender difference; human data; human morbidity; human mortality; stroke

DESCRIPTION: (Adapted from Investigator's Abstract) The proposed study will test hypotheses related to gender differences in cardiovascular mortality trends between 1980 and 1991 in two southeastern New England communities. The Specific Aims are organized under four major topic areas: 1) gender differences in trends from 1980 to 1991 in total event rates, hospital discharge rates, in-hospital case-fatality and out of hospital deaths for coronary heart disease (CHD) and stroke; 2) gender specific analyses of methodological issues which may affect the interpretation of morbidity and mortality surveillance data; 3) gender differences in the presentation, diagnosis, and treatment of CHD and stroke which may influence morbidity and mortality trends; and 4) gender differences in the association between population trends in risk factors and morbidity and mortality trends. These aims will be accomplished using morbidity and mortality data collected by the Pawtucket Heart Health Program between 1980 and 1993, and risk factor data obtained through biennial cross-sectional household health surveys conducted in random samples of residents in the two study communities. Morbidity and mortality data were obtained according to standardized epidemiologic surveillance methods. Hospitalized cases of coronary heart disease and stroke were identified through hospital discharge records and were validated using a standardized diagnostic algorithm based on data abstracted from medical records. Out-of-hospital deaths identified through death certificate data were validated using an algorithm based upon medical history data and information concerning the circumstances of death obtained from informant interviews. Gender specific trends in both age-adjusted and age specific morbidity and mortality will be compared. Trends in rates estimated from events classified according to ICD-9 discharge and death certificate codes will be contrasted with those estimated from cases validated by standardized diagnostic algorithms. Data regarding circumstances of death and in-hospital treatment will be assessed in relation to potential influences on morbidity and mortality trends. Absolute changes over time and average annual percent change over time will be evaluated using linear and log-linear regression techniques. Other analytic methods will include logistic regression and analysis of variance. Expected annual event rates in men and women will be estimated from risk factor data using equations based upon accelerated failure time Weibull models, and the impact of risk factor on mortality rates will be assessed by comparing predicted with actual rates.

描述：（根据调查员的摘要改编）拟议的研究将 与心血管死亡率性别差异有关的测试假设 1980年至1991年之间的趋势在新英格兰东南部两个社区中。 具体目的是在四个主要主题领域中组织的：1）性别 从1980年到1991年的趋势差异在总事件率，医院 出院率，院内竞争和出院率和医院死亡 冠心病（CHD）和中风； 2）性别特定的分析 可能影响发病率解释的方法论问题 死亡率监视数据； 3）演讲中的性别差异， 诊断和治疗冠心病和中风可能会影响发病率和 死亡率趋势； 4）性别差异 危险因素以及发病率和死亡率趋势的人口趋势。 这些目标将使用发病率和死亡率数据来实现 由1980年至1993年之间的Pawtucket心脏健康计划和风险因素 通过两年一次的横截面家庭健康调查获得的数据 在两个研究社区的居民随机样本中进行。 发病率和死亡率数据是根据标准化获得的 流行病学监测方法。 住院的冠心病病例 通过医院出院记录确定疾病和中风 根据数据使用标准化诊断算法验证 从医疗记录中抽象。 通过 使用基于医学的算法验证了死亡证明数据 历史数据和有关死亡情况的信息 来自线人访谈。 年龄调整和年龄特定的发病率的性别特定趋势 将比较死亡率。 事件估计的利率趋势 根据ICD-9的卸货和死亡证书代码分类为 与由标准化验证的案件估计的相比 诊断算法。 有关死亡情况和 将根据潜在影响评估院内治疗 关于发病率和死亡率趋势。 绝对随着时间的变化和平均变化 随时间变化的年百分比将使用线性和 对数线性回归技术。 其他分析方法将包括 逻辑回归和方差分析。 预期年度事件率 在男女中，将使用方程式从风险因素数据中估算 基于加速故障时间Weibull模型以及风险的影响 通过比较预测，将评估死亡率的因素 实际费率。