The role of mu opoid receptors in diet-induced obesity

mu阿片受体在饮食引起的肥胖中的作用

• 批准号: 8102163
• 负责人: Maria J Barnes
• 金额: $ 15.07万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8102163
• 关键词: Accounting; Affect; Animals; Area; Attenuated; Basic Science; Biomedical Research; Cause of Death; Cessation of life; Clinical Research; Development; Diet; Disease; Eating; Energy Intake; Energy Metabolism; Environment; Fatty acid glycerol esters; Feeding behaviors; Gene Expression; Goals; Health; Human; Hyperphagia; Individual; K-Series Research Career Programs; Learning; Leptin; Neuraxis; Neurotransmitter Receptor; North America; Nutrition Disorders; Obesity; Peptides; Play; Population; Research; Research Personnel; Role; Smoking; Structure of nucleus infundibularis hypothalami; Techniques; Testing; Training; United States; insight; mu opioid receptors; preference; receptor

DESCRIPTION (provided by applicant): Obesity is the most common nutritional disorder in North America; it develops when energy intake is greater than energy expenditure. The level of fat in the diet, together with portion size, is thought to play a major role in promoting the number of individuals who are obese. This emphasizes the need to understand the factors that are involved in modulating not only food intake but also the high preference for fat. Of the large number of peptides, neurotransmitters, and receptor populations that affect food intake, only a few have been demonstrated to make animals overeat and increase their fat preference. Included in this list are mu opioid receptors. The precise mechanism(s) by which mu opioid receptors make animals overeat and increase the preference for a high fat diet is unknown. What is know [sic] is that in obese animals, this receptor population is significantly increased in multiple areas of the central nervous system that are known to be involved in feeding behavior. We hypothesize that the increased mu opioid receptors are contributing to the overeating and increased fat preference that is observed in obese animals. The goals of this application are to determine 1)what causes mu opioid receptors to increase in obese animals; 2)potential mechanisms by which mu opioid receptors make aniamls [sic] hyperphagic and increase fat preference; 3)if increased mu opioid receptors potentiates the development of obesity. The results obtained from the studies can provide a potential target to attenuate the overeating and increased fat prefrence [sic] that is observed in humans that are obese. Our research plan will use a multi-disciplinary approach to allow the candiate [sic] of this K01 career development award to learn several techniques while testing the central hypothesis. Each aspect of the research plan will be conducted at Pennington Biomedical Research Center (Baton Rouge, LA). The sponsor (Dr. George A. Bray) and co-sponsors (Drs. Elizabeth Floyd, Gerlinda Hermann and Richard Rogers) along with a highly interactive basic and clinical research environment, will offer the candidate a great training opportunity to facilitate her transition into becoming a successful independent investigator. PUBLIC HEALTH RELEVANCE: Obesity accounts for approximately 100,000 to 300,000 deaths a year, making this disease the second-leading cause of death in the United States second only to smoking. This application will provide new insights into the cause of obesity and provide a target to help alleviate the development of this disease.

描述（由申请人提供）： 肥胖是北美最常见的营养失调症；当能量摄入大于能量消耗时，就会出现这种情况。饮食中的脂肪含量以及份量被认为在增加肥胖人数方面发挥着重要作用。这强调需要了解不仅涉及调节食物摄入量而且还涉及对脂肪的高度偏好的因素。在影响食物摄入的大量肽、神经递质和受体群中，只有少数已被证明会使动物吃得过多并增加其对脂肪的偏好。该列表中包括μ阿片受体。 mu 阿片受体使动物暴饮暴食并增加对高脂肪饮食的偏好的确切机制尚不清楚。已知的是，在肥胖动物中，这种受体数量在中枢神经系统的多个与摄食行为有关的区域显着增加。我们假设μ阿片受体的增加导致了肥胖动物的暴饮暴食和脂肪偏好增加。此应用程序的目标是确定 1) 是什么导致肥胖动物中 mu 阿片受体增加； 2）μ阿片受体使动物[原文如此]贪食并增加脂肪偏好的潜在机制； 3) mu阿片受体的增加是否会加剧肥胖的发生。从研究中获得的结果可以提供一个潜在的目标，以减少在肥胖人群中观察到的暴饮暴食和脂肪偏好增加[原文如此]。我们的研究计划将采用多学科方法，让 K01 职业发展奖的候选人[原文如此]在检验中心假设的同时学习多种技术。研究计划的各个方面将在彭宁顿生物医学研究中心（路易斯安那州巴吞鲁日）进行。赞助商（乔治·A·布雷博士）和共同赞助商（伊丽莎白·弗洛伊德博士、格尔琳达·赫尔曼和理查德·罗杰斯）以及高度互动的基础和临床研究环境，将为候选人提供良好的培训机会，以促进她过渡到成为一名成功的独立调查员。 公共卫生相关性：肥胖每年导致约 100,000 至 300,000 人死亡，使这种疾病成为美国第二大死亡原因，仅次于吸烟。该应用将为肥胖原因提供新的见解，并提供帮助缓解这种疾病发展的目标。