Autoclave for DMU Shared Biomedical Research Facility

DMU 共享生物医学研究设施的高压灭菌器

• 批准号: 10533461
• 负责人: Maria J Barnes
• 金额: $ 5.72万
• 依托单位: DES MOINES UNIV OSTEOPATHIC MEDICAL CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2023-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10533461
• 关键词: 13 year old; Accreditation; Age; Animal Experimentation; Animals; Area; Award; Basic Science; Biochemistry; Biomedical Research; Brain; Cardiovascular system; Communities; Degree program; Diabetes Mellitus; Doctor of Medicine; Ensure; Environment; Equipment; Expenditure; Faculty; Funding; Goals; Graduate Degree; Health Sciences; Health care facility; Hypertension; Immunology; Infrastructure; Iowa; Journals; Knowledge; Laboratories; Mainstreaming; Measures; Medicine; Mentors; Microcomputers; Minor; Modernization; Neurosciences; Oncology; Operative Surgical Procedures; Osteopathic Medicine; Podiatry; Production; Productivity; Publications; Request for Applications; Research; Research Personnel; Research Support; Research Training; Savings; Schools; Science; Secure; Steam; Sterilization; Students; System; Technology; Time; United States National Institutes of Health; Universities; Vision; Water; Water Purification; animal care; biomedical facility; college; experience; experimental study; faculty research; graduate student; medical schools; operation; programs; rapid growth; repaired; research facility; student mentoring; tool; undergraduate student

Abstract The animal research environment at Des Moines University includes a strong group of NIH funded investigators with excellent equipment and staff support housed in a modern animal care facility. A significant weakness of the current experimental capabilities is our 13-year-old autoclave that is connected to a standalone but integrated 50-yr old boiler (no longer in production) and a water purification system. This integrated old equipment frequently breaks down and requires repairs, causing unanticipated expenditures and delays in conducting animal use research. Such breakdowns occur frequently because of the age and condition of the existing autoclave. Autoclaving is the most effective and reliable means of sterilizing laboratory materials. Autoclaves are an indispensable well-established mainstream technology that is used ubiquitously in biomedical facilities to sterilize equipment/products before use in an experiment or to render items non-infectious before disposal. Despite its importance to NIH research, our current autoclave, while well maintained and heavily used, has lost pace with the current state- of-the-art in sensitivity, reliability and timeliness for our animal and general biomedical research. We thereby request funds to purchase a new efficient integrated Steam Sterilizer (autoclave) - an integrated system that includes a microcomputer-controlled steam sterilizer, a steam boiler, a water saving system and a control system - to allow for reliable sterilization of animal and biomedical related research tools/materials to support our Major and Minor users that have a need for this technology. A modern integrated autoclave will support us in ensuring efficient workflows as well as a safe and contamination free vivarium and research environment. An established sustained track record of heavy use over the last thirteen years, frequent publications from the many NIH and externally funded biomedical researcher community and mentored student research and training on Des Moines University’s campus will ensure that the new integrated Steam Sterilizer will pay for itself in research productivity.

抽象的 得梅因大学的动物研究环境包括强大的 NIH 团队 为研究人员提供先进的设备和人员支持，并在现代化的动物护理中心提供资助 当前实验能力的一个显着弱点是我们的 13 岁设备。 连接到独立但集成的 50 年旧锅炉（不再使用）的高压灭菌器 生产）和水净化系统这种集成的旧设备经常发生故障。 停机并需要维修，导致意外支出和动物饲养延误 由于使用年限和状况的原因，此类故障经常发生。 现有高压灭菌器是实验室消毒最有效、最可靠的手段。 高压灭菌器是一种不可或缺的成熟主流技术。 在生物医学设施中普遍存在，用于在实验中使用之前对设备/产品进行消毒 或在处置前使物品不再具有传染性，尽管它对 NIH 研究很重要，但我们的 当前的高压灭菌器虽然维护良好且使用频繁，但已落后于当前状态- 为我们的动物和一般生物医学研究提供最先进的灵敏度、可靠性和及时性。 我们请求资金购买新的高效集成蒸汽灭菌器（高压灭菌器）- 包括微机控制蒸汽灭菌器、蒸汽锅炉、 节水系统和控制系统 - 允许对动物和动物进行可靠的消毒 生物医学相关的研究工具/材料，以支持我们的主要和次要用户 对这项技术的需求将支持我们确保高效。 工作流程以及安全无污染的动物园和研究环境。 在过去十三年中建立了持续的大量使用记录，频繁 来自许多 NIH 和外部资助的生物医学研究人员社区的出版物以及 在得梅因大学校园指导学生研究和培训将确保 新的集成蒸汽灭菌器将在研究生产力方面得到回报。