Abdominal Body Composition, Inflammation and Cardiovascular Diseaase

腹部身体成分、炎症和心血管疾病

• 批准号: 7878573
• 负责人: Matthew A Allison
• 金额: $ 43.71万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7878573
• 关键词: Abdomen; Adipose tissue; African American; Age; Anatomy; Ancillary Study; Asians; Atherosclerosis; Biological Assay; Biological Markers; Body Composition; Body Weight; Body mass index; Calcium; Cardiovascular Diseases; Cardiovascular system; Chinese People; Coronary; Data; Data Set; Databases; Diet; Disease; Disease model; Ethnic Origin; Ethnic group; Event; Fatty acid glycerol esters; Fibrinogen; Future; Gender; Hispanics; Histocompatibility Testing; Homeostasis; Inflammation; Inflammatory; Interleukin-6; Intervention; Intramuscular; Leptin; Link; Location; Lower Extremity; Measurement; Measures; Medial; Mediating; Mediation; Metabolism; Modeling; Modification; Muscle; Not Hispanic or Latino; Obesity; Participant; Peripheral arterial disease; Physical activity; Physiological; Population; Public Health; Research; Research Personnel; Risk Factors; Scanning; Skeletal Muscle; Testing; Thick; Tumor Necrosis Factor-alpha; Visceral; Woman; X-Ray Computed Tomography; abdominal fat; adipokines; adiponectin; age difference; age group; aged; calcification; cardiovascular disorder risk; clinically relevant; cohort; follow-up; indexing; inflammatory marker; insulin sensitivity; men; muscle form; population based; programs; prospective; sex; subcutaneous; therapeutic target; waist circumference

DESCRIPTION (provided by applicant): Obesity is a burgeoning public health problem with the rates of this condition differing by age, sex and ethnicity. The distribution of abdominal fat also differs by ethnic group. For example, compared to non-Hispanic Whites, African Americans have lower levels of visceral fat while having higher body mass index and waist circumference. These differences have important implications for the interpretation of the ethnic-specific relationships between abdominal body composition, inflammation and incident cardiovascular disease events. Notably, the standard anthropometric measure of body mass index cannot discriminate between different kinds or ratios of tissue types comprising the body weight. Accordingly, we propose to evaluate volumetric abdominal body composition in 1,970 men and women aged 45-84 at baseline, who are being studied in an ancillary study to the Multi-Ethnic Study of Atherosclerosis (MESA) for abdominal aortic calcium (AAC) by computed tomography (CT). The MESA has an extensive database of biomarkers and subclinical CVD measures on each participant, who are also being followed for incident CVD events. We propose to measure and calculate 5 discrete volumetric measures of abdominal body composition from the CT scans: subcutaneous fat, visceral fat, intramuscular fat, the visceral fat to visceral cavity ratio and the lean muscle to visceral fat ratio. We will also perform assays for several pertinent measures of inflammation. Using this and existing MESA data, we plan to test the hypothesis that measures of abdominal body composition will be significantly associated with incident coronary and cardiovascular disease events, independent of traditional CVD risk factors, inflammation and subclinical CVD. We will determine if there are differences in this association by age, sex and ethnicity and will also ascertain the influence of selected dietary and physical activity variables. Furthermore, the richness of the augmented MESA dataset will afford the opportunity to discern whether there is clear advantage afforded by the 5 distinct CT measures of body composition over the traditional measures of BMI and WC. This will provide important physiologic and clinically relevant information on the potential therapeutic targets for interventions aimed at reducing CVD risk by altering the composition of fat in different compartments, including skeletal muscle. We are unaware of any other population-based study that is as comprehensive as this to study the stated aims.

描述（由申请人提供）：肥胖是一个新兴的公共卫生问题，其发病率因年龄、性别和种族而异。腹部脂肪的分布也因种族而异。例如，与非西班牙裔白人相比，非裔美国人的内脏脂肪水平较低，但体重指数和腰围较高。这些差异对于解释腹部身体成分、炎症和心血管疾病事件之间的种族特异性关系具有重要意义。值得注意的是，体重指数的标准人体测量不能区分构成体重的不同种类或比例的组织类型。因此，我们建议在基线时评估 1,970 名 45-84 岁男性和女性的腹部体积成分，这些人正在动脉粥样硬化多种族研究 (MESA) 的一项辅助研究中通过计算腹主动脉钙 (AAC) 进行研究。断层扫描（CT）。 MESA 拥有一个广泛的数据库，其中包含每个参与者的生物标志物和亚临床 CVD 测量值，并且还对参与者的 CVD 事件进行跟踪。我们建议通过 CT 扫描测量和计算腹部身体成分的 5 个离散体积测量值：皮下脂肪、内脏脂肪、肌内脂肪、内脏脂肪与内脏腔的比率以及瘦肌肉与内脏脂肪的比率。我们还将对几种相关的炎症指标进行测定。利用这一数据和现有的 MESA 数据，我们计划检验以下假设：腹部身体成分的测量与冠状动脉和心血管疾病事件显着相关，独立于传统的 CVD 危险因素、炎症和亚临床 CVD。我们将确定这种关联是否因年龄、性别和种族而存在差异，还将确定所选饮食和身体活动变量的影响。此外，丰富的增强 MESA 数据集将提供机会辨别 5 种不同的身体成分 CT 测量值是否比传统的 BMI 和 WC 测量值具有明显优势。这将为干预措施的潜在治疗目标提供重要的生理学和临床相关信息，旨在通过改变不同部位（包括骨骼肌）的脂肪成分来降低心血管疾病风险。我们不知道有任何其他基于人群的研究能够像这项研究那样全面地研究既定目标。