Core C - Comparative Organismal Energetics Core

核心 C - 比较有机体能量学核心

• 批准号: 10633290
• 负责人: Daniel L Smith
• 金额: $ 22.53万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633290
• 关键词: Aging; Animal Model; Area; Behavior; Biochemical; Bioenergetics; Biological Aging; Biology of Aging; Body Composition; Caenorhabditis elegans; Communities; Complement; Daphnia; Development; Drosophila genus; Dual-Energy X-Ray Absorptiometry; Eating; Energy Metabolism; Equipment; Genetic; Human Resources; Institution; Intervention; Longevity; Magnetic Resonance; Measures; Methodology; Mission; Modeling; National Institute on Aging; Nutritional; Organism; Procedures; Research; Research Personnel; Resources; Rodent; Services; Shock; Training and Education; Zebrafish; animal model selection; behavioral outcome; comparative; energy balance; functional outcomes; healthspan; improved; instrumentation; microCT; model organism; novel

Project Summary – Comparative Organismal Energetics Core The Comparative Organismal Energetics Core (Organismal Core) provides specialized expertise in the development and utilization of methodologies, state-of-the-art instrumentation and the selection of animal models to facilitate understanding the contribution of energetics to biological aging, including nutritional, genetic, and biochemical interventions that impact aging research. The Organismal Core is a unique resource for investigators, with services and resources not available elsewhere on campus and available to the broader (non-UAB) research community. The Organismal Core is ideally suited to measure energy acquisition, storage, and utilization in a variety of animal models including C. elegans, Daphnia, Drosophila, zebrafish, and rodents, thereby complementing the overall mission and theme of the UAB Nathan Shock Center (NSC). The Specific Aims of the Core are as follows: 1. To provide expertise in the area of energetics and body composition in comparative animal models of aging; 2. To provide state-of-the-art instrumentation and methodology for the determination of body composition across the lifespan (dual energy X-ray absorptiometry, quantitative magnetic resonance, and micro- computed tomography); 3. To provide state-of-the-art instrumentation and methodology for the determination of energy balance across the lifespan (food intake, energy expenditure, energy balance, and activity); 4. To provide state-of-the-art instrumentation and methodology for evaluating healthspan-associated behaviors across lifespan and species; 5. To develop new methodologies for assessing energetics/body composition where needed in current and novel organisms for aging research; 6. To provide education and training on procedures and pitfalls in comparative organismal energetics (both internal and external to UAB).

项目摘要 - 比较生物的能量核心 比较生物的能量核心（生物核心）提供了专业的专业知识 方法的开发和利用，最先进的仪器和动物的选择 促进能量对生物衰老的贡献的模型，包括营养 影响衰老研究的遗传和生化干预措施。生物核心是独特的资源 对于调查人员，校园其他地方都无法提供服务和资源，并且更广泛 （非UAB）研究社区。有机体核心非常适合测量能量采集，存储， 以及在各种动物模型中的利用 从而完成UAB Nathan Shock Center（NSC）的整体任务和主题。具体 核心的目的如下： 1。在比较动物模型中提供能量和身体成分领域的专业知识 老化; 2。提供最新的仪器和方法来确定身体成分 在整个寿命中 计算机断层扫描）； 3。提供最先进的仪器和方法来确定能量平衡 跨越寿命（食物摄入，能量消耗，能量平衡和活动）； 4。提供最新的仪器和方法来评估与健康相关的 跨越寿命和物种的行为； 5。开发新方法来评估当前需要的情况下的能量/身体组成 衰老研究的新颖生物； 6。在比较有机能源中提供有关程序和陷阱的教育和培训（都 内部和外部的UAB）。