WHITE MATTER DAMAGE IN AGE-RELATED COGNITIVE DECLINE

与年龄相关的认知衰退中的白质损伤

• 批准号: 8357822
• 负责人: Larry S. Sherman
• 金额: $ 5.82万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357822
• 关键词: Age-associated memory impairment; Alzheimer' s Disease; Blood Vessels; Cognition Disorders; Funding; Goals; Grant; Hyaluronan; Impaired cognition; Metabolism; National Center for Research Resources; Oxidative Stress; Patients; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Testing; United States National Institutes of Health; brain tissue; cognitive change; cost; white matter damage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this project is to test how oxidative stress, vascular changes, cognitive changes and alterations in hyaluronan metabolism correlate in patients with vascular cognitive impairment, Alzheimer's disease, and other cognitive disorders compared to unaffected patients. This project focuses on characterizing changes in hyaluronan metabolism in brain tissues from these patients.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该项目的目的是测试血管认知障碍，阿尔茨海默氏病以及其他认知障碍的患者透明质酸代谢的氧化应激，血管变化，认知变化和变化如何相关的患者。 该项目的重点是表征这些患者脑组织中透明质酸代谢的变化。