NEUROENDOCRINE CONTROL OF FEMALE PUBERTY

女性青春期的神经内分泌控制

• 批准号: 8357726
• 负责人: Sergio R Ojeda
• 金额: $ 5.82万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357726
• 关键词: Affect; Brain; Cell Communication; Cells; Communication; Competence; Epidermal Growth Factor; Family; Female; Funding; Genes; Genomics; Gonadotropin Hormone Releasing Hormone; Grant; Growth Factor; Hormones; Human; Hypothalamic structure; Mediating; Mutant Strains Mice; National Center for Research Resources; Nervous system structure; Neuraxis; Neuroglia; Neurons; Neurosecretory Systems; Play; Primates; Principal Investigator; Process; Proteins; Proteomics; Puberty; Regulatory Pathway; Research; Research Infrastructure; Resources; Role; Sexual Development; Source; Syndrome; System; United States National Institutes of Health; cost; reproductive; Affect; Brain; Cell Communication; Cells; Communication; Competence; Epidermal Growth Factor; Family; Female; Funding; Genes; Genomics; Gonadotropin Hormone Releasing Hormone; Grant; Growth Factor; Hormones; Human; Hypothalamic structure; Mediating; Mutant Strains Mice; National Center for Research Resources; Nervous system structure; Neuraxis; Neuroglia; Neurons; Neurosecretory Systems; Play; Primates; Principal Investigator; Process; Proteins; Proteomics; Puberty; Regulatory Pathway; Research; Research Infrastructure; Resources; Role; Sexual Development; Source; Syndrome; System; United States National Institutes of Health; cost; reproductive

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. These studies examine the role that cell-cell communication within the brain plays in the control of female puberty. The concept is being developed that reciprocal communication between neurons (one of the two main functional and structural units of the central nervous system) and astroglial cells (the other main building block of the nervous system) is critical for the timely acquisition of female sexual maturity and reproductive competence. We have identified several components of this glia-neuron regulatory system and elucidated some of the intercellular mechanisms they employ to transfer information from astroglial cells to the neurons that secrete luteinizing hormone-releasing hormone (LHRH), the hormone controlling female sexual development. A family of growth factors related to a protein known as epidermal growth factor (EGF) was found to be produced by astroglial cells and to function interactively to facilitate LHRH secretion and, thus, regulate the initiation of the pubertal process. Using mutant mice in which the normal function of these pivotal recognition molecules mediating the actions of EGF-related proteins was impaired, we demonstrated that these astroglial-derived growth factors are required for normal female sexual development. We have also used genomic and proteomic approaches to identify new genes that, expressed in the hypothalamus, participate in the control of the pubertal process. Altogether these results provide support for the concept that the syndromes of sexual precocity and delayed sexual development of central origin in humans may be related to abnormalities affecting these major regulatory pathways.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 这些研究研究了细胞 - 细胞在大脑中控制雌性青春期的作用。这一概念正在发展，即神经元（中枢神经系统的两个主要功能和结构单位之一）与星形胶质细胞（神经系统的另一个主要构件）之间的相互交流对于及时获得女性性成熟和生殖能力至关重要。我们已经确定了该神经胶质神经元调节系统的几个组成部分，并阐明了他们采用的一些细胞间机制将信息从星形胶质细胞转移到神经元转移到神经元中，这些神经元分泌了黄体生成激素释放激素激素（LHRH），即激素控制女性性行为。发现与称为表皮生长因子（EGF）的蛋白质有关的生长因子家族是由星形胶质细胞产生的，并可以交互作用以促进LHRH分泌，因此调节了青春期过程的开始。使用突变小鼠，其中这些关键识别分子的正常功能介导了与EGF相关蛋白的作用受到损害，我们证明了正常女性性发育需要这些星形胶质细胞来源的生长因子。我们还使用了基因组和蛋白质组学方法来识别下丘脑中表达的新基因，参与了对青春期过程的控制。总的来说，这些结果为性早熟综合症和人类中心起源的延迟性发展的综合症提供了支持，可能与影响这些主要调节途径的异常有关。