UREAPLASMA INFECTION IN UTERO: PREVENTION OF NEUROLOGIC SEQUELAE

子宫内脲原体感染：预防神经系统后遗症

• 批准号: 8357809
• 负责人: Peta Louise Grigsby
• 金额: $ 3.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357809
• 关键词: Anti-Inflammatory Agents; Anti-inflammatory; Antibiotics; Caring; Cerebrum; Critical Care; Encephalitis; Funding; Genital system; Grant; Infant Care; Inflammation; Intake; Liquid substance; Macaca mulatta; Medical; Mycoplasma; National Center for Research Resources; Neonatal; Neurologic; Neuronal Injury; Newborn Infant; Nurseries; Oxygen; Premature Birth; Prevention; Primates; Principal Investigator; Procedures; Protocols documentation; Research; Research Infrastructure; Research Proposals; Resources; Source; United States National Institutes of Health; Ureaplasma Infections; Veterinarians; cost; fetal; in utero; intraamniotic infection; neurobehavioral; postnatal; prenatal; respiratory; white matter; white matter injury

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objectives of this research proposal are to delineate the extent of cerebral white matter inflammation and neuronal injury caused by genital mycoplasmas (U. parvum) and to assess the efficacy of maternal antibiotic plus anti-inflammatory therapy in ameliorating fetal brain inflammation and neuronal injury. It is our hypothesis that prenatal treatment of U. parvum intra-amniotic infection (IAI) with specific antibiotics and appropriate anti-inflammatory agents will delay preterm delivery and mitigate fetal origins of neonatal cerebral white matter injury. To facilitate our studies, it is necessary to expand the scope of newborn infant care at the ONPRC by establishing a special care nursery (SCN) that will support postnatal survival of prematurely born rhesus monkeys and specific neurobehavioral assessment protocols to study postnatal neurologic sequelae. With medical direction from collaborating academic neonatologists and ONPRC veterinarians, we developed critical care management plans (i.e., respiratory support, supplemental oxygen, i.v fluids and intakes), as well as standard operating procedures to assure optimal chance of neonatal survival.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 本研究计划的目的是描述生殖器支原体（U. parvum）引起的脑白质炎症和神经元损伤的程度，并评估母体抗生素加抗炎治疗在改善胎儿脑部炎症和神经元损伤方面的功效。我们的假设是，用特定抗生素和适当的抗炎药对细小 U. parvum 羊膜内感染 (IAI) 进行产前治疗将延迟早产并减轻胎儿起源的新生儿脑白质损伤。为了促进我们的研究，有必要通过建立特殊护理托儿所（SCN）来扩大 ONPRC 的新生儿护理范围，以支持早产恒河猴的产后生存，并建立特定的神经行为评估方案来研究产后神经系统后遗症。在合作的学术新生儿学家和 ONPRC 兽医的医疗指导下，我们制定了重症监护管理计划（即呼吸支持、补充氧气、静脉输液和摄入量）以及标准操作程序，以确保新生儿的最佳生存机会。