UREAPLASMA INFECTION IN UTERO: PREVENTION OF NEUROLOGIC SEQUELAE

子宫内脲原体感染：预防神经系统后遗症

• 批准号: 8173301
• 负责人: Peta Louise Grigsby
• 金额: $ 4.76万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173301
• 关键词: Anti-Inflammatory Agents; Anti-inflammatory; Antibiotics; Caring; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Critical Care; Encephalitis; Funding; Genital system; Grant; Inflammation; Institution; Macaca mulatta; Medical; Mycoplasma; Neonatal; Neurologic; Neuronal Injury; Nurseries; Premature Birth; Prevention; Procedures; Protocols documentation; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Ureaplasma Infections; Veterinarians; fetal; in utero; intraamniotic infection; neurobehavioral; postnatal; prenatal; white matter; white matter injury

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this research are to delineate the extent of cerebral white matter inflammation and neuronal injury caused by genital mycoplasmas (U. parvum) and to assess the efficacy of maternal antibiotic plus anti-inflammatory therapy in ameliorating fetal brain inflammation and neuronal injury. It is our hypothesis that prenatal treatment of U. parvum intra-amniotic infection (IAI) with specific antibiotics and appropriate anti-inflammatory agents will delay preterm delivery and mitigate fetal origins of neonatal cerebral white matter injury. To facilitate our studies we will establish a special care nursery (SCN) that will support postnatal survival of prematurely born rhesus monkeys and specific neurobehavioral assessment protocols to study postnatal neurologic sequelae. With medical direction from collaborating academic neonatologists and ONPRC veterinarians, we will develop critical care management plans, as well as standard operating procedures neonatal care.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是描述由生殖器支原体（U. parvum）引起的脑白质炎症和神经元损伤的程度，并评估孕产妇抗生素加抗炎疗法在胎儿脑炎症和神经元损伤中的疗效。我们的假设是，用特定的抗生素和适当的抗炎剂对U. parvum U. parvum养殖内感染（IAI）的治疗将延迟早产递送并减轻新生儿白质损伤的胎儿起源。为了促进我们的研究，我们将建立一个特殊的护理苗圃（SCN），该托儿所将支持过早出生的恒河猴和特定的神经行为评估方案，以研究产后神经系统后遗症。通过合作的学术新生学家和ONPRC兽医的医疗指导，我们将制定重症监护管理计划以及标准的操作程序新生儿护理。