Genes, Prenatal Drug Exposure, and the Postnatal Environment: An Adoption Study

基因、产前药物暴露和产后环境：一项收养研究

基本信息

批准号：
7840534
负责人：
Jenae M. Neiderhiser
金额：
$ 94.85万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-15 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7840534
关键词：
Adolescent Adoption Adult Age Alcohol consumption Alcohol or Other Drugs use Alcoholism Alcohols Amphetamines Attention Behavior Biological Birth Characteristics Child Child Behavior Child Development Child Rearing Childhood Cognitive Collection Conflict (Psychology)DNA Dependence Development Developmental Delay Disorders Disease Drug abuse Drug usage Environment Environmental Risk Factor Exposure to Family Family Process Family Study Fathers Fetus Fortune Genes Genetic Genetic Research Genetic Risk Goals Growth and Development function High Prevalence Individual Inhalant dose form Intervention Knowledge Link Longitudinal Studies Marijuana Smoking Measurement Measures Mediating Methods Molecular Genetics Mothers Neurologic Parents Participant Pathway interactions Pharmaceutical Preparations Positioning Attribute Postpartum Period Pregnancy Pregnancy Complications Prevalence Prevention Preventive Problem behavior Public Health Recruitment Activity Reporting Research Research Design Research Personnel Risk Sampling Smoke Solutions Specific qualifier value Substance abuse problem Symptoms Tobacco Toddler Twin Multiple Birth Variant Woman adopted child cocaine exposure design drug abuse prevention drug of abuse early childhood experience fetal drug exposure genetic risk factor indexing intergenerational non-drug postnatal prenatal prenatal exposure problem drinker programs prospective research study tool transmission process young adult

项目摘要

DESCRIPTION (provided by applicant): The proposed research study seeks to use and expand an existing prospective longitudinal adoption study, the Early Growth and Development Study (EGDS: R01HD42608) to better understand how genetic factors, prenatal drug exposure, and postnatal rearing environment operate together to influence toddler development, and ultimately, an individual's risk of later drug use. We propose to recruit 200 yoked adoption units (birth parents and adoptive families linked through the adopted child - approximately 866 individuals) and to capitalize on the existing 350 yokes recruited by the EGDS study. The 550 total yokes (approximately 2,382 individuals) will provide sufficient power to examine possible interactions among genes, prenatal drug exposure and postnatal rearing environment that EGDS was not designed to study. Using the same assessment strategy and measurement as EGDS, the new 200 yokes will be followed longitudinally and DNA will be collected from all participants in the full sample of 550 yokes. This expanded sample and longitudinal assessment, combined with the collection of DNA, enables the examination of the following specific aims: (SA1) Understanding how genetic risk for later drug use is expressed behaviorally in the toddler period; (SA2) Estimating prenatal exposure effects independent of genetic risk; (SA3) Estimating postnatal family environmental effects independent of genetic risk and prenatal exposure; and (SA4) Clarifying how genetic risk and prenatal exposure to drugs are moderated by postnatal family environment. Integrating the three possible mechanisms of the transmission of drug abuse to children - genetic, prenatal exposure and postnatal environment - has important potential for informing public health. Specifically, the proposed study is designed to disentangle the effects of genetic, prenatal and postnatal environmental factors on early child development and to examine interactions and correlations among these factors. This will help guide intervention efforts aimed at the prevention of drug abuse in children of drug-dependent or drug-abusing parents by identifying which postnatal family environmental factors have the most impact on ameliorating risk from genetic and prenatal exposure factors.

描述（由申请人提供）：拟议的研究旨在利用和扩展现有的前瞻性纵向收养研究，即早期生长和发育研究（EGDS：R01HD42608），以更好地了解遗传因素、产前药物暴露和产后抚养环境如何运作共同影响幼儿的发育，并最终影响个人以后吸毒的风险。我们建议招募 200 个有轭收养单位（通过被收养的孩子联系起来的亲生父母和收养家庭 - 大约 866 人），并利用 EGDS 研究招募的现有 350 个有轭收养单位。总共 550 个轭（约 2,382 个个体）将提供足够的能力来检查基因、产前药物暴露和产后饲养环境之间可能的相互作用，而 EGDS 并不是为研究而设计的。使用与 EGDS 相同的评估策略和测量，将纵向跟踪新的 200 个轭，并从 550 个轭的完整样本中的所有参与者收集 DNA。这种扩大的样本和纵向评估，与 DNA 的收集相结合，可以检查以下具体目标： (SA1) 了解后期吸毒的遗传风险如何在幼儿时期以行为方式表达； (SA2) 估计与遗传风险无关的产前暴露影响； (SA3) 估计独立于遗传风险和产前暴露的产后家庭环境影响； (SA4) 阐明产后家庭环境如何调节遗传风险和产前药物暴露。整合药物滥用向儿童传播的三种可能机制——遗传、产前暴露和产后环境——对于为公众健康提供信息具有重要潜力。具体来说，拟议的研究旨在理清遗传、产前和产后环境因素对儿童早期发育的影响，并检查这些因素之间的相互作用和相关性。通过确定哪些产后家庭环境因素对改善遗传和产前暴露因素的风险影响最大，这将有助于指导旨在预防吸毒或吸毒父母的儿童吸毒的干预措施。