Targeted Approaches to Weight Control for Young Adults Grant with RCU Proposal

RCU 提案为年轻人提供有针对性的体重控制方法

• 批准号: 8296227
• 负责人: KAREN C JOHNSON
• 金额: $ 95.16万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-17 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8296227
• 关键词: Address; Attenuated; Behavior; Behavioral; Body Weight decreased; Cardiovascular Diseases; Chronic Disease; Cigarette Smoker; Clinical Trials; Development; Diet; Eating Behavior; Enrollment; Grant; Health Benefit; Intervention; Literature; Morbidity - disease rate; Obesity; Overweight; Participant; Persons; Physical activity; Public Health; Reporting; Risk Factors; Smoker; Technology; Testing; Tobacco; Weight Gain; Weight maintenance regimen; abstracting; age group; cardiovascular disorder risk; cigarette smoking; comparison group; group intervention; high risk; mortality; prevent; programs; quitline; sedentary; smoking cessation; weight loss intervention; young adult

DESCRIPTION (provided by applicant): Obesity represents a chronic disease associated with significant cardiovascular disease (CVD) morbidity and mortality. Weight gain in young adults adversely impacts the development of CVD risk factors. Further, there is a clear relationship between weight loss in obese persons and reduction in these CVD risk factors. Unfortunately, young adults are at high risk for weight gain. Although the scientific literature contains a number of reports regarding successful weight loss efficacy studies, young adults are typically underrepresented. Cigarette smoking is the leading preventable cause of morbidity and mortality, but quitting smoking results in significant weight gain. Tobacco quit lines have been shown to help persons quit smoking. However, concerns about post-cessation weight gain have been reported as a significant barrier to quitting. If an efficacious behavioral weight loss program could be combined with an efficacious behavioral smoking cessation program that prevented post-cessation weight gain, then a large public health benefit may result. Such a combined weight loss / smoking cessation program that used targeted intervention strategies to young adults, removed barriers to participation, and utilize interactive technology should be appealing to this age group. To date such a combined program has not been tested in young overweight and obese cigarette smokers trying to quit. Therefore, the objective of this clinical trial is to develop and test a behavioral weight loss intervention delivered through interactive technology that can be used in conjunction with an efficacious tobacco quit line (QL). A total of 330 participants will be necessary to adequately address the following specific aims: Primary Aim: We hypothesize that an efficacious proactive tobacco quit line plus a behavioral weight loss intervention delivered through interactive technology (Intervention Group) will significantly attenuate or prevent weight gain associated with smoking cessation at 2 years after enrollment compared to a proactive tobacco quit line alone (Comparison Group) in young overweight and obese smokers. Secondary Aims: We also plan to assess changes between the groups in: a.) Biochemically verified smoking cessation; b.) Diet and eating behavior; and c.) Physical activity. (End of Abstract)

描述（由申请人提供）：肥胖是一种与显着心血管疾病（CVD）发病率和死亡率相关的慢性疾病。年轻人体重增加对心血管疾病危险因素的发展产生不利影响。此外，肥胖者的体重减轻与这些 CVD 危险因素的减少之间存在明显的关系。不幸的是，年轻人体重增加的风险很高。尽管科学文献包含许多有关成功减肥功效研究的报告，但年轻人的代表性通常不足。吸烟是发病率和死亡率的主要可预防原因，但戒烟会导致体重显着增加。戒烟热线已被证明可以帮助人们戒烟。然而，据报道，对戒烟后体重增加的担忧是戒烟的重大障碍。如果有效的行为减肥计划可以与有效的行为戒烟计划相结合，以防止戒烟后体重增加，那么可能会产生巨大的公共健康效益。这种针对年轻人采用针对性干预策略、消除参与障碍并利用互动技术的减肥/戒烟综合计划应该会吸引这个年龄段的人。迄今为止，这种联合计划尚未在试图戒烟的年轻超重和肥胖吸烟者中进行过测试。因此，该临床试验的目的是开发和测试通过交互式技术提供的行为减肥干预措施，该干预措施可以与有效的戒烟热线（QL）结合使用。总共需要 330 名参与者才能充分实现以下具体目标： 主要目标：我们假设有效的主动戒烟热线加上通过互动技术（干预组）提供的行为减肥干预措施将显着减轻或防止相关的体重增加与年轻超重和肥胖吸烟者单独主动戒烟（比较组）相比，入组后 2 年戒烟。次要目标：我们还计划评估各组之间在以下方面的变化：a.）经生化验证的戒烟； b.) 饮食和饮食行为； c.) 体力活动。 （摘要完）