RF Technology Innovation for Advancing High Field MR.

推进高场 MR 的射频技术创新。

• 批准号: 8217132
• 负责人: YUDONG ZHU
• 金额: $ 70.42万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8217132
• 关键词: Address; Algorithms; Animals; Behavior; Body Image; Breast; Calibration; Clinical; Computer Analysis; Computer software; Deposition; Detection; Development; Diagnosis; Effectiveness; Error Sources; Frequencies; Goals; Head; Heating; Human; Image; In Situ; Investigation; Lead; Maps; Measurement; Measures; Methodology; Methods; Metric; Modeling; Monitor; Pancreas; Pattern; Performance; Physiologic pulse; Positioning Attribute; Process; Prostate; RF coil; Radio; Research; Resolution; Safety; Scanning; Signal Transduction; Solutions; Speed; Structure; System; Technology; Test Result; Tissues; Translating; Variant; advanced disease; base; clinical practice; design; disease diagnosis; experience; image reconstruction; improved; in vivo; innovation; insight; magnetic field; novel strategies; operation; prototype; public health relevance; research study; simulation; tool; transmission process; trend

DESCRIPTION (provided by applicant): An important trend in MR in recent years has been the move towards higher magnetic field (B0) strengths, which promises to advance disease understanding and diagnosis with enhancements in detection sensitivity, metabolite resolution, imaging speed, and tissue contrast. However there are technical challenges that severely hamper the practice of human high field MR, including a major one that accompanies the creation of MR signal using radio frequency EM fields - B1 and concomitant E fields. As B0 strength increases, the degradation in B1 homogeneity due to increased wave behavior often causes severe image quality issues. Meanwhile E-induced RF heating of the subject body (SAR) poses increasingly inhibiting constraints on the application of high-performance MR sequences. With a great capacity for alleviating the limitations imposed by B1 inhomogeneity and SAR exacerbation, parallel RF transmit is emerging as a key enabling technology for high field MR. This project aims at significantly improving human high field MR capability and safety by creating innovative solutions to spin excitation, RF apparatus, and RF energy deposition in subjects. This will be accomplished with specific efforts on a) developing a much needed non-invasive method for measuring, predicting, and proactively managing SAR, b) leveraging the method in optimizing parallel excitation pulses and in breaking new ground of 7T MR applications, and c) transforming RF hardware and pulse designs to considerably boost high field MR system performance. The successful completion of this project will lead to quantitative / predictive methods that enable the fulfillment of the full potential of in vivo imaging at high field, high impact body imaging applications, and innovative RF methods that promise to bring signal creation and detection performance to a new level. PUBLIC HEALTH RELEVANCE: This project will create a vital RF solution to human high field MR, and will enable the fulfillment of the full potential of high field MR in the detection and diagnosis of diseases.

描述（由申请人提供）：近年来 MR 的一个重要趋势是向更高的磁场 (B0) 强度发展，这有望通过增强检测灵敏度、代谢物分辨率、成像速度和组织来促进疾病理解和诊断对比。然而，存在严重阻碍人类高场 MR 实践的技术挑战，其中包括使用射频 EM 场（B1 和伴随 E 场）创建 MR 信号所伴随的主要挑战。随着 B0 强度的增加，由于波行为增加而导致 B1 均匀性下降，通常会导致严重的图像质量问题。与此同时，电磁感应射频加热主体 (SAR) 对高性能 MR 序列的应用造成越来越多的限制。 并行射频传输能够极大地缓解 B1 不均匀性和 SAR 加剧带来的限制，因此正在成为高场 MR 的关键实现技术。该项目旨在通过创建自旋激发、射频设备和受试者射频能量沉积的创新解决方案，显着提高人类高场磁共振能力和安全性。这将通过以下方面的具体努力来实现：a) 开发一种急需的非侵入性方法来测量、预测和主动管理 SAR，b) 利用该方法优化并行激励脉冲并开辟 7T MR 应用的新领域，以及 c ) 改造射频硬件和脉冲设计，显着提升高场 MR 系统性能。 该项目的成功完成将带来定量/预测方法，这些方法能够在高场、高影响人体成像应用中充分发挥体内成像的潜力，以及创新的射频方法，有望将信号创建和检测性能带到一个领域。新水平。 公共健康相关性：该项目将为人类高场 MR 创建重要的射频解决方案，并将充分发挥高场 MR 在疾病检测和诊断方面的潜力。