Animal & Instrumentation Core

动物

• 批准号: 7998964
• 负责人: Thomas Heppner
• 金额: $ 43.83万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7998964
• 关键词: Actins; Age; Animal Experiments; Animals; Astrocytes; Biosensor; Boxing; Breeding; Caliber; Caring; Cerebrum; Clip; Communication; Communities; Contracts; Databases; Date of birth; Disease; Doxycycline; Ear; Endothelial Cells; Endothelium; Ensure; Equipment; Figs - dietary; Food; Gel; Gender; Genetic; Genotype; Glial Fibrillary Acidic Protein; Goals; Heterozygote; Individual; Laboratories; Location; Mails; Methods; Monitor; Mouse Strains; Mus; Online Systems; Operative Surgical Procedures; Population; Power Sources; Progress Reports; Rattus; Regulation; Research; Research Personnel; Research Project Grants; Schedule; Scheme; Security; Services; Signal Transduction; Smooth Muscle; Smooth Muscle Myocytes; Specific qualifier value; System; Tail; Tetracyclines; Time; Tissues; Transgenic Mice; Transgenic Organisms; Universities; Vermont; Water; Weaning; Work; animal care; base; drinking water; feeding; instrumentation; meetings; mouse development; mouse model; novel; offspring; overexpression; programs; promoter; ratiometric; sex; success

The overall goal of the Program Project is to understand mechanisms regulating the cerebral vasculature in normal and disease states. All four projects that constitute this PPG are focused on this goal, and each recognizes that experimental success depends on the proper isolation of tissue from euthanized animals, careful implementation of surgical procedures and appropriate post-op care. The top priority of the Animal & Instrumentation Core is. to enhance the success of research projects for each investigator. This includes providing a central means for handling animal populations, ensuring proper conditions for surgical use, and maintaining excellent post-op care of animals. By centralizing these tasks, which are common to all projects, the Animal & Instrumentation Core allows investigators to focus on experimental issues and management unique to each project to enhance experimental success.

该计划项目的总体目标是了解正常和疾病状态下脑血管系统的调节机制。构成该 PPG 的所有四个项目都专注于这一目标，并且每个项目都认识到实验的成功取决于从安乐死动物中正确分离组织、仔细实施外科手术以及适当的术后护理。动物和仪器核心的首要任务是。提高每位研究者研究项目的成功率。这包括提供处理动物种群的核心手段、确保手术使用的适当条件以及对动物进行良好的术后护理。通过集中所有项目共有的这些任务，动物和仪器核心使研究人员能够专注于每个项目特有的实验问题和管理，以提高实验成功率。