Mechanical Response of Biological Tissue to Shock Waves

生物组织对冲击波的机械响应

• 批准号: 8291363
• 负责人: Robin Cleveland
• 金额: $ 17.21万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8291363
• 关键词: Accounting; Acoustics; Acute; Adverse effects; Algorithms; Biological; Blood capillaries; Body Surface; Calculi; Cell Nucleus; Chronic; Clinical; Clinical Data; Code; Data; Devices; Diabetes Mellitus; Elasticity; Electromagnetics; Ensure; Family suidae; Fire - disasters; Fracture; Frequencies; Funding; Gases; Goals; Growth; Hematoma; Hypertension; Imaging problem; In Vitro; Individual; Injury; Injury to Kidney; Islet Cell; Islets of Langerhans; Kidney; Kidney Calculi; Laws; Life; Link; Liquid substance; Literature; Lithotripsy; Location; Lung; Measurement; Measures; Mechanics; Mediating; Membrane; Methods; Modeling; Motion; Movement; Outcome; Output; Pancreas; Process; Program Research Project Grants; Property; Relaxation; Resistance; Respiration; Risk; Role; Shock; Signal Transduction; Simulate; Source; Staging; Stress; Testing; Time; Tissue Model; Tissues; Transducers; Tube; Ultrasonography; Vertebral column; Viscosity; Water; attenuation; base; capillary; improved; in vivo; insight; mathematical model; models and simulation; new technology; physical property; pressure; research study; response; simulation; technology development; tissue phantom; tool; vapor; vasoconstriction; virtual

Shock wave lithotripsy (SWL) revolutionized the treatment of kidney stones when it was introduced in the 1980s. However, the subsequent development of the technology has shown little improvement in clinical outcomes, such as stone free rate. Further there have been studies indicating an association with chronic complications in particular new onset hypertension and diabetes mellitus. Progress within the current funding period has identified strategies by which shock waves can be delivered with reduced acute tissue damage. The goal of Project 4 is to investigate the fundamental mechanisms of tissue damage, both to the kidney, where the PPG has confirmed its extent and identified possible chronic implication, and in the pancreas. In Aim 1 we will extend a current numerical simulation tool to predict the acoustic insult of a lithotripter to the kidney and pancreas. This tool will be used extensively to provide input data for other aims. In Aim 2, will evaluate a hypothesis developed by this group that the direct effect of repeated shocks on the tissue might initiate injury. Preliminary results from a mathematical model predict that this damage will be more important in the inner medulla where injury is first observed experimentally. In Aim 3 we will use our advanced modeling and simulation tools to understand the mediating factors in cavitation induced injury. Experimental evidence of cavitation in tissue is unambiguous, but the mechanisms by which it damages tissue and the reasons why it appears suppressed during the first few hundred shock waves are unclear. Aim 4 will apply the tools developed in the previous 3 aims to assess the acoustic insult and subsequent tissue injury to the pancreas in order to gain insight into the risk of lithotripsy inducing diabetes. Aim 5 is motivated by data from the PPG that indicates that a broad focal zone lithotripter can suppress injury and at the same time improve stone fragmentation. The goal will be to understand the physical properties of the acoustic field which result in reduced tissue damage but with effective fragmentation. Aim 6 exploits data that shows many shock waves do not hit the stone but they will still impact tissue. We plan to develop a device that can track stone location and gate current lithotripters to ensure that shock waves are only fired when the stone is on target. By reducing the number of off-target shock waves the insult to the tissue will be reduced. The overarching goal of Project 4 is to provide a strategy for shock wave lithotripsy to be delivered with fewer side effects by a combination of understanding the fundamental mechanics of the tissue damage process and developing novel technologies which will reduce the shock wave impact.

冲击波碎石术 (SWL) 被引入美国后，彻底改变了肾结石的治疗方法。 20 世纪 80 年代。但该技术的后续发展在临床上却没有什么改善。 结果，例如结石清除率。此外，还有研究表明与慢性 并发症，特别是新发高血压和糖尿病。目前的进展 资助期间已确定了可以通过减少急性组织来传递冲击波的策略 损害。项目 4 的目标是研究组织损伤的基本机制，无论是对 肾，PPG 已确认其范围并确定了可能的慢性影响，并且在 胰腺。在目标 1 中，我们将扩展当前的数值模拟工具来预测 肾脏和胰腺碎石机。该工具将广泛用于为其他工具提供输入数据 目标。在目标 2 中，将评估该小组提出的假设，即重复冲击的直接影响 组织上可能会引发损伤。数学模型的初步结果预测这种损害 在首先通过实验观察到损伤的内部髓质中更为重要。在目标 3 中我们将使用 我们先进的建模和模拟工具可了解空化引起的损伤的中介因素。 组织中空化现象的实验证据是明确的，但其损害的机制 组织及其在最初几百个冲击波中受到抑制的原因尚不清楚。 目标 4 将应用前 3 个目标中开发的工具来评估声损伤和后续目标 胰腺组织损伤，以深入了解碎石术诱发糖尿病的风险。目标 5 是 受到 PPG 数据的启发，该数据表明宽焦区碎石机可以抑制损伤，并且 同时提高石材破碎度。目标是了解物理特性 声场可减少组织损伤，但可有效破碎。目标 6 利用数据 这表明许多冲击波不会击中石头，但仍会冲击组织。我们计划开发一个 可以跟踪结石位置和控制电流碎石机以确保仅发射冲击波的装置 当石头击中目标时。通过减少脱靶冲击波的数量，对组织的损伤将减少 减少。项目 4 的总体目标是提供一种实施冲击波碎石术的策略 通过结合了解组织损伤的基本机制，可以减少副作用 过程和开发新技术，以减少冲击波的影响。