Mechanical Response of Biological Tissue to Shock Waves

生物组织对冲击波的机械响应

• 批准号: 7759402
• 负责人: Robin Cleveland
• 金额: $ 23.25万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7759402
• 关键词: Accounting; Acoustics; Acute; Adverse effects; Algorithms; Biological; Blood capillaries; Body Surface; Calculi; Cell Nucleus; Chronic; Clinical; Clinical Data; Code; Data; Devices; Diabetes Mellitus; Elasticity; Electromagnetics; Ensure; Family suidae; Fire - disasters; Fracture; Frequencies; Funding; Gases; Goals; Growth; Hematoma; Hypertension; Imaging problem; In Vitro; Individual; Injury; Injury to Kidney; Islet Cell; Islets of Langerhans; Kidney; Kidney Calculi; Laws; Life; Link; Liquid substance; Literature; Lithotripsy; Location; Lung; Measurement; Measures; Mechanics; Mediating; Membrane; Methods; Modeling; Motion; Movement; Outcome; Output; Pancreas; Process; Program Research Project Grants; Property; Relaxation; Resistance; Respiration; Risk; Role; Shock; Signal Transduction; Simulate; Source; Staging; Stress; Testing; Time; Tissue Model; Tissues; Transducers; Tube; Ultrasonography; Vertebral column; Viscosity; Water; attenuation; base; capillary; improved; in vivo; insight; mathematical model; models and simulation; new technology; physical property; pressure; research study; response; simulation; technology development; tissue phantom; tool; vapor; vasoconstriction; virtual

Shock wave lithotripsy (SWL) revolutionized the treatment of kidney stones when it was introduced in the 1980s. However, the subsequent development of the technology has shown little improvement in clinical outcomes, such as stone free rate. Further there have been studies indicating an association with chronic complications in particular new onset hypertension and diabetes mellitus. Progress within the current funding period has identified strategies by which shock waves can be delivered with reduced acute tissue damage. The goal of Project 4 is to investigate the fundamental mechanisms of tissue damage, both to the kidney, where the PPG has confirmed its extent and identified possible chronic implication, and in the pancreas. In Aim 1 we will extend a current numerical simulation tool to predict the acoustic insult of a lithotripter to the kidney and pancreas. This tool will be used extensively to provide input data for other aims. In Aim 2, will evaluate a hypothesis developed by this group that the direct effect of repeated shocks on the tissue might initiate injury. Preliminary results from a mathematical model predict that this damage will be more important in the inner medulla where injury is first observed experimentally. In Aim 3 we will use our advanced modeling and simulation tools to understand the mediating factors in cavitation induced injury. Experimental evidence of cavitation in tissue is unambiguous, but the mechanisms by which it damages tissue and the reasons why it appears suppressed during the first few hundred shock waves are unclear. Aim 4 will apply the tools developed in the previous 3 aims to assess the acoustic insult and subsequent tissue injury to the pancreas in order to gain insight into the risk of lithotripsy inducing diabetes. Aim 5 is motivated by data from the PPG that indicates that a broad focal zone lithotripter can suppress injury and at the same time improve stone fragmentation. The goal will be to understand the physical properties of the acoustic field which result in reduced tissue damage but with effective fragmentation. Aim 6 exploits data that shows many shock waves do not hit the stone but they will still impact tissue. We plan to develop a device that can track stone location and gate current lithotripters to ensure that shock waves are only fired when the stone is on target. By reducing the number of off-target shock waves the insult to the tissue will be reduced. The overarching goal of Project 4 is to provide a strategy for shock wave lithotripsy to be delivered with fewer side effects by a combination of understanding the fundamental mechanics of the tissue damage process and developing novel technologies which will reduce the shock wave impact.

冲击波岩石疗法（SWL）在肾结石中引入时彻底改变了肾结石的处理。 1980年代。但是，该技术的随后发展显示临床几乎没有改善 结果，例如无石费率。此外，有研究表明与慢性 并发症特别是新发作高血压和糖尿病。电流的进展 资金期已经确定了可以通过减少急性组织传递冲击波的策略 损害。项目4的目的是研究组织损伤的基本机制 肾脏，PPG已确认其程度并确定了可能的慢性含义，在 胰腺。在AIM 1中，我们将扩展一个当前的数值模拟工具，以预测 岩石和胰腺的岩石磨牙。该工具将广泛使用以提供其他 目标。在AIM 2中，将评估该组提出的假设，即重复冲击的直接影响 在组织上可能会引发受伤。数学模型的初步结果预测了这种损害 在首先通过实验观察到损伤的内部延髓将更为重要。在AIM 3中，我们将使用 我们的高级建模和模拟工具，以了解空化诱导损伤中的中介因子。 在组织中空气的实验证据是明确的，但是它损坏的机制 组织及其在前几百个冲击波中似乎被抑制的原因尚不清楚。 AIM 4将应用上3个旨在评估声学侮辱和随后的工具中开发的工具 胰腺的组织损伤，以深入了解岩性疗法诱导糖尿病的风险。目标5是 由来自PPG的数据激励，表明宽阔的焦点区域岩石膜可以抑制伤害，并在 同时改善石材碎片。目标是了解 声场导致组织损伤减少但有效碎裂。 AIM 6利用数据 这表明许多冲击波不会撞到石头，但仍会影响组织。我们计划开发一个 可以跟踪石头位置和门流电流岩石磨牙器以确保仅发射冲击波的设备 当石头在目标上时。通过减少脱靶冲击波的数量，对组织的侮辱将是 减少。项目4的总体目标是为要交付的冲击波碎石术提供策略 通过了解组织损伤的基本力学的结合，副作用较少 处理和开发新型技术，这将减少冲击波影响。