Energy Dysregulation: Behavioral and Biological Signals

能量失调：行为和生物信号

基本信息

批准号：
8544651
负责人：
TERRY L DAVIDSON
金额：
$ 14.36万
依托单位：
AMERICAN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-17 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8544651
关键词：
Energy Dysregulation Behavioral Biological Signals

项目摘要

DESCRIPTION (provided by applicant): The Surgeon General has stated that environmental and lifestyle changes may hold the most promise for the treatment of obesity. Gaps in knowledge about the physiological and behavioral control mechanisms on which dietary and environmental factors operate impede progress toward effective therapies. Thus, the goal of this Program Project is to integrate multi-disciplinary perspectives to investigate, using both human and rodent models, the environmental basis of obesity. It seems clear that under conditions where highly palatable, energy-rich, food is available continuously, energy balance depends on the ability to inhibit eating when food or stimuli associated with food are present. Examining how information provided by the cue properties of food can inhibit ingestive behavior is the central aim of this program project, with individual projects examining three levels of inhibitory control. First, inhibition of food intake may depend on the ability of orosensory stimuli, such as taste and flavor, to signal the nutritive consequences of eating. We will investigate the idea that animals use these sensory properties to anticipate the nutritive impact of foods, and that impairing this anticipatory response disturbs energy regulation. Second, we will study how signals that are detected by post-oral, gastrointestinal sensors are transmitted to the brain to suppress eating, and how the functions of these gut cues is influenced by dietary factors. Finally, the information provided by orosensory and gastrointestinal signals must be integrated and processed by the brain to produce adaptive behavioral outcomes. We will investigate the possibilities that inhibition of eating and appetitive behavior relies on the hippocampus, a brain structure that appears to play an important role in behavioral inhibition, and that certain dietary factors may promote energy dysregulation by impairing hippocampal function. Expertise in psychological, behavioral, biological, and food sciences will be integrated with the aim of discovering specific behavioral or dietary interventions that could strengthen or reinstate adaptive inhibitory control over eating and thus, ameliorate, stop, or reverse current trends toward obesity. An Administrative Core will provide statistical consulting, data management and other organizational support and will monitor and evaluate all program activities. The Analytical Core will oversee, coordinate, and standardize technological and behavior assays that are used by all Program Project personnel.

描述（由申请人提供）：外科医生表示，环境和生活方式的改变可能最有希望治疗肥胖。关于饮食和环境因素起作用的生理和行为控制机制的知识差距阻碍了有效治疗的进展。因此，该计划项目的目标是整合多学科视角，利用人类和啮齿动物模型来调查肥胖的环境基础。似乎很清楚，在可口性高、能量丰富、持续提供食物的条件下，能量平衡取决于存在食物或与食物相关的刺激时抑制进食的能力。研究食物提示特性提供的信息如何抑制摄入行为是该计划项目的中心目标，各个项目检查三个级别的抑制控制。首先，食物摄入的抑制可能取决于口腔感觉刺激（例如味道和风味）发出饮食营养结果信号的能力。我们将研究这样一种观点：动物利用这些感官特性来预测食物的营养影响，而损害这种预期反应会扰乱能量调节。其次，我们将研究口腔后胃肠传感器检测到的信号如何传输到大脑以抑制进食，以及这些肠道信号的功能如何受到饮食因素的影响。最后，口腔感觉和胃肠道信号提供的信息必须由大脑整合和处理，以产生适应性的行为结果。我们将研究抑制进食和食欲行为依赖于海马体的可能性，海马体是一种似乎在行为抑制中发挥重要作用的大脑结构，并且某些饮食因素可能通过损害海马体功能而促进能量失调。心理学、行为、生物和食品科学方面的专业知识将与发现特定的行为或饮食干预措施相结合，这些干预措施可以加强或恢复对饮食的适应性抑制控制，从而改善、阻止或逆转当前的肥胖趋势。行政核心将提供统计咨询、数据管理和其他组织支持，并将监测和评估所有计划活动。分析核心将监督、协调和标准化所有计划项目人员使用的技术和行为分析。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Influence of ovarian hormones on development of ingestive responding to alterations in fatty acid oxidation in female rats.

卵巢激素对雌性大鼠脂肪酸氧化变化的摄食发育的影响。

DOI：
10.1016/j.yhbeh.2008.05.009
发表时间：
2008
期刊：
Hormones and behavior
影响因子：
3.5
作者：
Swithers,SusanE;McCurley,Melissa;Hamilton,Erica;Doerflinger,Alicia
通讯作者：
Doerflinger,Alicia

Body weight gain in rats consuming sweetened liquids. Effects of caffeine and diet composition.

食用加糖液体的老鼠体重增加。

DOI：
10.1016/j.appet.2010.08.021
发表时间：
2010
期刊：
Appetite
影响因子：
5.4
作者：
Swithers,SusanE;Martin,AshleyA;Clark,KielyM;Laboy,AlyciaF;Davidson,TL
通讯作者：
Davidson,TL

Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats.

DOI：
10.1016/j.bbr.2012.04.024
发表时间：
2012-07-15
期刊：
BEHAVIOURAL BRAIN RESEARCH
影响因子：
2.7
作者：
Swithers, Susan E.;Laboy, Alycia F.;Clark, Kiely;Cooper, Stephanie;Davidson, T. L.
通讯作者：
Davidson, T. L.

High-intensity sweeteners and energy balance.