Mid-Career Mentoring Award for Patient-Oriented Research in Aging

以患者为导向的老龄化研究职业中期指导奖

• 批准号: 8316195
• 负责人: EDWARD R MARCANTONIO
• 金额: $ 19.1万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8316195
• 关键词: Acute; Address; Affect; Aging; Anesthesia procedures; Area; Award; Biological Markers; Blood; Blood specimen; Cardiac Surgery procedures; Caring; Clinical; Cognitive; Commit; Comorbidity; Confusion; Death Rate; Delirium; Development; Diagnosis; Diagnostic; Diagnostic Procedure; Elderly; Environment; Enzyme-Linked Immunosorbent Assay; Epidemiology; Functional disorder; Funding; Future; Genetic Materials; Gerontology; Goals; Health; Health Care Costs; Hip Fractures; Hospitals; Incidence; Individual; Inflammatory; Inpatients; Interdisciplinary Study; Intervention; Investigation; Israel; Knowledge; Lead; Length of Stay; Mass Spectrum Analysis; Measures; Medical; Medical center; Medicine; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Monitor; Morbidity - disease rate; Operative Surgical Procedures; Outcome; Participant; Patients; Plasma; Plasma Proteins; Postoperative Period; Primary Health Care; Procedures; Proteins; Proteomics; Quality of Care; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Resolution; Resources; Risk; Risk Factors; Sampling; Series; Severities; Severity of illness; Stratification; Structure; System; Techniques; Testing; Time; Training; Translational Research; United States National Institutes of Health; Validation; Work; career; career development; clinical epidemiology; cost; cytokine; functional outcomes; functional status; high risk; improved; interdisciplinary collaboration; interest; medical schools; modifiable risk; mortality; patient oriented; patient oriented research; prevent; professor; programs; repaired; repository; skills; tool

PROJECT SUMMARY/ABSTRACT: I, Edward R. Marcantonio, MD, SM, am a board-certified geriatrician and patient-oriented aging researcher, Associate Professor of Medicine at Harvard Medical School (HMS) and Director of Research in the Division of General Medicine and Primary Care at Beth Israel Deaconess Medical Center (BIDMC). The long term objectives of my career are to conduct patient-oriented research (POR) to improve the quality of care and outcomes of hospitalized older adults, and to provide mentoring to new investigators interested in POR in aging. Over the past 16 years, I have built a successful, independent, NIH-funded program of research focused on delirium (acute confusion), a common, morbid and costly condition in hospitalized older adults. I have conducted a series of observational and interventional studies designed to improve diagnosis, target individuals at risk, identify modifiable risk factors, and test intervention strategies to reduce the incidence, severity and duration of delirium. Through these studies, I have gained the knowledge and skills necessary to conduct high quality POR and to mentor new investigators, and have been recognized for my excellence in mentoring with two prestigious awards. In this context, the primary objectives of this K24 Award are: 1. To continue to build a research program around improving the quality and outcomes of care for hospitalized older adults with delirium. This objective will be accomplished through my currently funded studies, including an NIA-funded R01 entitled 3D-CAM: Deriving and validating a 3-Minute Diagnostic Assessment for Delirium, and my new research, a Biomarker Discovery for Delirium project described in this application. Receipt of the K24 will enable me to more effectively leverage these studies and other ongoing work to support the work of trainees, who will in turn expand my research program. 2. To build a mentorship program that will expand POR in aging at BIDMC and HMS, with a focus on delirium and related conditions. This objective will be accomplished through structured, individual mentorship of young investigators with a strong interest in POR. Protected time for mentorship will be provided by the K24 award. 3. To expand my mentorship program to include translational, interdisciplinary work around biomarker discovery for delirium, and biomarker applications to improve risk stratification, diagnosis, and prognostication of older adults with delirium. This objective will be accomplished through my new research project, career development activities, and interdisciplinary collaborations that will be facilitated by receipt of the K24 award. My objectives will be greatly facilitated by the superb academic environment and outstanding institutional support provided by HMS and the BIDMC Divisions of General Medicine and Gerontology.

项目摘要/摘要： I，Edward R. Marcantonio，医学博士，SM，A是董事会认证的老年医生和以患者为导向的老龄化研究员， 哈佛医学院（HMS）医学副教授和研究主任 贝丝以色列执事医疗中心（BIDMC）的普通医学和初级保健。长期 我职业的目标是进行以患者为导向的研究（POR），以提高护理质量和 住院老年人的结果，并向对POR感兴趣的新调查人员提供指导 老化。在过去的16年中，我建立了一项成功，独立，NIH资助的研究计划 专注于del妄（急性混乱），这是住院老年人常见，病态且昂贵的状况。我 已经进行了一系列旨在改善诊断的观察和介入研究 处于危险中的个人，确定可修改的危险因素以及测试干预策略以减少发病率， del妄的严重性和持续时间。通过这些研究，我获得了必要的知识和技能 进行高质量的POR并指导新的调查员，并因我的卓越表现而受到认可 通过两个享有盛誉的奖项进行指导。在这种情况下，该K24奖的主要目标是： 1。继续建立围绕改善住院治疗的质量和护理结果的研究计划 老年人患有ir妄。这个目标将通过我当前资助的研究来完成，包括 NIA资助的R01标题为3D-CAM：得出和验证3分钟的诊断评估 以及我的新研究，这是该应用程序中描述的del妄项目的生物标志物发现。收到 K24将使我能够更有效地利用这些研究和其他正在进行的工作来支持 受训者，后来将扩大我的研究计划。 2。建立一个指导计划，该计划将扩大BIDMC和HMS的衰老，重点是 和相关条件。这个目标将通过年轻的结构化的个人指导来实现 对POR有浓厚兴趣的调查员。受保护的指导时间将由K24奖提供。 3。扩大我的指导计划以包括围绕生物标志物的翻译，跨学科工作 del妄和生物标志物应用的发现，以改善风险分层，诊断和预后 老年人患有ir妄的老年人。这个目标将通过我的新研究项目实现 开发活动和跨学科合作将通过获得K24奖的促进。 精湛的学术环境和杰出的机构将极大地促进我的目标 由HMS提供的支持以及通用医学和老年医学的BIDMC师。