Degeneration of motoneurons caudal to spinal lesion

脊髓病变尾部运动神经元变性

基本信息

批准号：
8301092
负责人：
WILLIAM Zev RYMER
金额：
$ 23.11万
依托单位：
REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-02-01 至 2014-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8301092
关键词：
Action Potentials Acute Amyotrophic Lateral Sclerosis Articular Range of Motion Atrophic Cervical spinal cord injury Cessation of life Chronic Clinical Contracture Data Development Diagnosis Diagnostic Disease Disease Progression Electric Stimulation Electrodes Frequencies Functional disorder Goals Hand Knowledge Lesion Longitudinal Studies Measurement Measures Mechanics Mediating Methods Motor Motor Neurons Movement Muscle Muscle Fibers Muscle Weakness Muscle fasciculation Muscle function Needles Neurologic Outcome Paralysed Paresis Pattern Pharmaceutical Preparations Prevalence Process Property Quadriplegia Rehabilitation device Relative (related person)Research Rest Skeletal Muscle Spastic Spinal Spinal Injuries Spinal cord injury Spinal cord injury patients Structure Surface Techniques Testing Time base density effective therapy improved indexing motor impairment nerve supply novel rehabilitation strategy reinnervation restoration white matter damage

项目摘要

DESCRIPTION (provided by applicant): The long-term goals of the proposed project are to understand the complicated origins of the spinal cord injury (SCI) induced muscle paresis, atrophy, weakness, and muscle contractures that often result in a limited range of joint motion and progressive changes in intrinsic muscle mechanical properties. In particular, our proposed research plan relies on several recently developed novel surface electromygram (EMG) techniques to investigate controversial concepts about caudal motoneuron degeneration after a spinal injury. Using motor unit number index measurements and high-density surface EMG recording and processing techniques, we will determine whether motor unit structure and function changes of paralyzed muscles, potentially due to caudal motoneuron degeneration, can be captured via three specific aims. Namely, we plan to assess whether there is evidence for motoneuron degeneration caudal to spinal injury using estimates of motor unit numbers in paralyzed muscles (Aim 1), and using the recorded spontaneous EMG activities in resting paralyzed muscles (Aim 2). In addition, we will examine alterations in motor unit action potential propagation patterns and innervation zones, as a marker of motoneuron loss and subsequent muscle fiber reinnervation in paralyzed muscles, thus providing secondary evidence for motoneuron degeneration caudal to spinal injury (Aim 3). The methods used in this study are noninvasive, potentially convenient to use, and offer valuable information beyond that provided by needle-based EMG and other routine electrophysiological methods. The findings from these novel methods will enhance our understanding of the pathophysiology of potential motoneuron degeneration in SCI. This will provide guidance for the development of rehabilitation strategies and devices for restoration of normal muscle functions. The findings from this study also have important clinical value for the diagnosis and treatment of spinal injury, improve outcome measurements, and help evaluate the effects of medication or therapies. PUBLIC HEALTH RELEVANCE: The proposed examination of spinal cord injury (SCI) patients using several novel surface EMG techniques will add new knowledge for understanding the complicated origins of the SCI induced muscle paresis, atrophy, weakness, contracture and other muscle mechanical changes, thus in turn providing guidance for the development of rehabilitation strategies and devices for restoration of normal muscle functions. The findings from the project will also have important clinical value to diagnosis and treatment of motor impairments from spinal injury.

描述（由申请人提供）：拟议项目的长期目标是了解脊髓损伤（SCI）诱发的肌肉减轻，萎缩，无力和肌肉缩合的复杂起源，这些肌肉，萎缩，无力和肌肉缩水通常会导致关节运动的有限范围和内在的肌肉机械特性的内在变化。特别是，我们提出的研究计划依赖于最近开发的新型表面肌数据（EMG）技术来研究有关脊柱损伤后尾动物神经元变性的有争议的概念。使用电动机单位编号指数测量和高密度表面EMG记录和处理技术，我们将确定是否可以通过三个特定目标来捕获瘫痪肌肉的运动单位结构和瘫痪肌肉功能变化。也就是说，我们计划使用瘫痪肌肉中运动单位数量的估计值（AIM 1），并使用记录的自发性EMG活性在静止的瘫痪肌肉中使用运动神经元变性的尾骨尾部尾骨（AIM 2）（AIM 2）。此外，我们将研究运动单位动作电势传播模式和神经支配区域的变化，作为运动神经元丧失的标志以及随后的瘫痪肌肉的肌肉纤维纤维增强，从而为脊柱损伤提供了次要的次要证据（AIM 3）。这项研究中使用的方法是无创的，潜在的使用，并提供了基于针的EMG和其他常规电生理方法提供的有价值的信息。这些新方法的发现将增强我们对SCI潜在运动神经元变性的病理生理学的理解。这将为恢复正常肌肉功能的康复策略和设备的制定提供指导。这项研究的发现还具有重要的临床价值，用于诊断和治疗脊柱损伤，改善结果测量并帮助评估药物或疗法的影响。公共卫生相关性：使用几种新型表面EMG技术对脊髓损伤（SCI）患者的拟议检查将增加新的知识，以了解SCI诱导的肌肉减少，萎缩，弱点，缔合和其他肌肉机械变化的复杂起源，从而为恢复正常肌肉功能的恢复恢复策略和设备的发展提供指导。该项目的发现还将具有重要的临床价值，以诊断和治疗脊柱损伤的运动障碍。