ENGINEERING FOR NEUROLOGIC REHABILITATION

神经康复工程

• 批准号: 6983551
• 负责人: WILLIAM Zev RYMER
• 金额: $ 75.33万
• 依托单位: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-23 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6983551
• 关键词: bioengineering /biomedical engineering; biomechanics; biomedical equipment development; biomedical facility; clinical biomedical equipment; computational neuroscience; computer simulation; electrodes; electromyography; electrophysiology; gait; medical rehabilitation related tag; nervous system disorder diagnosis; nervous system disorder therapy; neurosciences; rehabilitation; spinal cord injury; stroke; stroke therapy; telemetry

DESCRIPTION (provided by applicant): This infrastructure research core called "Engineering for Neurological Rehabilitation" seeks to expand and disseminate the PIs core expertise in engineering and in neuroscience to help support the development of new faculty in medical centers, and hospitals across the United States. This program will build on core facilities established in the PIs center under the auspices of the current regional research (R24) network and under analogous, NIDRR-sponsored research centers supporting robotics research for stroke and other neurological disorders. These core facilities include the following (1) A Robotics/Mechanics Core, directed by James Patton, Yasin Dhaher, and Sandro Mussa-lvaldi. The PIs plan to make available for collaborative research an array of different robotic and mechanical systems designed for fundamental research, for diagnostic studies, and for testing therapeutic approaches in stroke and spinal cord injury. These robots include upper extremity robotics systems such as the MIT Manus, an RIC planar machine called the reaching guide, the Phantom, and WAM, a novel backdriveable three-dimensional robotics system. In addition, new robotic systems such as the Haptic Master and other special-purpose robots will also be made available for collaborative interaction, once they are integrated into the PIs' research programs. In addition, gait studies using the "Lokomat" as both a diagnostic and therapeutic tool will be made available to collaborators for pilot studies. (2) An Information Technology Core, directed by Li-Qun Zhang and Derek Kamper. This core facility has the capacity to build novel electronic systems such as state-of-the-art EMG electrodes, telemetered collection systems, advancing signal processing systems, and extensive modeling and simulation facilities. (3) A Neurosciences Core, directed by C.J. Heckman and George Hornby. Dr. Heckman directs a research laboratory dealing with animal models of spinal cord injury using electrophysiological, anatomical, immunohistochemical, chemical, and pharmacological approaches. This laboratory will be available to pursue studies preparatory to human testing. Other approaches available include the use of electrophysiological testing using H reflexes, and transcranial magnetic stimulation for study of spinal cord circuitry and excitability. Availability of these research cores, as well as other core development projects, will be disseminated through dedicated websites and presented at national and international meetings. The PIs also plan to offer short- or long-term sabbatical opportunities to collaborate in studies using these various cores. Finally, a series of didactic courses, hands-on workshops, and symposia will also be offered to present novel research themes in these engineering areas.

描述（由申请人提供）：这个名为“神经康复工程”的基础设施研究核心旨在扩展和传播 PI 在工程和神经科学方面的核心专业知识，以帮助支持美国各地医疗中心和医院新教师的发展。该计划将建立在 PI 中心建立的核心设施之上，这些设施由当前区域研究 (R24) 网络和 NIDRR 赞助的类似研究中心支持，支持中风和其他神经系统疾病的机器人研究。这些核心设施包括以下 (1) 机器人/力学核心，由 James Patton、Yasin Dhaher 和 Sandro Mussa-lvaldi 指导。 PI 计划为合作研究提供一系列不同的机器人和机械系统，这些系统旨在用于基础研究、诊断研究以及测试中风和脊髓损伤的治疗方法。这些机器人包括上肢机器人系统，例如 MIT Manus（一种称为到达引导器的 RIC 平面机器）、Phantom 和 WAM（一种新型可反向驱动的三维机器人系统）。此外，新的机器人系统，如 Haptic Master 和其他专用机器人，一旦集成到 PI 的研究项目中，也将可用于协作交互。此外，使用“Lokomat”作为诊断和治疗工具的步态研究将提供给合作者进行试点研究。 (2) 信息技术核心，由张立群和德里克·坎珀指导。该核心设施有能力构建新型电子系统，例如最先进的肌电图电极、遥测收集系统、先进的信号处理系统以及广泛的建模和模拟设施。 (3) 神经科学核心，由 C.J. Heckman 和 George Hornby 指导。 Heckman 博士领导一个研究实验室，利用电生理学、解剖学、免疫组织化学、化学和药理学方法处理脊髓损伤的动物模型。该实验室将可用于进行人体测试的准备研究。其他可用的方法包括使用 H 反射进行电生理测试，以及用于研究脊髓回路和兴奋性的经颅磁刺激。这些研究核心以及其他核心开发项目的可用性将通过专门网站传播并在国家和国际会议上介绍。 PI 还计划提供短期或长期的休假机会，以便利用这些不同的核心进行研究合作。最后，还将提供一系列教学课程、实践研讨会和研讨会，以展示这些工程领域的新颖研究主题。