ENGINEERING FOR NEUROLOGIC REHABILITATION

神经康复工程

• 批准号: 6983551
• 负责人: WILLIAM Zev RYMER
• 金额: $ 75.33万
• 依托单位: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-23 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6983551
• 关键词: bioengineering /biomedical engineering; biomechanics; biomedical equipment development; biomedical facility; clinical biomedical equipment; computational neuroscience; computer simulation; electrodes; electromyography; electrophysiology; gait; medical rehabilitation related tag; nervous system disorder diagnosis; nervous system disorder therapy; neurosciences; rehabilitation; spinal cord injury; stroke; stroke therapy; telemetry

DESCRIPTION (provided by applicant): This infrastructure research core called "Engineering for Neurological Rehabilitation" seeks to expand and disseminate the PIs core expertise in engineering and in neuroscience to help support the development of new faculty in medical centers, and hospitals across the United States. This program will build on core facilities established in the PIs center under the auspices of the current regional research (R24) network and under analogous, NIDRR-sponsored research centers supporting robotics research for stroke and other neurological disorders. These core facilities include the following (1) A Robotics/Mechanics Core, directed by James Patton, Yasin Dhaher, and Sandro Mussa-lvaldi. The PIs plan to make available for collaborative research an array of different robotic and mechanical systems designed for fundamental research, for diagnostic studies, and for testing therapeutic approaches in stroke and spinal cord injury. These robots include upper extremity robotics systems such as the MIT Manus, an RIC planar machine called the reaching guide, the Phantom, and WAM, a novel backdriveable three-dimensional robotics system. In addition, new robotic systems such as the Haptic Master and other special-purpose robots will also be made available for collaborative interaction, once they are integrated into the PIs' research programs. In addition, gait studies using the "Lokomat" as both a diagnostic and therapeutic tool will be made available to collaborators for pilot studies. (2) An Information Technology Core, directed by Li-Qun Zhang and Derek Kamper. This core facility has the capacity to build novel electronic systems such as state-of-the-art EMG electrodes, telemetered collection systems, advancing signal processing systems, and extensive modeling and simulation facilities. (3) A Neurosciences Core, directed by C.J. Heckman and George Hornby. Dr. Heckman directs a research laboratory dealing with animal models of spinal cord injury using electrophysiological, anatomical, immunohistochemical, chemical, and pharmacological approaches. This laboratory will be available to pursue studies preparatory to human testing. Other approaches available include the use of electrophysiological testing using H reflexes, and transcranial magnetic stimulation for study of spinal cord circuitry and excitability. Availability of these research cores, as well as other core development projects, will be disseminated through dedicated websites and presented at national and international meetings. The PIs also plan to offer short- or long-term sabbatical opportunities to collaborate in studies using these various cores. Finally, a series of didactic courses, hands-on workshops, and symposia will also be offered to present novel research themes in these engineering areas.

描述（由申请人提供）：这个称为“神经康复工程”的基础设施研究核心旨在扩展和传播工程和神经科学领域的PIS核心专业知识，以帮助支持医疗中心的新教师的发展，以及美国各地的医院。该计划将建立在当前区域研究（R24）网络的主持下，以及在类似的NIDRR赞助的研究中心的主持下建立的核心设施，支持中风和其他神经系统疾病的机器人研究中心。这些核心设施包括以下（1）由James Patton，Yasin Dhaher和Sandro Mussa-Lvaldi执导的机器人/力学核心。 PIS计划用于协作研究，一系列用于基础研究，用于诊断研究以及测试中风和脊髓损伤的治疗方法的不同机器人和机械系统。这些机器人包括上肢机器人系统，例如MIT MANUS，一种称为“触及指南”的RIC平面机，幻影和WAM，这是一种新颖的背景三维机器人系统。此外，一旦将它们整合到PIS的研究计划中，新的机器人系统（例如触觉主和其他特殊用途机器人）也将用于协作互动。此外，使用“ Lokomat”作为诊断和治疗工具的步态研究将提供给合作者进行试点研究。 （2）由Li-Qun Zhang和Derek Kamper执导的信息技术核心。该核心设施具有构建新型电子系统的能力，例如最先进的EMG电极，遥测收集系统，推进信号处理系统以及广泛的建模和仿真设施。 （3）由C.J. Heckman和George Hornby执导的神经科学核心。 Heckman博士指挥了一项研究实验室，该研究实验室使用电生理，解剖学，免疫组织化学，化学和药理学方法来处理脊髓损伤动物模型。该实验室将可用于为人类测试做准备的研究。可用的其他方法包括使用H反射的电生理测试，以及用于研究脊髓回路和兴奋性的经颅磁刺激。这些研究核心以及其他核心开发项目的可用性将通过专门的网站传播，并在国家和国际会议上介绍。 PI还计划提供短期或长期休假的机会，以使用这些核心进行研究。最后，还将提供一系列教学课程，动手研讨会和研讨会，以在这些工程领域介绍新的研究主题。