Diagnostics Development Core

诊断开发核心

基本信息

批准号：
8377038
负责人：
Richard Willson
金额：
$ 51.1万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-03-01 至 2014-02-28
项目状态：
已结题

项目摘要

The WRCE Diagnostics Development Core supports and enhances the efficiency of diagnostics development projects within the WRCE by providing common access to generally-applicable technologies, shared reagents and animal models, BSL-3 and BSL-4 testing of diagnostics, and specialized consulting services. Two Diagnostics Workshops will be organized by the Diagnostics Development Core. Animal challenge samples from vaccine and therapeutic projects will be harvested by the Core for efficient testing of diagnostic technologies. Technology development activities include the development of specialized molecular recognition reagents (e.g., antibodies and aptamers) for neglected pathogens, and microfluidics tools for the conversion of laboratory assays into practical diagnostic platforms. Shared reagents and animal models are economically more efficient, conserve animals, and enhance inter- and intralaboratory comparisons of experimental diagnostics with gold standards and with each other. Moreover, we believe that common use of the core facilities by the RCE investigators will have the additional benefit of promoting scientific dialog beyond the boundaries of the individual laboratories. Central access to the Core's BSL-3 and BSL-4 testing facilities allows realistic testing of candidate diagnostics with virulent agents that would be difficult or even impossible for the individual investigator to access at reasonable cost. Finally, specialized advice on the translation of laboratory technologies into a genuinely useful platform diagnostic test will be provided by an experienced consultant to all diagnostics theme investigators.

WRCE诊断开发核心核心支持和提高诊断的效率 WRCE内的开发项目通过提供对普遍适用技术的共同访问，共享试剂和动物模型，BSL-3和BSL-4诊断测试以及专业咨询服务。诊断开发核心将组织两个诊断研讨会。动物疫苗和治疗项目的挑战样本将由核心收获，以有效测试诊断技术。技术开发活动包括专业的开发分子识别试剂（例如，抗体和适体）用于被忽视的病原体和微流体剂将实验室测定转换为实用诊断平台的工具。共享试剂和动物模型在经济上更有效，保护动物，并增强室内和室内的效率实验诊断与黄金标准和彼此的比较。而且，我们相信 RCE调查人员对核心设施的共同使用将为促进带来额外的好处科学对话超出了各个实验室的边界。中心访问核心的BSL-3和 BSL-4测试设施允许对具有强毒剂的候选诊断进行现实测试，这将是个人调查员很难以合理的成本访问。最后，专业关于将实验室技术翻译成真正有用的平台诊断测试的建议将是由所有诊断主题调查人员的经验丰富的顾问提供。