Acid Ceramidase, Ceramide and Farber Disease

酸性神经酰胺酶、神经酰胺和法伯病

• 批准号: 8038520
• 负责人: EDWARD H. SCHUCHMAN
• 金额: $ 25.41万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-15 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8038520
• 关键词: 16 year old; 4-Hydroxy-Tamoxifen; Animals; Apoptosis; Birth; Breeding; Cattle; Cells; Ceramides; Complementary DNA; Culture Media; Cystatins; Development; Embryo; Embryonic Development; Enzymes; Event; Farber' s lipogranulomatosis; Fertilization; Fertilization in Vitro; Funding; Gene Silencing; Genes; Goals; Human; In Vitro; Knock-in Mouse; Knock-out; Knockout Mice; Knowledge; Length; Metabolism; Modeling; Mothers; Mus; Mutation; Oocytes; Organ; Outcome; Pathogenesis; Phenotype; Process; Proteins; Published Comment; Purkinje Cells; Recombinants; Regulation; Request for Applications; Research; Residual state; Role; Signal Transduction; Sphingolipids; Staging; Transgenes; Transgenic Mice; Work; base; cDNA Expression; clinically relevant; galactosylgalactosylglucosylceramidase; human disease; in vivo; inhibitor/antagonist; insight; macrophage; mouse development; mouse model; novel; novel strategies; older patient; oocyte maturation; pregnant; prevent; promoter; pup; recombinase; tool; translational medicine; uptake