Biochemical Analysis Core

生化分析核心

• 批准号: 8299954
• 负责人: Juan C Romero
• 金额: $ 17.68万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8299954
• 关键词: 3-nitrotyrosine; Angiotensin II; Animals; Antioxidants; Biochemical; Creatinine; Data; Human; Injury; Isoprostanes; Kidney; NADPH Oxidase; Oxidative Stress; Plasma; Potassium; Renin; Renovascular Hypertension; Sampling; Sodium; Tissue Sample; Tissues; dihydroethidium

Core C is responsible for the biochemical analysis of markers of oxidative stress in plasma and tissue samples generated from the experimental animal and human studies. Determinations of plasma samples will include Plasma Renin Activity (PRA) and content (PRC), Angiotensin II (ANG II), Isoprostane (free), Total Antioxidant Capacity, Creatinine, and sodium/ potassium. In addition, tissue analysis of Angiotensin II, Nitrotyrosine, NADPH oxidase (p47), Isoprostane (total) and dihydroethidium (DHE) will be performed. This data will give important information about the relationship between renal humoral factors, oxidative stress, and renovascular hypertension.

Core C 负责血浆和组织中氧化应激标志物的生化分析 从实验动物和人类研究中产生的样本。血浆样品的测定将 包括血浆肾素活性 (PRA) 和含量 (PRC)、血管紧张素 II (ANG II)、异前列烷（游离）、总量 抗氧化能力、肌酐和钠/钾。此外，血管紧张素 II 的组织分析， 将进行硝基酪氨酸、NADPH 氧化酶 (p47)、异前列烷（总计）和二氢乙锭 (DHE)。这 数据将提供有关肾体液因素、氧化应激和肾病之间关系的重要信息。 肾血管性高血压。