Semi-volatile PCBs: Sources, Exposures, Toxicities

半挥发性多氯联苯：来源、暴露、毒性

• 批准号: 7406731
• 负责人: LARRY W ROBERTSON
• 金额: $ 297.45万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-12 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7406731
• 关键词: Semi; volatile; PCBs; Sources; Exposures

DESCRIPTION (provided by applicant) The Superfund basic research program at the University of Iowa (ISBRP) is a joint endeavor involving basic, mechanistic and applied projects in biomedical and non-biomedical research areas. The program's overall theme is the consequences of atmospheric sources and exposures to semi-volatile Polychlorinated Biphenyls (PCBs), and it deals with volatilization, transport and exposure of lower halogenated PCBs, especially those PCBs that are associated with contaminated waters, former industrial sites, other atmospheric sources, and the consequences of exposure to them. We plan to identify routes of exposure with an eye to preventing or limiting exposure and ameliorating the effects. The ISBRP brings together 15 scientists, representing 5 departments in 4 colleges. Working together, they will measure sources, transport and environmental exposure of PCBs (project #4 and #6); their distribution, metabolism and toxicity in animals and humans (project #1, #2 and #3); and novel methods of phytoremediation (project #5). Studies include a community-based participatory research project-an assessment of exposures to citizens who live or work in the vicinity of sources of lower chlorinated PCBs in the Chicago Metropolitan area. We enjoy the cooperation of citizen groups in Chicago, where many ethnic-minority citizens are living below the poverty line near deindustrialized sites. Our research projects and overall efficiency are supported by seven cores- Administration, Synthesis, Analytical, Inhalation Toxicology, Training, Research Translation and Community Outreach -through which program and project administrators will oversee coordination, information transfer, design and analysis of experiments, and assessment of research. The assessment process culminates in an annual meeting of our 8-member External Advisory Committee. The Synthesis Core will synthesize all compounds/mixtures to be studied while the Analytical Core provides critical compositional information from metabolism to movement. Community Outreach and Research Translation Cores will transmit research findings to a variety of stakeholders and involve those stakeholders in research activities. A Training Core and the research projects provide for the training of more than 20 students and postdoctoral scholars. Overall this multidisciplinary program brings abroad range of experience and expertise to bear on problems associated with Superfund chemicals that are critical to the Midwest and the nation.

描述（由申请人提供） 爱荷华大学超级基金基础研究项目（ISBRP）是一项共同努力，涉及生物医学和非生物医学研究领域的基础、机械和应用项目。该计划的总体主题是大气来源和半挥发性多氯联苯 (PCB) 暴露的后果，涉及低卤化 PCB 的挥发、运输和暴露，特别是那些与受污染的水体、前工业场所、其他大气源，以及暴露于它们的后果。我们计划确定暴露途径，着眼于预防或限制暴露并改善影响。 ISBRP 汇集了 15 名科学家，代表 4 个学院的 5 个系。他们将共同测量多氯联苯的来源、运输和环境暴露（项目#4和#6）；它们在动物和人类中的分布、代谢和毒性（项目#1、#2和#3）；和植物修复的新方法（项目#5）。研究包括一个以社区为基础的参与性研究项目——对芝加哥大都市区生活或工作在低氯多氯联苯来源附近的公民的接触情况进行评估。我们享受芝加哥公民团体的合作，那里的许多少数民族公民生活在非工业化地区附近的贫困线以下。我们的研究项目和整体效率由七个核心支持 - 管理、合成、分析、吸入毒理学、培训、研究转化和社区外展 - 通过这些核心，计划和项目管理员将监督协调、信息传输、实验设计和分析以及评估研究。评估过程的最终结果是我们由 8 名成员组成的外部咨询委员会召开年度会议。合成核心将合成所有要研究的化合物/混合物，而分析核心则提供从新陈代谢到运动的关键成分信息。社区外展和研究翻译核心将把研究成果传递给各种利益相关者，并让这些利益相关者参与研究活动。培训核心和研究项目为 20 多名学生和博士后学者提供培训。总体而言，这个多学科项目带来了广泛的经验和专业知识，以解决与中西部和国家至关重要的超级基金化学品相关的问题。