Predictors of HPV16 Status and Outcomes of Oropharyngeal Cancer Patients

口咽癌患者 HPV16 状态和结果的预测因子

基本信息

批准号：
8330964
负责人：
Guojun Li
金额：
$ 13.61万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-30 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8330964
关键词：
Accounting Age Anti-Inflammatory Agents Anti-inflammatory Anus Apoptosis Apoptotic Area BAK1 gene Behavior Therapy Behavioral Genetics Biological Sciences CASP8 gene Cancer Patient Cancer Research Project Case-Control Studies Cell Cycle Cell Cycle Regulation Climate Clinical DNA Discipline Disease Education Environmental Exposure Epidemiology Etiology Exhibits Funding Future Genes Genetic Polymorphism Genital system Genotype Goals Head and Neck Cancer Head and Neck Squamous Cell Carcinoma Head and neck structure Human Papillomavirus Human papillomavirus 16 IL2 gene IL4 gene IL6 gene Immune response Immunology Incidence Individual Infection Inflammation Inflammatory Institution Instruction Interdisciplinary Study Interleukin-10 Interleukin-13 K-Series Research Career Programs Knowledge Light Link MDM2 gene Malignant Neoplasms Malignant neoplasm of cervix uteri Mentors Methodology Modification Molecular Molecular Epidemiology Neoplasm Metastasis Oncogenic Oral Oropharyngeal Squamous Cell Carcinoma Outcome PTGS2 gene Pathway interactions Patient Recruitments Patients Persons Play Predisposition Prevention strategy Principal Investigator Public Health Quality of life Recurrence Research Research Personnel Research Proposals Resources Risk Role Satellite Viruses Serum Sex Behavior Squamous cell carcinoma Staging Subgroup Survival Rate TNF gene Testing Time Training Treatment outcome United States National Institutes of Health University of Texas M D Anderson Cancer Center Vaccination Variant Viral Epidemiology anticancer research base cancer prevention cancer therapy career case control cytokine education planning follow-up genetic variant high risk improved malignant oropharynx neoplasm outcome forecast peripheral blood population based prevent prognostic programs skills treatment response treatment strategy tumor virology young adult

项目摘要

DESCRIPTION (provided by applicant): My career goal is to develop active population-based cancer research programs on molecular and viral epidemiology of virus-associated cancers. This goal builds upon my previous training in several disciplines including biological sciences, but requires further training in epidemiologic methodology, virology, and immunology. At the end of this training period, I will be an established and independent researcher in cancer prevention. I have developed a comprehensive education and mentoring plan. My education plan will provide intensive instruction in the areas of epidemiology, virology, and immunology. I have chosen five mentors, two consultants and two collaborators who will supervise specific portions of my training. My research proposal will focus on identifying susceptibility markers for both HPV16 status and HPV16- associated outcome among squamous cell carcinoma of the oropharyx (SCCOP) patients. I propose a case-case comparison study capitalizing on two currently ongoing NIH-funded case-control study of head and neck cancer and HPV16 DNA in peripheral blood follow-up study of SCCOP. My research goal is to identify certain sexual behaviors and genetic polymorphisms in cell cycle control/apoptosis and inflammation/immune response pathways that could serve as predictors of risk of HPV16 status and modify HPV16-associated survival in SCCOP patients. The specific aims are: 1) To investigate if certain sexual behaviors are associated with an increased risk of HPV16* status among 300 incident SCCOP patients. The impact of a link between sexual behaviors and HPV16 status will help establish the environmental exposures associated with HPV16 in SCCOP, which has obvious public health implications especially in light of the recent approval of HPV vaccination to prevent cervical cancer; 2) To investigate if adverse genotypes in cell cycle control/apoptosis and inflammation/immune response pathways are associated with an increased risk of HPV16* status among SCCOP patients. Genetic polymorphisms involved in these pathways may play a significant role in person-to-person variability in susceptibility to HPV16 infection, having cancer prevention implications; and 3) To determine if selected common genetic variants of genes in cell cycle control/apoptosis and inflammation/immune response pathways modify clinical outcomes in patients with HPV16* SCCOP. While knowing the HPV16 status of SCCOP patients will likely become an important prognostic implication with potential influences on future treatment and prevention strategies for an improved survival and a better quality of life, understanding germline modifications of the outcomes associated with HPV16 positivity will be the next step toward the goal of more individualized, less morbid, and more successful cancer treatment.

描述（由申请人提供）：我的职业目标是制定有关病毒相关癌症分子和病毒流行病学的积极积极的癌症研究计划。这个目标是基于我以前在包括生物科学在内的几个学科的培训的基础上，但需要在流行病学方法论，病毒学和免疫学方面进行进一步的培训。在这个培训期结束时，我将成为预防癌症的既定且独立的研究人员。我制定了全面的教育和指导计划。我的教育计划将在流行病学，病毒学和免疫学领域提供密集的指导。我选择了五位导师，两名顾问和两名合作者，他们将监督我培训的特定部分。我的研究建议将集中于确定Oropharyx（SCCOP）患者鳞状细胞癌中HPV16状态和HPV16相关结果的易感性标记。我提出了一项病例案例比较研究，利用了目前正在进行的NIH资助的头颈癌和HPV16 DNA的病例对照研究，用于SCCOP的外周血随访研究。我的研究目的是在细胞周期控制/凋亡和炎症/免疫反应途径中确定某些性行为和遗传多态性，这些途径可以作为HPV16状态风险的预测指标，并修改SCCOP患者中与HPV16相关的生存率。具体目的是：1）调查300名事件SCCOP患者中某些性行为是否与HPV16*状态的风险增加有关。性行为与HPV16状态之间的联系的影响将有助于建立与SCCOP中与HPV16相关的环境暴露，这显然具有公共卫生的影响，尤其是鉴于最近批准了HPV疫苗接种以防止宫颈癌； 2）研究细胞周期控制/凋亡和炎症/免疫反应途径中的不良基因型是否与SCCOP患者中HPV16*状态的风险增加有关。这些途径中涉及的遗传多态性可能在人与人之间的变异性中起重要作用，这在对HPV16感染的敏感性中具有预防癌症的影响。 3）为确定在细胞周期控制/凋亡中选择的常见基因遗传变异和炎症/免疫反应途径是否会改变HPV16* SCCOP患者的临床结果。尽管了解SCCOP患者的HPV16状态可能会成为重要的预后意义，并潜在影响未来的治疗和预防策略，以改善生存和更好的生活质量，但了解与HPV16阳性相关的结果的生殖线修改将是下一步将是实现更多个性化的，较少个性化的，更少的MORBID，更成功的癌症治疗的目标。