Enviromental Exposures, Host Factors and Human Disease

环境暴露、宿主因素和人类疾病

基本信息

批准号：
8266299
负责人：
FRANK D. GILLILAND
金额：
$ 177.71万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8266299
关键词：
8q24 Adverse effects Affect Air Air Pollutants Air Pollution Area Asthma Atherosclerosis Basic Science Biological Biological Assay Biostatistics Core Biotechnology California Cardiovascular Diseases Cardiovascular system Characteristics Chemicals Chemistry Child Chromosomes Chronic Chronic Disease Collaborations Colorectal Cancer Communities Community Health Education Community Outreach Core Facility Databases Development Development Plans Disease Education Elements Endometrial Carcinoma Engineering Environment Environmental Exposure Environmental Hazards Environmental Health Environmental Tobacco Smoke Epigenetic Process Evolution Faculty Fostering Funding Gases Genes Genetic Genomics Goals Health Health Policy Health Sciences Human Human Genome Project Influentials Integration Host Factors Interdisciplinary Study Investigation Ionizing radiation Leadership Link Los Angeles Lung diseases Malignant Neoplasms Malignant neoplasm of prostate Measurement Methods Modeling Molecular Biology Mutation Neurology Obesity Ontology Outcome Outreach Research Oxidative Stress Pathway interactions Pesticides Physics Physiology Pilot Projects Play Policies Policy Developments Policy Maker Pollution Population Positioning Attribute Predisposition Prevention Preventive Process Productivity Proteins Public Health Public Policy Radiation Reactive Oxygen Species Recruitment Activity Research Research Design Research Methodology Research Personnel Research Support Respiratory physiology Rest Risk Role Sampling Science Scientific Advances and Accomplishments Seminal Shapes Software Tools Staging Stress Structure Sunlight Techniques Technology Testing Toxic effect Toxicokinetics Translating Translational Research Transportation Ultraviolet Rays Urban Developments Vision ambient particle base cancer risk career development climate change design empowered epigenomics evidence base exposed human population genetic variant genome wide association study genome-wide global environment health science research human disease improved innovation malignant breast neoplasm multidisciplinary nervous system disorder neurodevelopment new technology novel strategies obesity in children oxidative damage particle particle exposure pollutant programs research facility respiratory social success trafficking ultrafine particle

项目摘要

DESCRIPTION (provided by applicant) The Southern California Environmental Health Sciences Center's theme is Environmental Exposures, Host Factors and Human Disease. The Center has a multidisciplinary team of investigators from Southern California and features several interdisciplinary cornerstones: detailed exposure assessment; cutting-edge study design; and the basic sciences, including physiology, molecular biology, genetics, physics, chemistry, and engineering. The Center emphasizes environmental exposures of public health importance including air pollution, pesticides, ultraviolet and ionizing radiation, and secondhand smoke. The Center is structured to foster cutting-edge environmental health sciences (EHS) research, build research capacity, recruit and develop investigators, and promote interdisciplinary linkage between research and outreach. It is led by a team of highly accomplished investigators who have a record of collaboration and scientific productivity. Four Research Cores (Cancer, Cardio-respiratory Effects, Exposure Assessment, and Study Design) and two Facility Cores (Biostatistics and Integrative Health Sciences) are the primary structural elements. The Center also features a dynamic Community Outreach and Education Core and a robust Career Development Program. During the 14 years of support, the Center has catalyzed research that has filled critical gaps in environmental health science as well as raised new questions that need to be answered. The Center has been instrumental in recruiting new and accomplished investigators to environmental health science. It has nurtured new research ideas, stimulated greater interactions in existing and new multidisciplinary teams, and supported the development of new technologies and state-of-the-art facilities. The Center's research initiatives for the next five years are new approaches for Chemical and Biological-Based Exposure Assessment for Pollutants; Environmental Epigenomics; Environmental Contributions to Obesity; Pathway Approaches to Linking Environment, Genetics and Health; Air Pollution, Neurodevelopment and Neurological Diseases; Global Environmental Health and Climate Change; and Sunlight in Health and Disease. The Center is poised to advance research in these areas by building on its successful approaches in facilitating cutting-edge environmental health science research.

描述（由申请人提供）南加州环境健康科学中心的主题是环境暴露、宿主因素和人类疾病。该中心拥有一支由来自南加州的多学科研究人员组成的团队，并具有几个跨学科的基石：详细的暴露评估；前沿的研究设计；以及基础科学，包括生理学、分子生物学、遗传学、物理学、化学和工程学。该中心强调对公共卫生具有重要意义的环境暴露，包括空气污染、农药、紫外线和电离辐射以及二手烟。该中心的结构旨在促进尖端环境健康科学（EHS）研究、建设研究能力、招募和培养研究人员以及促进研究和推广之间的跨学科联系。它由一支经验丰富的研究人员团队领导，他们拥有合作记录和科学生产力。四个研究核心（癌症、心肺效应、暴露评估和研究设计）和两个设施核心（生物统计学和综合健康科学）是主要结构要素。该中心还拥有充满活力的社区外展和教育核心以及强大的职业发展计划。在 14 年的支持中，该中心促进了多项研究，填补了环境健康科学领域的关键空白，并提出了需要回答的新问题。该中心在招募新的和有成就的环境健康科学研究人员方面发挥了重要作用。它培育了新的研究理念，激发了现有和新的多学科团队之间更大的互动，并支持新技术和最先进设施的开发。该中心未来五年的研究举措是基于化学和生物的污染物暴露评估的新方法；环境表观基因组学；环境对肥胖的影响；连接环境、遗传学和健康的途径方法；空气污染、神经发育和神经系统疾病；全球环境健康和气候变化；以及阳光对健康和疾病的影响。该中心准备通过其促进尖端环境健康科学研究的成功方法来推进这些领域的研究。