QUANTITATION OF DMSO BY GC/EI/MS IN MAMMALIAN CNS

通过 GC/EI/MS 对哺乳动物中枢神经系统中的 DMSO 进行定量

• 批准号: 7721555
• 负责人: NURI B FARBER
• 金额: $ 0.31万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721555
• 关键词: Brain region; Computer Retrieval of Information on Scientific Projects Database; Dimethyl Sulfoxide; Dose; Funding; Grant; Human; Infant; Institution; Methanol; Neurons; Polyethylene Glycols; Propylene Glycols; Propylene glycol; Range; Research; Research Personnel; Resources; Solvents; Source; United States National Institutes of Health; brain tissue; killings

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project Summary: A wide range of solvents kill neurons in the developing mammalian CNS. Solvents include DMSO, propylene glycol, polyethylene glycol(PEG), methanol and nonanol. After characterizing the specific regions of the brain and the doses needed to produce the damage, concentrations of the agents in brain tissue need to be determined in order in order to help determine the potential significance to human infants. Identification and quantitation will be carried out by GC/EI/MS.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 项目摘要：多种溶剂会杀死发育中的哺乳动物中枢神经系统中的神经元。溶剂包括DMSO、丙二醇、聚乙二醇(PEG)、甲醇和壬醇。在描述了大脑的特定区域和产生损伤所需的剂量后，需要确定脑组织中药物的浓度，以帮助确定对人类婴儿的潜在意义。鉴定和定量将通过GC/EI/MS 进行。