ADDRESSING EMERGING INFECTIOUS DISEASES IN THE REPUBLIC OF INDIA: INFLUENZA DISEA

应对印度共和国新出现的传染病：流感疾病

• 批准号: 8325850
• 负责人: AKILESH C MISHRA
• 金额: $ 2.5万
• 依托单位: NATIONAL INSTITUTE OF VIROLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8325850
• 关键词: ADDRESSING; EMERGING; INFECTIOUS; DISEASES; REPUBLIC

DESCRIPTION (provided by applicant): The burden of disease related to influenza virus infection in India is not well defined but likely to be substantial given that India accounts for 20% of global childhood deaths due to acute respiratory infections. To address this issue a population-based longitudinal burden of disease study will be implemented at two study sites in rural India. Vadu is the proposed southern Indian study site located 40 Km northeast of Pune and Ballabhgarh is the proposed northern Indian study site located 40 Km south of Delhi. Each of these sites have ongoing community and demographic surveillance systems that make them optimal locations for study implementation. The primary aim of this study is to determine the incidence of severe hospitalized and medically attended non-hospitalized influenza in each of these communities. Secondary aims include describing the spectrum and seasonality of clinical illness related to seasonal influenza, identifying risk factors for severe seasonal influenza, and describing health care utilization and the burden of respiratory disease that should seek medical care but does not, in these communities. After approvals have been obtained and the study is initiated, implementation and analysis is expected to take approximately three years.

描述（由申请人提供）：印度与流感病毒感染有关的疾病负担不是很好的定义，但由于印度占由于急性呼吸道感染而占全球儿童死亡的20％。为了解决这个问题，将在印度农村的两个研究地点实施基于人群的纵向负担。瓦杜（Vadu）是拟议的南部印度研究地点，位于浦那东北40公里处，巴拉比（Ballabhgarh）是拟议的北部印度研究地点，位于德里以南40公里处。这些站点中的每个站点都有正在进行的社区和人口监视系统，使其成为研究实施的最佳位置。这项研究的主要目的是确定这些社区中每个社区中严重住院和医学上没有住院的流感的发生率。次要目的包括描述与季节性流感相关的临床疾病的频谱和季节性，确定了严重的季节性流感危险因素，并描述了医疗保健利用以及在这些社区中应寻求医疗服务但不应寻求医疗服务的呼吸道疾病负担。获得批准并开始研究后，实施和分析预计将花费大约三年。

项目成果

Use of TaqMan Array card for the detection of respiratory viral pathogens in children under 5 years old hospitalised with acute medical illness in Ballabgarh, Haryana, India.

使用 TaqMan 阵列卡检测印度哈里亚纳邦 Ballabgarh 因急性疾病住院的 5 岁以下儿童的呼吸道病毒病原体。

• DOI: 10.4103/ijmm.ijmm_18_146
• 发表时间: 2019
• 期刊: Indian journal of medical microbiology
• 影响因子: 1.6
• 作者: Gaur,Bharti;Saha,Siddhartha;Iuliano,ADanielle;Rai,SanjayK;Krishnan,Anand;Jain,Seema;Whitaker,Brett;Winchell,Jonas;Lal,RenuB;Broor,Shobha
• 通讯作者: Broor,Shobha

Evaluation of case definitions for estimation of respiratory syncytial virus associated hospitalizations among children in a rural community of northern India.

• DOI: 10.7189/jogh.05.020419
• 发表时间: 2015-12
• 期刊: Journal of global health
• 影响因子: 7.2
• 作者: Saha S;Pandey BG;Choudekar A;Krishnan A;Gerber SI;Rai SK;Singh P;Chadha M;Lal RB;Broor S
• 通讯作者: Broor S

Estimation of community-level influenza-associated illness in a low resource rural setting in India.

• DOI: 10.1371/journal.pone.0196495
• 发表时间: 2018
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Saha S;Gupta V;Dawood FS;Broor S;Lafond KE;Chadha MS;Rai SK;Krishnan A
• 通讯作者: Krishnan A

Validity of clinical case definitions for influenza surveillance among hospitalized patients: results from a rural community in North India.

• DOI: 10.1111/j.1750-2659.2012.00401.x
• 发表时间: 2013-05
• 期刊: Influenza and other respiratory viruses
• 影响因子: 4.4
• 作者: Gupta V;Dawood FS;Rai SK;Broor S;Wigh R;Mishra AC;Lafond K;Mott JA;Widdowson MA;Lal RB;Krishnan A
• 通讯作者: Krishnan A