NICHD Maternal Fetal Medicine Units Network

NICHD 母胎医学单位网络

• 批准号: 8251945
• 负责人: Geeta K. Swamy
• 金额: $ 30.91万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-07 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8251945
• 关键词: Academic Medical Centers; Anesthesia procedures; Asthma; Award; Basic Science; Biomedical Research; Birth; Blindness; Cardiology; Cardiovascular Diseases; Caring; Cerebral Palsy; Child; Chronic lung disease; Clinical; Clinical Nurse Specialists; Clinical Research; Clinical Sciences; Clinical Trials; Commit; Communicable Diseases; Complex; Data; Decision Analysis; Diabetes Mellitus; Discipline of obstetrics; Disease; Enrollment; Epidemiologic Studies; Faculty; Family; Fetal Growth Retardation; Genetic; Gestational Diabetes; Gynecologist; Gynecology; Health; Health system; Hematology; Hemostatic function; Hospitals; Hypertension; Hypertension induced by pregnancy; Immunization; Infant; Infant Mortality; Institute of Medicine (U.S.); Institutes; Institution; Intervention; Learning; Life; Life Expectancy; Low Birth Weight Infant; Medical; Midwife; Modeling; Molecular Biology; Monitor; Mothers; Multicenter Studies; National Institute of Child Health and Human Development; Neonatal; Neonatology; North Carolina; Participant; Pathology; Patients; Pediatrics; Perinatal; Pharmacology; Pharmacy facility; Plague; Population Sizes; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Premature Infant; Premature Rupture Fetal Membranes; Prenatal Diagnosis; Prenatal care; Principal Investigator; Problem behavior; Protocols documentation; Recruitment Activity; Reproduction; Research; Research Design; Research Infrastructure; Research Subjects; Resources; Risk; Safety; Science; Services; Site; Survivors; Technical Expertise; Thrombosis; Time; Translational Research; Treatment Efficacy; United States National Institutes of Health; Universities; Woman; Work; burden of illness; care delivery; clinical research site; cost; cost effectiveness; diabetes risk; disability; experience; fetal; fetal medicine; follow-up; hearing impairment; high risk; improved; novel; perinatal health; premature; preterm premature rupture of membranes; prevent; public health relevance; racial difference; randomized trial; response; success; translational medicine

DESCRIPTION (provided by applicant): Caring for and improving the lives of mothers and families, Duke Maternal-Fetal Medicine (MFM) is an academically oriented group with the requirements to participate in the Maternal-Fetal Medicine Units Network (MFMU). We are well-suited to be an MFMU site given our research infrastructure, successful track record in basic and translational research, and patient volume. With 4 primary research faculty and 10 research staff, Duke MFM has a highly functional research team with over 10 years of experience in single and multi-center studies. Content expertise includes prematurity, premature rupture of membranes, fetal growth restriction, racial disparities, maternal immunization, and maternal medical conditions - particularly thrombosis and hemostasis. Technical expertise includes study design, recruitment and retention, molecular biology, data safety monitoring, coordinating and analysis, and decision/cost-effectiveness modeling. With 14 faculty, 6 fellows, 9 midwives, and 8 nurse clinicians, Duke MFM provides full service high-risk prenatal care and delivery, prenatal diagnosis, and consultative services for the Duke University Health System (DUHS). For the MFMU, we propose to recruit participants from -5,500 annual births across two DUHS institutions in Durham, North Carolina - Duke University Medical Center (-3,300) and Durham Regional Hospital (DRH) (-2,200). High risk conditions like hypertension, diabetes, asthma, multi-fetal gestation, prematurity, and low birthweight occur among half of all births across DUHS. Duke MFM has a productive relationship with Neonatology, providing continued expertise and support for their participation in the Neonatal Research Network. Further, we have active partnerships across the Duke University campus including pediatrics, anesthesia, infectious diseases, cardiology, hematology, pathology, genetics, pharmacology, epidemiology, research pharmacies and the Duke Translational Medicine Institute (NIH Clinical & Translational Science Award), which can aid our success in the MFMU. Duke MFM is committed to work cooperatively with NICHD and the MFMU and has the expertise, resources, and institutional support to be a productive and successful site involved in multicenter collaborative research involving perinatal health. PUBLIC HEALTH RELEVANCE: Intervention strategies for maternal-fetal conditions such as prematurity, low birth weight, and preeclampsia remain controversial. Observational and randomized trials conducted in an academic multi-center network like the MFMU allows for adequately-sized populations of socio-demographically diverse women in a timely manner and the potential for rapid dissemination of efficacious interventions to practicing ObGyn.

描述（由申请人提供）：照顾和改善母亲和家庭的生活，杜克大学母亲医学（MFM）是一个以学术为导向的群体，要求参与母亲 - 菲尔特医学单位网络（MFMU）。鉴于我们的研究基础设施，基本和转化研究中的成功记录以及患者的数量，我们非常适合成为MFMU站点。 MFM拥有4位主要研究教师和10名研究人员，拥有一支功能齐全的研究团队，在单一和多中心研究方面拥有超过10年的经验。内容专业知识包括早产，膜过早破裂，胎儿生长限制，种族差异，孕产妇免疫和孕产妇医疗状况，尤其是血栓形成和止血。技术专长包括研究设计，招聘和保留，分子生物学，数据安全监测，协调和分析以及决策/成本效益建模。 Duke MFM拥有14名教职员工，6名助产士和8位护士临床医生，为杜克大学卫生系统（DUHS）提供全方位服务的高风险产前护理和交付，产前诊断和咨询服务。对于MFMU，我们建议在北卡罗来纳州达勒姆的两个DUHS机构 - 杜克大学医学中心（-3,300）和达勒姆地区医院（DRH）（-2,200）的两个DUHS机构中招募参与者。高风险状况如高血压，糖尿病，哮喘，多野性妊娠​​，早产和低出生体重，在所有DUH的一半出生中发生。公爵MFM与新生儿学有富有成效的关系，为他们参与新生儿研究网络提供了持续的专业知识和支持。此外，我们在杜克大学校园内建立了积极的伙伴关系，包括儿科，麻醉，传染病，心脏病学，血液学，病理学，病理学，遗传学，药理学，药理学，流行病学，研究药房和杜克大学翻译医学研究所（NIH临床和翻译科学奖），这有助于我们在MFMU中的成功。 MFM杜克大学致力于与NICHD和MFMU合作，并拥有专业知识，资源和机构支持，成为涉及围产期健康的多中心协作研究的富有成效和成功的网站。 公共卫生相关性：诸如早产，低出生体重和先兆子痫等产妇条件的干预策略仍然存在争议。像MFMU这样的学术多中心网络中进行的观察性和随机试验允许及时及时地提供大小的社会人口统计学上多样化女性的人群，并有可能快速传播有效的干预措施以实践OBGYN。