Mood, Substance Use and Suicidality in Bipolar Adolescents: A Prospective Study

双相情感障碍青少年的情绪、药物使用和自杀倾向：一项前瞻性研究

基本信息

批准号：
8332759
负责人：
TINA R GOLDSTEIN
金额：
$ 3.79万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-15 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8332759
关键词：
Acute Adolescent Affective Alcohol or Other Drugs use American Bipolar Disorder Cause of Death Cereals Clinical Comorbidity Data Differential Diagnosis Diffuse Disease Distal Evaluation Exhibits Feeling suicidal Foundations Funding Grant Hour Individual Interview Lead Longitudinal Studies Maps Measures Mental Depression Mental disorders Methods Mood Disorders Moods Morbidity - disease rate Nature Onset of illness Parents Population Preclinical Drug Evaluation Prevention Preventive Preventive Intervention Prospective Studies Public Health Reporting Research Research Personnel Retrospective Studies Risk Risk Factors Sampling Sleep Sleep disturbances Staging Substance Use Disorder Suicide Suicide attempt Suicide prevention Time Toxicology Urine Youth accomplished suicide binge drinking design disturbance in affect experience follow-up high risk ideation improved mortality negative mood prospective research study suicidal adolescent suicidal behavior suicidal risk suicide attempter

项目摘要

DESCRIPTION (provided by applicant): Youth suicide constitutes a major public health problem, ranking as the second leading cause of death for youth worldwide. Of all psychiatric disorders in youth, bipolar disorder imparts the greatest risk for suicide, followed by a substance use disorder. Mood disorder and substance use disorders commonly co-occur, and the combination increase the risk for completed suicide in adolescents exponentially over either disorder alone. Unfortunately, effective suicide prevention efforts, particularly for the ultra-high-risk population of youth with mood disorder and substance use, remain limited. This void in the treatment research may be understood by findings that a multitude of factors from a variety of domains contribute to suicidal risk; such factors remain too diffuse and multiply determined to be considered optimal targets for preventive interventions. Experts in the field have thus called for prospective, longitudinal studies in high-risk samples to systematically investigate specific mechanisms of suicide risk in adolescents. The American Association of Suicidology has specifically identified a need for research on proximal, dynamic and modifiable factors for substance use-to inform targeted preventive approaches for high-risk populations.

描述（由申请人提供）：青年自杀构成了一个重大的公共卫生问题，是全球青年的第二大死亡原因。在青年中的所有精神疾病中，躁郁症赋予自杀风险最大，其次是药物使用障碍。情绪障碍和物质使用障碍通常是同时发生的，并且组合增加了仅在任何一种疾病上，青少年的完成自杀的风险。不幸的是，有效的自杀预防工作，特别是对于具有情绪障碍和吸毒的超高风险的青年人口，仍然有限。可以通过发现各种领域的多种因素导致自杀风险的发现可以理解治疗研究中的这种空隙。这些因素仍然太分散了，并确定为预防干预措施的最佳目标。因此，该领域的专家呼吁在高风险样本中进行前瞻性的纵向研究，以系统地研究青少年自杀风险的特定机制。美国自杀学协会特别确定了对近端，动态和可修改因素进行研究的需求，以便为高危人群提供有针对性的预防方法。