MODULATION AND NEUROPLASTIC BEHAVIOR IN INHERITENCE FORM OF HYPERTENSION

遗传性高血压的调节和神经塑性行为

• 批准号: 8270348
• 负责人: AZEEZ A AILERU
• 金额: $ 20.42万
• 依托单位: WINSTON-SALEM STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8270348
• 关键词: Action Potentials; Affect; African American; Animal Model; Animals; Antihypertensive Agents; Autonomic ganglion; Behavior; Biochemical; Biological; Blood Pressure; Cells; Cerebrovascular Circulation; Cervical; Chest; Data; Disease; Electric Stimulation; Event; Exhibits; Genetic; Genetic Models; Genetic Predisposition to Disease; Goals; Human; Hypertension; Ion Channel; Knock-out; Knowledge; Lead; Maintenance; Modeling; Molecular; Monitor; Morbidity - disease rate; Nerve; Neuraxis; Neurons; Neurostimulation procedures of spinal cord tissue; Organism; Patch-Clamp Techniques; Pattern; Perception; Peripheral; Physiological; Physiology; Population; Preventive; Preventive Intervention; Property; Rattus; Research; Signal Pathway; Signal Transduction; Sympathetic Ganglia; Sympathetic Nervous System; Synaptic Transmission; Synaptic plasticity; System; Techniques; Testing; Therapeutic; Therapeutic Intervention; Transgenic Organisms; United States; Work; base; caucasian American; expectation; health disparity; hypertension control; improved; innovation; minority health; mortality; novel; postsynaptic; presynaptic; prevent; receptor; response; transmission process

Hypertension affects over 50 million people in the United States and is disturbingly higher in African Americans than in white Americans. Evidence suggests that a genetic predisposition to hypertension may underlie this health disparity. Studies suggest that hypertensive humans and animal models of hypertension exhibit increased peripheral sympathetic nervous system activity (SNA) but the knowledge of the events that lead to elevated SNA and its significance in the genesis and maintenance of elevated blood pressure is rudimentary.

美国有超过 5000 万人患有高血压，而非洲的高血压患者比例则高得令人不安 美国人多于美国白人。有证据表明，高血压的遗传倾向可能 造成这种健康差异的原因。研究表明高血压人类和高血压动物模型 表现出周围交感神经系统活动（SNA）增加，但对事件的了解 导致 SNA 升高，其在血压升高的发生和维持中的意义是 简陋的。