CELLULAR RESPONSE TO ALASKAN SMOKELESS TOBACCO - IQMIK AND BLUEBERRY EXTRACT

阿拉斯加无烟烟草的细胞反应 - IQMIK 和蓝莓提取物

• 批准号: 8359596
• 负责人: CINDY M KNALL
• 金额: $ 5.22万
• 依托单位: UNIVERSITY OF ALASKA FAIRBANKS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359596
• 关键词: Address; Alaska; Alaska Native; Blueberries; Clinical; DNA Adducts; Development; Disease; Epithelial; Epithelial Cells; Exposure to; Funding; Goals; Grant; Health; Inflammation Mediators; Intervention; National Center for Research Resources; Oral; Outcome; Pharmacologic Substance; Principal Investigator; Regulation; Research; Research Infrastructure; Resources; Smokeless Tobacco; Source; Testing; Therapeutic; Therapeutic Intervention; Tobacco; Tobacco Use Cessation; United States National Institutes of Health; base; cost; environmental agent; in vivo Model; iq' mik; response; tobacco exposure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Our long range goal is to define the mechanisms responsible for tobacco induced alterations in epithelial cells to inform the development of culturally relevant tobacco cessation interventions and clinical therapeutics to address health outcomes of tobacco users. The objective of this proposal is to define the alterations in oral epithelial cells resulting from exposure to the smokeless tobacco product iqmik and to define the efficacy of the Alaska bog blueberry as a nutriceutical intervention. We will achieve this goal by testing the central hypothesis that iqmik increases the levels of inflammatory mediators and DNA adducts in oral epithelial cells and that these changes can be ameliorated by blueberry treatment. At the completion of this project, we expect to understand the changes in oral epithelial cells that occur with iqmik exposure which will allow the mechanisms controlling these alterations to be defined. Consequently, the results will identify potential targets for therapeutic intervention in the regulation of oral epithelial function during smokeless tobacco exposure, as well as provide the basis for in vivo modeling of health outcomes and pharmaceutical interventions.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 我们的长期目标是确定烟草引起上皮细胞改变的机制，为制定与文化相关的戒烟干预措施和临床治疗方法提供信息，以解决烟草使用者的健康结果。该提案的目的是确定暴露于无烟烟草产品 iqmik 引起的口腔上皮细胞的变化，并确定阿拉斯加沼泽蓝莓作为营养干预措施的功效。我们将通过测试中心假设来实现这一目标，即 iqmik 增加口腔上皮细胞中炎症介质和 DNA 加合物的水平，并且蓝莓可以改善这些变化 治疗。该项目完成后，我们希望了解 iqmik 暴露引起的口腔上皮细胞的变化，这将有助于确定控制这些变化的机制。因此，研究结果将确定无烟烟草暴露期间口腔上皮功能调节的治疗干预的潜在目标，并为健康结果的体内建模和药物干预提供基础。