STRUCTURE ACTIVITY RELATIONSHIPS OF TRPM7 ION CHANNEL INHIBITORS

TRPM7离子通道抑制剂的结构活性关系

• 批准号: 8360710
• 负责人: GIDEON O BERGER
• 金额: $ 7.46万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360710
• 关键词: Biological Assay; Biological Factors; Collection; Contracts; Education; Educational process of instructing; Equilibrium; Equipment and Supplies; Faculty; Funding; Grant; Hawaii; Ion Channel; Laboratories; National Center for Research Resources; Policies; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Role; Source; Structure-Activity Relationship; Techniques; Time; Training; United States National Institutes of Health; Universities; analog; career; coral; cost; inhibitor/antagonist; instrumentation; skills

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Due to my dual roles as the leader of the Hawaii Pacific University Shared Instrumentation INBRE Core and that as a junior investigator, I have had to balance two sets of responsibilities. For context, it is first important to note that due to issues with the sub-contract, HPU did not receive funds until late December 2010. Unfortunately, the university presently has no organized mechanism for advanced funding and thus, to some degree, our start was delayed. However, with construction of a new on-campus BL2 bioassay lab complete and assays to begin this week, I will be able to allocate much more of my time into my waixenicin A analogue project. Because HPU has no consistent policy in place to provide new faculty hires with "start-up" funds the INBRE II funding has been invaluable in supplying me with the necessary equipment and supplies to start my independent research career. Thus, a significant amount of time has also been spent researching various resources of materials and supplies. Three young researchers have recently been brought on board to the project and their training has begun. In this training endeavor, I have also begun to produce a collection of training videos that teach laboratory skills and techniques specific to natural product synthesis. We are also collecting modest quantities of natural Waixencin A for derivatization and thus one of the very first tasks was to initiate efforts towards the collection of its source, soft coral Sarcothelia edmondsoni, as well as the subsequent purification of waixenicin A.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 由于我作为夏威夷太平洋大学的领导者的双重角色共享了indermation Inbre Core，并且作为初级调查员，我不得不平衡两组责任。 在上下文中，首先要注意，由于分包合同的问题，HPU直到2010年12月下旬才收到资金。不幸的是，该大学目前没有有组织的高级资金机制，因此在某种程度上，我们的起点被推迟了。 但是，通过建造新的校园BL2生物测定实验室的完整，并开始了本周的测定，我将能够将更多的时间分配到Waixenicin一个模拟项目中。 由于HPU没有一致的政策，可以为新教师提供“启动”资金，因此Inbre II资金对于为我提供必要的设备和供应来开始我的独立研究职业非常宝贵。 因此，还花费了大量时间来研究各种材料和供应资源。 最近，三名年轻研究人员被带入该项目，他们的培训已经开始。 在这项培训努力中，我还开始制作一系列培训视频，以教授特定于自然产品合成的实验室技能和技术。 我们还正在收集适度的天然怀克辛A用于衍生化，因此，最初的任务之一是为收集其来源的软珊瑚Sarcothelia Edmondsoni以及随后的Waixeninicin A发起努力。