Core Center for Musculoskeletal Biology and Medicine

肌肉骨骼生物学和医学核心中心

• 批准号: 8044802
• 负责人: LINDA J SANDELL
• 金额: $ 59.42万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-11 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8044802
• 关键词: Core; Center; Musculoskeletal; Biology; Medicine

Washington University has a long record of excellence in musculoskeletal research and clinical care. Historically the base for the research efforts have been individual laboratories in the Departments of Medicine, Orthopaedic Surgery and Pathology. In recent years, ad hoc collaborations have developed between these groups and non-musculoskeletal investigators in Departments of Anatomy & Neurobiology, Biomedical Engineering, Cell Biology, Developmental Biology, Genetics and Pediatrics, thereby significantly expanding our biological skill set and vision. However, we have lacked a central mechanism to leverage these new collaborations efficiently into new research discoveries. With this broad, diverse research base, we propose to create the Washington University Core Center for Musculoskeletal Biology and Medicine (CCMBM). The CCMBM Research Base has 48 members who have over 21 million dollars of annual research support (direct costs). Seventeen of the members have NIAMS funding (21 research grants). The primary goals of the Center are to enhance the productivity of established musculoskeletal scientists, to support young investigators in our field and to facilitate collaboration between established skeletal scientists and those bringing non-traditional questions and strategies to our discipline. The major programmatic focus of the CCMBM will be to support and expedite the creation and analysis of animal models of relevance to musculoskeletal biology and disease. Three Research Cores are proposed: Musculoskeletal Structure and Strength (Core B), In Situ Molecular Analysis (Core C), and Mouse Genetic Models (Core D). Our basic and translational research efforts will be directed toward an understanding of musculoskeletal biology at the molecular, cellular and tissue levels with the goal that such studies will directly impact our understanding of the pathophysiology of osteoporosis, osteoarthritis, muscular dystrophy, osteochondrodysplasias as well as regeneration of bone, cartilage, tendon and muscle. Through the Administrative Core (Core A), the CCMBM will sponsor enrichment activities to promote the exchange of information, ideas and reagents between CCMBM members, and to engage non-members who are doing meritorious research of interest to the CCMBM membership. We will also implement a Pilot & Feasibility Grant Program to provide funding support to young investigators in our field as well as to established, non-musculoskeletal investigators who propose to apply their outside expertise to a problem in musculoskeletal biology or medicine.

华盛顿大学在肌肉骨骼研究和临床护理方面拥有悠久的卓越记录。从历史上看，研究工作的基础是医学、骨科和病理学系的各个实验室。近年来，这些小组与解剖学和神经生物学、生物医学工程、细胞生物学、发育生物学、遗传学和儿科等系的非肌肉骨骼研究人员之间发展了临时合作，从而显着扩展了我们的生物学技能和视野。然而，我们缺乏一个中央机制来有效地将这些新的合作转化为新的研究发现。凭借这一广泛、多样化的研究基础，我们建议创建华盛顿大学肌肉骨骼生物学和医学核心中心 (CCMBM)。 CCMBM研究基地有48个成员，每年的研究支持（直接费用）超过2100万美元。其中 17 名成员获得 NIAMS 资助（21 项研究资助）。该中心的主要目标是提高成熟的肌肉骨骼科学家的生产力，支持我们领域的年轻研究人员，并促进成熟的骨骼科学家与那些为我们学科带来非传统问题和策略的科学家之间的合作。 CCMBM 的主要计划重点将是支持和加速与肌肉骨骼生物学和疾病相关的动物模型的创建和分析。提出了三个研究核心：肌肉骨骼结构和强度（核心 B）、原位分子分析（核心 C）和小鼠遗传模型（核心 D）。我们的基础和转化研究工作将致力于在分子、细胞和组织水平上了解肌肉骨骼生物学，目标是这些研究将直接影响我们对骨质疏松症、骨关节炎、肌肉营养不良、骨软骨发育不良以及再生的病理生理学的理解骨、软骨、肌腱和肌肉。通过行政核心（核心 A），CCMBM 将主办丰富活动，以促进 CCMBM 成员之间的信息、思想和试剂交流，并吸引正在进行 CCMBM 成员感兴趣的有价值研究的非成员。我们还将实施一项试点和可行性资助计划，为我们领域的年轻研究人员以及打算将其外部专业知识应用于肌肉骨骼生物学或医学问题的成熟非肌肉骨骼研究人员提供资金支持。