Administrative Core

行政核心

• 批准号: 10403253
• 负责人: LOUIS J SOSLOWSKY
• 金额: $ 24.18万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10403253
• 关键词: Address; Advisory Committees; Animal Model; Animals; Area; Back; Beds; Biological Assay; Cell Nucleus; Cells; Center for Translational Science Activities; Clinical; Committee Membership; Communication; Communities; Data; Development; Ensure; Etiology; Evaluation; Fostering; Frequencies; Funding; Future; Grant; Leadership; Modality; Modeling; Monitor; Musculoskeletal Diseases; Pain; Pathogenesis; Pennsylvania; Physiological Processes; Positioning Attribute; Prevalence; Productivity; Reporting; Research; Research Activity; Research Project Grants; Resources; Role; Scientist; Series; Societies; Structure; Technology; Tendinopathy; Tendon structure; Testing; Tissues; Translations; Universities; cost; disability; effective therapy; experience; human subject; in vivo; innovation; interest; multidisciplinary; new technology; older patient; programs; translational impact

The Achilles Tendinopathy Center of Research Translation (AT-CORT) at the University of Pennsylvania will foster fundamental discovery research to guide translation, as well as employ and develop translational resources, models and technologies, to address the highly significant research and unmet clinical challenge of Achilles tendinopathy. Despite the high frequency and increasing prevalence of tendinopathy to young and old patients alike, the significant pain and disability, as well as the associated high cost to society, evaluation and development of effective treatment modalities is hindered by the lack of fundamental guiding data on the mechanobiology of tendon etiology and pathogenesis. At the University of Pennsylvania, we are uniquely positioned with a critical mass of multidisciplinary scientists and clinicians with strong interest and expertise in these and related areas. The Center’s efforts will span from the nucleus, to the cell, to the tissue, to in vivo animal models and to living human subjects in a coordinated “back-and-forth” manner across scales to guide innovative approaches to Achilles tendinopathy. The Center’s research will discover fundamental physiologic processes to guide translation. It will also as serve as a test bed for defining the role, as well as the scientific and translational rigor, of a repetitive use Achilles tendinopathy animal model through implementation of an exciting series of in vivo longitudinal assays to be conducted in parallel in both animal and human subjects. The Specific Aims of this Administrative Core are to: Aim 1: Provide leadership for Center components and activities and advise the Center Director regarding current or potential future activities of the Center; Aim 2: Manage, evaluate and monitor the Center components and activities; Aim 3: Communicate the Center’s activities to the scientific, clinical, and lay communities; Aim 4: Administer the Pilot and Feasibility Grant Program and its associated funding and reporting; and Aim 5: Implement an Enrichment Program. The Core and Research Projects have been carefully developed in concert to bridge the fundamental and applied while being highly interactive. With regular guidance from our Committee structure (External Advisory, Executive, Communication, Enrichment), we will adapt our efforts to address our translational theme in the most efficient, effective, and productive manner possible. Our Pilot and Feasibility Grant program will foster new and innovative project directions consistent with our theme as well as support development of novel technologies to bring to our projects and for translation of our efforts. Our approach will serve as a critical paradigm for other tendon and indeed other musculoskeletal disorders and we will build on these efforts. A well organized and well-structured Administrative Core is absolutely essential to accomplish the Aims of the Center’s highly interdisciplinary and interactive Research Projects and Core, and to maximize research activity, efficiency, productivity, communication, and ultimate impactful translation of our efforts to the scientific and lay community.

宾夕法尼亚大学研究翻译中心（AT-CORT）的跟腱疾病中心将 促进基本发现研究，以指导翻译，以及员工并发展翻译 资源，模型和技术，以应对高度重要的研究和未满足的临床挑战 跟腱病。尽管肌腱病的频率很高，而且年轻人的患病率也增加 患者，明显的疼痛和残疾以及相关的社会，评估和相关的高昂成本 由于缺乏有关该数据的基本指导数据的阻碍，有效治疗方式的发展受到了阻碍。 肌腱病因和发病机理的机械生物学。在宾夕法尼亚大学，我们是独特的 位于具有浓厚兴趣和专业知识的众多跨学科科学家和临床医生的位置 这些及相关领域。该中心的努力将从细胞核，细胞到组织，到体内 动物模型和以协调的“来回”方式生活的人类受试者，以指导 致命肌腱疗法的创新方法。该中心的研究将发现基本的生理学 指导翻译的过程。它也将用作定义角色以及科学的测试床 并通过实施一个重复使用跟腱的重复使用致命的肌腱病模型 令人兴奋的一系列体内纵向测定法在动物和人类受试者中并行进行。 该行政核心的具体目的是：目标1：为中心组件提供领导 活动并就中心的当前或潜在的未来活动向中心主任提供建议；目标2： 管理，评估和监视中心组件和活动；目标3：交流中心的 科学，临床和外行社区的活动；目标4：管理飞行员和可行性赠款 计划及其相关资金和报告；和目标5：实施一个丰富计划。核心 研究项目已经经过精心开发，以弥合基本和应用 高度互动。在我们委员会结构的定期指导下（外部咨询，执行官， 沟通，丰富），我们将根据最有效，最有效， 有效和产品方式。我们的飞行员和可行性赠款计划将培养新的，并且 创新的项目指示与我们的主题一致，并支持开发新技术 带给我们的项目并翻译我们的努力。我们的方法将成为其他人的关键范式 肌腱及其他肌肉骨骼疾病，我们将以这些努力为基础。一个井井有条的 结构良好的行政核心对于完成该中心的目标绝对至关重要 跨学科和互动研究项目和核心，以最大化研究活动，效率， 生产力，沟通和最终有影响力的翻译，我们对科学的努力和局面 社区。