San Diego Clinical and Translational Research Institute

圣地亚哥临床和转化研究所

• 批准号: 8317867
• 负责人: GARY S FIRESTEIN
• 金额: $ 29.21万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8317867
• 关键词: Academia; Adopted; Adoption; Area; Award; Basic Science; Bioinformatics; Biological; Biological Markers; Biomedical Research; Biometry; Biotechnology; Businesses; California; Center for Translational Science Activities; Clinical; Clinical Investigator; Clinical Research; Clinical Research Curriculum Award; Clinical Sciences; Clinical Trials; Collaborations; Communication; Communities; Community Health Services; Community Healthcare; Community Outreach; Community Physician; Computer software; Computerized Medical Record; Conceptions; Confidentiality; Data; Data Analyses; Databases; Development; Discipline; Discipline of Nursing; Doctor of Philosophy; Education; Education and Outreach; Electronics; Engineering; Ensure; Environment; Evaluation; Faculty; Fostering; Funding; General Population; Goals; Grant; Health; Health Insurance Portability and Accountability Act; Health Personnel; Health Sciences; Health system; Healthcare; Home environment; Hospitals; Human; Human Resources; Human Subject Research; Hypersensitivity; Image; Imaging technology; Immunology; Industry; Informatics; Information Technology; Institutes; Institution; Institutional Review Boards; Intellectual Property; Intervention; Link; Location; Medical center; Medicine; Mentored Clinical Scientist Development Program; Mentors; Methods; Minority-Serving Institution; Mission; Modeling; Monitor; Patient Care; Patients; Pediatric Hospitals; Performance; Pharmacologic Substance; Pharmacy facility; Phenotype; Physicians; Pilot Projects; Positioning Attribute; Postdoctoral Fellow; Public Health Nurses; Public Health Nursing; Reagent; Recruitment Activity; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Training; Resource Sharing; Resources; Rewards; Role; Safety; Sampling; Schools; Science; Scientist; Services; Site; Staging; Structure; Students; System; Technology; Telecommunications; Testing; Therapeutic Agents; Time; Tissue Sample; Training; Training Support; Translating; Translational Research; Translations; Universities; University Hospitals; Vision; base; biomedical informatics; career; data management; design; empowered; evidence base; experience; forging; high school; improved; innovation; institutional financing; material transfer agreement; medical schools; medical specialties; multidisciplinary; new technology; next generation; novel; novel strategies; novel therapeutics; outreach program; pre-doctoral; programs; protocol development; repository; square foot; supercomputer; tool; translational medicine

We have established the San Diego Clinical and Translational Research Institute (San Diego CTRI), with its hub located at the University of California, San Diego (UCSD). This regional center contains two universities (UCSD and San Diego State University), 4 biomedical research institutes (Salk Inst., Burnham Inst., J. Craig Venter Inst., and La Jolla Inst, for Allergy and Immunology), and 3 academic hospitals (UCSD Medical Center, VA Hospital and Rady Children's Hospital), one community health service (Palomar Pomerado Health) and 2 specialized resources--the San Diego Supercomputer Center and the California Inst, for Telecommunications and Information Technology. The CTSA program encompasses 3 health sciences professional schools (Medicine, Pharmacy, Nursing), nine clinical research PhD programs, and a Masters program in Advanced Clinical Studies. The program goals are to: 1) Provide an academic home for the discipline of clinical and translational science; 2) Establish an integrated educational pipeline to train and support clinical and translational scientists; 3) Develop a robust clinical research infrastructure that replaces silos with integrated research; 4) Enhance bioinformatics capabilities that leverage unique UCSD resources; 5) Develop novel technologies to improve research such as biomarker and imaging; 6) Form a Translational Research Alliance with research institutes and industry; 7) Form a Community Alliance with community physicians and the general public to translate scientific discoveries into best practices, increase research into health care disparities, and involve the general public in biomedical science. The CTSA program will provide the resources to develop the discipline of clinical and translational research. Through the San Diego CTRI, the educational pipeline to train the next generation of clinical and translational scientists will be enhanced. A new K12 program, an expanded K30 program, and the integration of new PhD graduate programs in clinical research highlight the proposed educational plan. The CTRI will transform education in clinical and translational science by coordinating disparate programs, providing breadth of education from high school through pre-doctoral students and providing training to post-doctoral fellows and faculty. The Institute will also transform the conduct of clinical research by providing guidance and support from initial planning through data analysis and sharing. The new structure will foster development of novel technologies to facilitate clinical research and provide support for the services and resources necessary to conduct clinical investigation. We will place special emphasis on several areas of strength such as imaging, biomarkers, community outreach, and the translation of basic science discoveries to clinical science.

我们建立了圣地亚哥临床和转化研究所（圣地亚哥 CTRI），其中心位于加州大学圣地亚哥分校（UCSD）。该区域中心包含两所大学（加州大学圣地亚哥分校和圣地亚哥州立大学）、4 个生物医学研究所（索尔克研究所、伯纳姆研究所、J. 克雷格文特尔研究所和拉霍亚过敏和免疫学研究所）以及 3 所学术医院（加州大学圣地亚哥分校医疗中心、退伍军人管理局医院和拉迪儿童医院）、一项社区卫生服务机构（Palomar Pomerado Health）和 2 个专业资源——圣地亚哥超级计算机中心和加州研究所，电信和信息技术。 CTSA 项目包括 3 个健康科学专业学院（医学、药学、护理）、9 个临床研究博士项目和一个高级临床研究硕士项目。该项目的目标是： 1）为临床和转化科学学科提供学术家园； 2）建立综合教育渠道来培训和支持临床和转化科学家； 3) 开发强大的临床研究基础设施，用综合研究取代孤岛； 4）利用加州大学圣地亚哥分校独特的资源，增强生物信息学能力； 5）开发新技术以改进生物标志物和成像等研究； 6）与研究机构和产业界组建转化研究联盟； 7) 与社区医生和公众组成社区联盟，将科学发现转化为最佳实践，加强对医疗保健差异的研究，并让公众参与生物医学科学。 CTSA 计划将为临床和转化研究学科的发展提供资源。通过圣地亚哥 CTRI，培训下一代临床和转化科学家的教育渠道将得到加强。新的 K12 项目、扩展的 K30 项目以及临床研究中新的博士研究生项目的整合突出了拟议的教育计划。 CTRI 将通过协调不同的项目、提供从高中到博士前学生的广泛教育以及为博士后研究员和教师提供培训来改变临床和转化科学的教育。该研究所还将通过提供从最初规划到数据分析和共享的指导和支持来改变临床研究的进行。新结构将促进新技术的开发，以促进临床研究，并为进行临床研究所需的服务和资源提供支持。我们将特别强调成像、生物标志物、社区外展以及基础科学发现到临床科学的转化等几个优势领域。

项目成果

Editors' overview: Neuroethics: many voices and many stories.

编辑概述：神经伦理学：许多声音和许多故事。

• DOI: 10.1007/s11948-012-9398-z
• 发表时间: 2012
• 期刊: Science and engineering ethics
• 影响因子: 3.7
• 作者: Kalichman,Michael;Plemmons,Dena;Bird,StephanieJ
• 通讯作者: Bird,StephanieJ

ESCRO committees--not dead yet.

ESCRO 委员会——尚未消亡。

• DOI: 10.1080/15265161.2013.747311
• 发表时间: 2013
• 期刊: The American journal of bioethics : AJOB
• 作者: Devereaux,Mary;Kalichman,Michael
• 通讯作者: Kalichman,Michael

Binding of Anticell Adhesive Oxime-Crosslinked PEG Hydrogels to Cardiac Tissues.

• DOI: 10.1002/adhm.201500167
• 发表时间: 2015-06-24
• 期刊: Advanced healthcare materials
• 影响因子: 10
• 作者: Grover GN;Garcia J;Nguyen MM;Zanotelli M;Madani MM;Christman KL
• 通讯作者: Christman KL

A randomized, triple-masked, active-controlled investigation of the relative effects of dose, concentration, and infusion rate for continuous popliteal-sciatic nerve blocks in volunteers.

一项随机、三重屏蔽、主动对照研究，研究剂量、浓度和输注速率对志愿者连续腘坐骨神经阻滞的相对影响。

• DOI: 10.1093/bja/aeu333
• 发表时间: 2015
• 期刊: British journal of anaesthesia
• 影响因子: 9.8
• 作者: Madison,SJ;Monahan,AM;Agarwal,RR;Furnish,TJ;Mascha,EJ;Xu,Z;Donohue,MC;Morgan,AC;Ilfeld,BM
• 通讯作者: Ilfeld,BM

Effect of the Family-Centered Advance Care Planning for Teens with Cancer Intervention on Sustainability of Congruence About End-of-Life Treatment Preferences: A Randomized Clinical Trial.

• DOI: 10.1001/jamanetworkopen.2022.20696
• 发表时间: 2022-07-01
• 期刊: JAMA NETWORK OPEN
• 影响因子: 13.8
• 作者: Needle, Jennifer Susan;Friebert, Sarah;Thompkins, Jessica D.;Grossoehme, Daniel H.;Baker, Justin N.;Jiang, JiJi;Wang, Jichuan;Lyon, Maureen E.
• 通讯作者: Lyon, Maureen E.