Genomic screening to identify novel stress-inducing chemotherapies for carcinoma

基因组筛选以确定新型应激诱导癌症化疗药物

• 批准号: 8182154
• 负责人: Andrew Michael Fribley
• 金额: $ 24.9万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8182154
• 关键词: Academia; Address; Adjuvant Therapy; Affect; Apoptosis; Apoptotic; Biological Assay; Breathing; Carcinoma; Caring; Cell Death; Cell Line; Cells; Chemicals; Cisplatin; Development; Disease; Dose; Drug Interactions; Drug Kinetics; Enzymes; Funding; Genetic Programming; Genomics; Glean; Growth; Head and Neck Neoplasms; Head and Neck Squamous Cell Carcinoma; Head and neck structure; Human; In Vitro; Individual; Instruction; Investigation; Laboratories; Lead; Libraries; Luciferases; Malignant Epithelial Cell; Mediating; Metabolic; Metabolism; Michigan; Molecular Target; Neoplasm Metastasis; Operative Surgical Procedures; P-Glycoprotein; Pain; Pathway interactions; Patients; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Physiological; Probability; Proteasome Inhibition; Proteins; Pump; Radiation; Radiation therapy; Reporter; Reporting; Resistance; Screening procedure; Sensitivity and Specificity; Series; Signal Transduction; Stress; Structure; Structure of thyroid parafollicular cell; Survival Rate; Technology; Testing; Tumor Burden; Universities; Work; Xenograft Model; Xenograft procedure; analog; arm; base; cellular targeting; chemotherapy; cost effective; cytotoxic; drug clearance; drug development; drug metabolism; high throughput screening; improved; in vivo; insight; killings; mouth squamous cell carcinoma; neoplastic cell; new therapeutic target; novel; protein folding; research study; response; small molecule; small molecule libraries; success; therapeutic development; treatment strategy; tumor