Regulation of p120-catenin tumor supressor activities

p120-连环蛋白肿瘤抑制活性的调节

• 批准号: 8270098
• 负责人: DOUGLAS B STAIRS
• 金额: $ 24.15万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8270098
• 关键词: Ablation; Adherens Junction; Binding; Biological; Biological Models; CDKN2A gene; Cancer Biology; Cell Culture Techniques; Cell Line; Cells; Cyclin D1; Cytoplasm; Development; Diagnosis; Disease; E-Cadherin; Epidermal Growth Factor Receptor; Epithelial Cells; Esophageal; Esophageal Adenocarcinoma; Esophageal Neoplasms; Esophageal Squamous Cell; Esophagus; Frequencies; Genes; Genetic; Genetically Engineered Mouse; Histocompatibility Testing; Human; Immune; In Vitro; Inflammation; Intestines; Lead; Limited Stage; Malignant Neoplasms; Malignant Squamous Cell Neoplasm; Malignant neoplasm of esophagus; Mentors; Metaplastic; Metastatic Lesion; Modality; Molecular; Mutation; Neoplasm Metastasis; Oncogenes; Pathogenesis; Pathway interactions; Phenotype; Proteins; Regulation; Research; Role; Squamous Epithelium; Staging; Survival Rate; Therapeutic Intervention; Tissues; Translating; Tumor Suppressor Genes; United States; base; beta catenin; catenin p120ctn protein; cell motility; combinatorial; in vivo; insight; keratinocyte; male; metaplastic cell transformation; mouse model; novel; novel diagnostics; novel therapeutics; outcome forecast; overexpression; rho; therapeutic target; transdifferentiation; tumor; tumor initiation; tumor progression; tumorigenesis