Mass Spectroscopy Core

质谱核心

• 批准号: 8461058
• 负责人: Mikhail Y Golovko
• 金额: $ 20.55万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8461058
• 关键词: Adenosine; Award; Biomedical Research; Centers of Research Excellence; Cholesterol; Collaborations; Comb animal structure; Connecticut; Core Facility; Country; DNA Modification Process; Data Analyses; Data Collection; Databases; Development; Ensure; Extramural Activities; Faculty; Fatty Acids; Funding; Geographic Locations; Goals; Grant; Health; Health Sciences; Hospitals; Human; Human Resources; Hydroxycholesterols; Isoprostanes; Kentucky; Laboratories; Lipid Peroxidation; Lipoxygenase; Lysophospholipids; Manuscripts; Mass Spectrum Analysis; Medical center; Methods; Montana; Neurodegenerative Disorders; Nutritional Study; Paper; Peer Review; Phase; Policies; Positioning Attribute; Preparation; Prostaglandins; Proteomics; Publications; Quality Control; Relative (related person); Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Sampling; Scientist; Services; Structure; Students; Training; United States National Institutes of Health; Universities; Visit; Work; base; conflict resolution; cost; drug metabolism; graduate student; instrument; investigator training; lysophosphatidic acid; medical schools; meetings; metabolomics; operation; programs; small molecule; statistics; web site

The Mass Spectrometry Core Facility provides support to enable traditional and non-traditional users of mass spectrometry the ability to apply advanced mass spectrometry analysis of small molecules to achieve their research objectives. The major focus of this Core is small molecule analysis including metabolomics, lipidomics, drug metabolism, molecule structure identification, and small molecule quantification. According to the Network of IDeA Funded Core Laboratories database, out of 63 mass spectrometry core facilities listed, only seven (7) provide small molecule analysis service, and just four (4) allow for lipidomic analysis. The relative uniqueness of our small molecule mass spectrometry analysis of small molecules has resulted in a recent surge in demand for our services, a dramatic increase in the publication of manuscripts, and an increase in submission and receipt of funded grants. The major roles of this Mass Spectrometry Core Facility are to: (1) Provide a facility for the use of established methods of mass spectroscopic analysis of small molecules; (2) Actively develop new mass spectrometry approaches for small molecule analysis, as well as data collection and analysis; (3) Continuously expand our capacity and capabilities to support new research projects; (4) Provide advanced training in mass spectrometry especially to graduate students; (5) Assist with new faculty hiring; and (6) Aid off-campus investigators with similar analyses. The operation of this Core is based on approved policies posted on the Core's website that regulate services provided, access to the instruments, training, quality control, cost, and conflict resolution. Currently, we are providing two major types of services: (1.) Full service where Core personnel perform the analyses and train investigators for sample extraction and preparation; and (2.) Self service where Core personnel train investigators to perform their own sample extraction, preparation and analysis. Our advisory board provides input on these policies and activities. COBRE Phase III support of the Mass Spectrometry Core Facility will enable us to support existing and future research projects, will enhance our sustainability, and will significantly facilitate the development of biomedical research in the Central Region and beyond.

质谱核心设施提供支持，使传统和非传统质谱用户能够应用先进的小分子质谱分析来实现其研究目标。该核心的主要重点是小分子分析，包括代谢组学、脂质组学、药物代谢、分子结构鉴定和小分子定量。根据 IDeA 资助的核心实验室网络数据库，在列出的 63 个质谱核心设施中，只有七 (7) 个提供小分子分析服务，只有四 (4) 个允许进行脂质组学分析。我们对小分子的小分子质谱分析的相对独特性导致最近对我们服务的需求激增，手稿出版量急剧增加，以及资助赠款的提交和收到的增加。该质谱核心设施的主要作用是： (1) 为使用已建立的小分子质谱分析方法提供设施； （2）积极开发新的小分子分析质谱方法以及数据收集和分析； （3）不断扩大我们支持新研究项目的能力和能力； （4）特别针对研究生提供质谱方面的高级培训； （5）协助新教师的聘用； (6) 帮助校外调查人员进行类似的分析。该核心的运作基于核心网站上发布的批准政策，这些政策规范所提供的服务、仪器的使用、培训、质量控制、成本和冲突解决。目前，我们提供两种主要类型的服务：（1）全程服务，由核心人员进行分析并培训研究人员进行样品提取和制备； (2.) 自助服务，核心人员培训调查人员进行自己的样品提取、制备和分析。我们的顾问委员会就这些政策和活动提供意见。 COBRE 对质谱核心设施的 III 期支持将使我们能够支持现有和未来的研究项目，增强我们的可持续性，并将显着促进中部地区及其他地区生物医学研究的发展。