Research Education in Statistical Genetics of Substance Abuse

药物滥用统计遗传学研究教育

• 批准号: 7590562
• 负责人: MICHAEL CHURTON NEALE
• 金额: $ 28.76万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7590562
• 关键词: Address; Alcohol or Other Drugs use; Area; Behavioral Genetics; Biometry; Clinical; Communities; Dependence; Development; Doctor of Philosophy; Drug abuse; Education; Education Projects; Educational Curriculum; Educational process of instructing; Educational workshop; Environment; Fostering; Future; Genetic; Goals; Human; Individual; Institutes; Institution; Interdisciplinary Study; Internet; Libraries; Mathematics; Mentors; Mission; Molecular Genetics; Monitor; National Institute of Drug Abuse; Participant; Pharmacology; Positioning Attribute; Psychology; Public Health; Publishing; Range; Recruitment Activity; Research; Research Personnel; Research Project Grants; Research Training; Statistical Methods; Substance abuse problem; Time; Training; Training Programs; Universities; Virginia; career; cohort; design; field study; genetic epidemiology; multidisciplinary; post-doctoral training; pre-doctoral; programs; software development; statistics

DESCRIPTION (provided by applicant): This application seeks support from the National Institute on Drug Abuse R25 mechanism for pre-doctoral and postdoctoral research positions at the Virginia Institute for Psychiatric and Behavioral Genetics (VIPBG) at Virginia Commonwealth University (VCU). The overall goal of this research education program is to provide an environment that encourages the development and application of statistical genetics at the highest levels. To accomplish this goal, a research education program in statistical genetics will been developed to foster interdisciplinary research, a key tenet of the NIDA mission, and which we believe is essential to conducting research in this field. Two areas of research focus are identified: Advanced Genetic Epidemiology and Statistical Molecular Genetics. These areas are synergistic and address a diverse variety of statistical methods, both those in current use and those under development. The research education program consists of pre-doctoral and postdoctoral components. Pre-doctoral participants will pursue degrees in either Human and Molecular Genetics or Biostatistics. This component is designed to recruit, at the earliest time in their careers, potential future investigators to research in statistical genetics focused on substance use, abuse and dependence (SUAD). The aim is to create a cohort of PhD graduates who are have been extensively exposed to, and begun to publish research in, this area at the outset of their research training. The postdoctoral component recognizes that many promising young researchers have training in areas relevant to, but not focused on, the statistical genetics of substance use and abuse. This flexible 2-3 year postdoctoral training component will help guide young investigators to this field of study and will provide them with integrated and focused training that will enable them to pursue careers in statistical genetics of SUAD. Research education is intended for individuals with training in mathematics, statistics, biostatistics, genetics, psychology or pharmacology and to those who have completed their clinical requirements for the MD degree. The goal of the postdoctoral component is to educate independent investigators who will contribute to the efforts to identify and characterize the genetic and environmental determinants of SUAD; they are expected to do so at VCU and at other institutions nationwide. To accomplish the overall program goal we will: i) Offer and carefully monitor a multidisciplinary integrated research training program with a range of research opportunities; ii) Meet the needs for training in emerging research areas in SUAD; iii) Provide training to researchers from diverse academic and ethnic backgrounds and intensive mentoring; iv) Provide a specialized curriculum that will merge strengths in SUAD research at our institution; and v) Disseminate course materials, developed software, user guides and example scripts to the wider community by teaching workshops and establishing a website with web casts, pod casts and script libraries. PUBLIC HEALTH RELEVANCE: This project seeks support from the NIDA R25 research education program in statistical genetics of substance abuse. Two pre-doctoral and three postdoctoral participants will pursue individualized courses of training in statistical genetics, and participate in active research projects in the Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University.

描述（由申请人提供）：本申请寻求国家药物滥用研究所 R25 机制的支持，为弗吉尼亚联邦大学 (VCU) 弗吉尼亚精神病学和行为遗传学研究所 (VIPBG) 的博士前和博士后研究职位提供支持。该研究教育计划的总体目标是提供一个鼓励最高水平的统计遗传学开发和应用的环境。为了实现这一目标，将制定统计遗传学研究教育计划，以促进跨学科研究，这是 NIDA 使命的关键宗旨，我们认为这对于在该领域开展研究至关重要。确定了两个研究重点领域：高级遗传流行病学和统计分子遗传学。这些领域是协同作用的，涉及多种统计方法，包括当前使用的和正在开发的统计方法。研究教育计划由博士前和博士后组成。博士前参与者将攻读人类和分子遗传学或生物统计学学位。该部分旨在在职业生涯的早期招募潜在的未来研究人员，以研究专注于药物使用、滥用和依赖（SUAD）的统计遗传学。目的是培养一批博士毕业生，他们在研究培训之初就广泛接触该领域并开始发表研究成果。博士后部分认识到许多有前途的年轻研究人员接受过与药物使用和滥用的统计遗传学相关但不重点的领域的培训。这种灵活的 2-3 年博士后培训部分将有助于引导年轻研究人员进入这一研究领域，并为他们提供综合和有针对性的培训，使他们能够从事 SUAD 统计遗传学的职业生涯。研究教育面向接受过数学、统计学、生物统计学、遗传学、心理学或药理学培训的个人，以及已完成医学博士学位临床要求的个人。博士后部分的目标是教育独立研究人员，他们将为识别和表征 SUAD 的遗传和环境决定因素做出贡献；预计他们将在弗吉尼亚联邦大学和全国其他机构这样做。为了实现总体计划目标，我们将： i) 提供并仔细监控 多学科综合研究培训计划，提供一系列研究机会； ii) 满足SUAD新兴研究领域的培训需求； iii) 为研究人员提供培训 多元化的学术和种族背景以及密集的指导； iv) 提供专业课程，融合我们机构 SUAD 研究的优势； v) 通过举办教学研讨会和建立一个包含网络广播、播客和脚本库的网站，向更广泛的社区传播课程材料、开发的软件、用户指南和示例脚本。公共健康相关性：该项目寻求药物滥用统计遗传学方面的 NIDA R25 研究教育计划的支持。两名博士前和三名博士后参与者将接受统计遗传学方面的个性化培训课程，并参与弗吉尼亚联邦大学弗吉尼亚精神病学和行为遗传学研究所的活跃研究项目。