Duke CTSA

杜克大学CTSA

• 批准号: 8467106
• 负责人: ROBERT M CALIFF
• 金额: $ 17.98万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2013-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8467106
• 关键词: Biological; Child health care; Clinical; Clinical Research; Collaborations; Communities; Continuing Education; County; Data; Disease; Effectiveness; Electronics; Elements; Evaluation; Fostering; Funding; Future; Generations; Genomics; Grant; Health; Health Services Research; Health system; Healthcare Systems; Home environment; Human; Institutes; Instruction; Investigation; Joints; Learning; Link; Measurable; Medical; Medicine; Methods; Mission; Modification; Molecular Analysis; Outcome; Output; Phase; Pilot Projects; Population; Research; Research Personnel; Research Project Grants; Resources; System; Systems Biology; Technology; Training; Training and Education; Translational Research; Translations; United States National Institutes of Health; Work; base; biomedical informatics; care delivery; career development; clinical application; comparative effectiveness; effectiveness research; experience; flexibility; global health; improved; innovation; meetings; next generation; novel; public-private partnership; skills; social; tool; translational medicine

PROJECT SUMMARY (See instructions): The mission of the Duke Translational Medicine Institute (DTMI) is to catalyze translation across the continuum from scientific discovery to clinical research to care delivery and global health. We propose to fulfill this mission by achieving four Specific Aims:1) Implement the next phase of the clinical and translational research at Duke, by enhancing its scope, its operational effectiveness, and the number of researchers it serves; 2) Provide DTMI investigators with biomedical informatics tools and methods needed to enhance the operational effectiveness of this next phase of the DTMI; 3) Train the next generation of clinical and translational research leaders and support continuing education to enhance the skills of the current generation of research leaders; 4) Develop methods and approaches for integrating research results into practice and practice outcomes into research. While we succeeded in building a home for clinical and translational researchers in the first funding cycle of the CTSA grant, recent discussions at the NIH and our own assessments have pointed out the need for further transformation of the system. Major emphasis must be placed on measurable output, project management, enterprise portfolio management, and public-private partnerships. These themes were reflected in the work of the DTMI during our first five years, and we are prepared to accelerate this effort by: implementing innovative approaches to pilot projects, creating a translational technology resource network, and supporting novel methods. A global proof of concept network to study human systems biology is a key element of DTMI. All human research projects in Duke Medicine (over 4,100) will be coordinated within the same electronic management system. Innovative elements of the plan include novel public private partnerships, a highly developed project management system, and an innovative approach to integration of medical, financial, operational, environmental, and social data into a geospatially referenced enterprise data warehouse. This powerful system, combined with tools that enable use of the data in concert with the community, has enabled the planning for a county-wide effort to improve health outcomes while enabling health services research and joint investigation of biological, medical, and social causes of health and disease. Special emphasis will be placed on integration of child health and comparative effectiveness research into DTMI, as well as on health studies that foster both community engagement and analysis of molecular and genomic data in populations. The flexible DTMI approach emphasizes constant evaluation and modifications based on a detailed continuous improvement paradigm.

项目摘要（请参阅说明）：杜克翻译医学研究所（DTMI）的使命是催化从科学发现到临床研究再到护理交付和全球健康的连续性翻译。我们建议通过实现四个具体目标来实现这一任务：1）通过提高其范围，其运营效率及其所服务的研究人员的数量来实施杜克大学的临床和转化研究的下一阶段； 2）为DTMI调查人员提供生物医学信息学工具和方法，以增强DTMI下一阶段的操作有效性； 3）培训下一代临床和转化研究领导者，并支持继续教育，以提高当前研究领导者的技能； 4）开发将研究结果整合到实践和实践结果中的方法和方法。尽管我们成功地在CTSA赠款的第一个融资周期中为临床和转化研究人员建造了房屋，但NIH的最新讨论和我们自己的评估指出，需要对系统进行进一步转换。必须重点放在可衡量的产出，项目管理，企业投资组合管理和公私合作伙伴关系上。这些主题在我们的头五年中反映在DTMI的工作中，我们准备通过以下方式加速这一努力：实施创新的试点项目，创建转化技术资源网络并支持新颖方法。研究人类系统生物学的全球概念网络证明是DTMI的关键要素。杜克大学医学的所有人类研究项目（超过4,100）将在同一电子管理系统中进行协调。该计划的创新元素包括新颖的公共私人合作伙伴关系，高度发达的项目管理系统，以及将医疗，财务，运营，环境和社会数据整合到一个地理空间引用的企业数据仓库中的创新方法。这个强大的系统，结合了能够与社区共同使用数据的工具，这使得为改善健康结果的努力提供了计划，同时促进健康服务研究以及对健康和疾病的生物学，医疗和社会原因的共同调查。特别强调儿童健康和比较有效性研究与DTMI的整合，以及促进人群中分子和基因组数据的社区参与和分析的健康研究。灵活的DTMI方法强调了基于详细的持续改进范式的持续评估和修改。